全文获取类型
收费全文 | 7283篇 |
免费 | 393篇 |
国内免费 | 45篇 |
专业分类
耳鼻咽喉 | 49篇 |
儿科学 | 117篇 |
妇产科学 | 43篇 |
基础医学 | 953篇 |
口腔科学 | 99篇 |
临床医学 | 510篇 |
内科学 | 1991篇 |
皮肤病学 | 132篇 |
神经病学 | 714篇 |
特种医学 | 286篇 |
外科学 | 1259篇 |
综合类 | 43篇 |
一般理论 | 4篇 |
预防医学 | 167篇 |
眼科学 | 84篇 |
药学 | 424篇 |
中国医学 | 23篇 |
肿瘤学 | 823篇 |
出版年
2023年 | 87篇 |
2022年 | 155篇 |
2021年 | 249篇 |
2020年 | 148篇 |
2019年 | 208篇 |
2018年 | 259篇 |
2017年 | 143篇 |
2016年 | 180篇 |
2015年 | 186篇 |
2014年 | 239篇 |
2013年 | 275篇 |
2012年 | 474篇 |
2011年 | 562篇 |
2010年 | 286篇 |
2009年 | 238篇 |
2008年 | 414篇 |
2007年 | 421篇 |
2006年 | 386篇 |
2005年 | 363篇 |
2004年 | 353篇 |
2003年 | 326篇 |
2002年 | 304篇 |
2001年 | 98篇 |
2000年 | 80篇 |
1999年 | 107篇 |
1998年 | 72篇 |
1997年 | 52篇 |
1996年 | 46篇 |
1995年 | 35篇 |
1994年 | 49篇 |
1993年 | 39篇 |
1992年 | 58篇 |
1991年 | 69篇 |
1990年 | 65篇 |
1989年 | 59篇 |
1988年 | 50篇 |
1987年 | 75篇 |
1986年 | 38篇 |
1985年 | 34篇 |
1984年 | 31篇 |
1983年 | 24篇 |
1980年 | 22篇 |
1979年 | 28篇 |
1978年 | 23篇 |
1977年 | 21篇 |
1975年 | 21篇 |
1974年 | 25篇 |
1972年 | 29篇 |
1969年 | 32篇 |
1966年 | 21篇 |
排序方式: 共有7721条查询结果,搜索用时 15 毫秒
81.
Aoi Ohira Sayaka Yamaguchi Takuya Miyagi Yu‐ichi Yamamoto Satoshi Yamada Hideo Shiohira Keisuke Hagiwara Tsukasa Uno Hiroshi Uezato Kenzo Takahashi 《The Journal of dermatology》2013,40(8):629-631
Fixed drug eruption is a common cutaneous adverse reaction in young patients with a characteristic clinical appearance. However, the diagnosis and identification of the substance may be difficult if food or food additives provoke the fixed eruption. A 26‐year‐old man had a history of two episodes of cutaneous erythema with residual pigmentation. Close examination of the history including his diet in addition to an oral challenge test and patch testing led to the diagnosis of fixed eruption secondary to quinine in tonic water. We examined for the presence of quinine in commercially available brands of tonic water using ultraviolet A and irradiation and high‐performance liquid chromatography. Both Schweppes and CANADA DRY brands of tonic water emitted fluorescent light upon ultraviolet A irradiation, and contained quinine at concentrations of 67.9 and 61.3 mg/L, respectively. Quinine contained in some tonic waters may trigger fixed eruption. 相似文献
82.
83.
Contrast‐enhanced harmonic endoscopic ultrasonography for differential diagnosis of localized gallbladder lesions 下载免费PDF全文
Ken Kamata Mamoru Takenaka Masayuki Kitano Shunsuke Omoto Takeshi Miyata Kosuke Minaga Kentaro Yamao Hajime Imai Tosiharu Sakurai Naoshi Nishida Hiroshi Kashida Takaaki Chikugo Yasutaka Chiba Takuya Nakai Yoshifumi Takeyama Andrea Lisotti Pietro Fusaroli Masatoshi Kudo 《Digestive endoscopy》2018,30(1):98-106
Background and Aim
Differential diagnosis of localized gallbladder lesions is challenging. The aim of the present study was to evaluate the utility of contrast‐enhanced harmonic endoscopic ultrasonography (CH‐EUS) for diagnosis of localized gallbladder lesions.Methods
One hundred and twenty‐five patients with localized gallbladder lesions were evaluated by CH‐EUS between March 2007 and February 2014. This was a single‐center retrospective study. Utilities of fundamental B‐mode EUS (FB‐EUS) and CH‐EUS in the differentiation of gallbladder lesions and sludge plug were initially compared. Thereafter, these two examinations were compared with respect to their accuracy in the diagnosis of malignant lesions. Five reviewers blinded to the clinicopathological results evaluated microcirculation patterns in the vascular and perfusion images.Results
In the differentiation between gallbladder lesions and sludge plug, FB‐EUS had a sensitivity, specificity, and accuracy of 82%, 100%, and 95%, respectively, whereas CH‐EUS had a sensitivity, specificity, and accuracy of 100%, 99%, and 99%, respectively. FB‐EUS‐based diagnosis of carcinomas based on tumor size and/or shape had a sensitivity, specificity, and accuracy of 61–87%, 71–88%, and 74–86%, respectively. Additional information regarding irregular vessel patterns in the vascular image and/or heterogeneous enhancement in the perfusion image on CH‐EUS increased the sensitivity, specificity, and accuracy for the diagnosis of carcinomas to 90%, 98%, and 96%, respectively. There was a significant difference between FB‐EUS and CH‐EUS in terms of carcinoma diagnosis.Conclusion
CH‐EUS was useful for the evaluation of localized gallbladder lesions. 相似文献84.
Makio Kusaoi Ken Yamaji Go Murayama Misa Yasui Risa Yamada Ruka Hishinuma Takuya Nemoto Katsura Hohtatsu Michiaki Kageyama Toshio Kawamoto Kaoru Sugimoto Fumio Sekiya Takayuki Kon Michihiro Ogasawara Kazuo Kempe Hiroshi Tsuda Yoshinari Takasaki 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2012,16(5):456-466
Leukocytapheresis (LCAP) is a safe, unique therapy pertaining to intractable rheumatoid arthritis (RA) even in cases of drug allergy or infectious states. To investigate how to represent LCAP efficacy, we have conducted gene expression analyses from the peripheral blood of RA patients treated with non‐woven polyethylene terephthalate filters. Peripheral blood samples were collected immediately before and after treatment from eight RA patients who received LCAP. Among these patients, all of them achieved 20% improvement in the core set of the American College of Rheumatology (ACR20), and thus, they were confirmed as LCAP responders. Gene expression analysis was done with a high‐resolution DNA microarray. The results of each of the two groups' gene expression values (immediately before and after LCAP) were calculated using Welch's t‐test. Calculations were performed with a statistical software R.basic package: if the P‐value was less than 0.05, this was seen as a significant change. In a comparison of 25 370 gene expressions, the number of genes showing a P‐value < 0.05 in the upregulating group was 2110, and in the downregulating group it was 1864. The results of pathway analysis using the MetaCore program indicate that gene groups work for cytoskeletal remodeling are upregulated, and genes related to immune responses, such as antigens presenting via major histocompatibility complex class I and II, are downregulated just after LCAP. These findings may relate to LCAP efficacy for RA patients, but this needs further investigation. 相似文献
85.
86.
87.
Chikako Kusunoki Takuya Hamakawa Kazuhiro Nishikawa Hiromichi Sato Sayumi Imamura Satoru Miyahara Yu Sakano Hazuki Miyazaki Hiroto Seto Ryuta Ueda Reishi Toshiyama Masaaki Miyo Yusuke Takahashi Kenji Sakai Masakazu Miyake Atsushi Miyamoto Takeshi Kato Kiyoshi Mori Motohiro Hirao 《Asian journal of endoscopic surgery》2021,14(4):794-797
Laparoscopic wedge resection (LWR) for intraluminal gastrointestinal stromal tumor (GIST) leads to excessive resection of normal gastric wall. We report a case of GIST around the cardia successfully treated with full-thickness partial resection using a hybrid approach of laparoscopic surgery and single-incision intragastric surgery (SIIGS). A 69-year-old woman had a 5 cm intraluminal GIST at the posterior wall around the cardia. Submucosal injection of glycerin and indigo carmine was performed with transoral endoscopy. Circumferential seromuscular incision followed by placement of seromuscular sutures to invert the lesion into the stomach was performed under laparoscopy. By SIIGS, resection of the inverted mucosa and retrieval of the tumor were completed. A hybrid approach consisting of laparoscopic wall-inversion surgery and SIIGS was useful for intraluminal GIST and may expand the indications for laparoscopic wall-inversion surgery by removing size limitations. 相似文献
88.
Takashi Kitagataya Goki Suda Kazunori Nagashima Takehiko Katsurada Koji Yamamoto Megumi Kimura Osamu Maehara Ren Yamada Taku Shigesawa Kazuharu Suzuki Akihisa Nakamura Masatsugu Ohara Machiko Umemura Naoki Kawagishi Masato Nakai Takuya Sho Mitsuteru Natsuizaka Kenichi Morikawa Koji Ogawa Shunsuke Ohnishi Yoshito Komatsu Hiroo Hata Satoshi Takeuchi Takashige Abe Jun Sakakibara-Konishi Takanori Teshima Akihiro Homma Naoya Sakamoto 《Journal of gastroenterology and hepatology》2020,35(10):1782-1788
89.
90.