全文获取类型
收费全文 | 257篇 |
免费 | 12篇 |
专业分类
儿科学 | 47篇 |
基础医学 | 28篇 |
口腔科学 | 1篇 |
临床医学 | 20篇 |
内科学 | 54篇 |
皮肤病学 | 9篇 |
神经病学 | 22篇 |
外科学 | 44篇 |
综合类 | 2篇 |
预防医学 | 1篇 |
眼科学 | 1篇 |
药学 | 24篇 |
中国医学 | 3篇 |
肿瘤学 | 13篇 |
出版年
2017年 | 3篇 |
2016年 | 2篇 |
2015年 | 7篇 |
2014年 | 4篇 |
2013年 | 3篇 |
2012年 | 4篇 |
2011年 | 3篇 |
2010年 | 8篇 |
2009年 | 6篇 |
2008年 | 2篇 |
2007年 | 5篇 |
2006年 | 14篇 |
2005年 | 2篇 |
2004年 | 11篇 |
2003年 | 10篇 |
2002年 | 2篇 |
2001年 | 2篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 24篇 |
1997年 | 12篇 |
1996年 | 20篇 |
1995年 | 28篇 |
1994年 | 9篇 |
1993年 | 10篇 |
1992年 | 3篇 |
1991年 | 3篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1985年 | 4篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1969年 | 1篇 |
1967年 | 2篇 |
1964年 | 4篇 |
1963年 | 1篇 |
1959年 | 1篇 |
1958年 | 1篇 |
1957年 | 3篇 |
1956年 | 7篇 |
1955年 | 7篇 |
1954年 | 9篇 |
排序方式: 共有269条查询结果,搜索用时 15 毫秒
261.
SHIGERU OKADA 《Pathology international》1996,46(5):311-332
Oxygen is poisonous, but we cannot live without It. The high oxidizing potential of oxygen molecules (dioxygen) Is a valuable source of energy for the organism and its reactivity is low; that is, spin forbidden. However, the dioxygen itself is a 'free radical' and, especially in the presence of transition metals, K is a major promoter of radical reactions in the cell. Humans survive only by virtue of their elaborate defense mechanisms against oxygen toxicity.
Iron is the most abundant transition metal in the human body- Because iron shows wide variation in redox potential with different co-ordination ligands, it may be used as a redox intermediate in many biological mechanisms. However, it is precisely this redox activeness that makes iron a key participant in free radical production.
The current research on the relationship between iron and cancer is briefly reviewed. Research results are reported here which indicate that iron, when bound to certain ligands, can cause free-radical mediated tissue damage and become carcinogenic. The present study also suggests that iron may also have a significant role in spontaneous human cancer. 相似文献
Iron is the most abundant transition metal in the human body- Because iron shows wide variation in redox potential with different co-ordination ligands, it may be used as a redox intermediate in many biological mechanisms. However, it is precisely this redox activeness that makes iron a key participant in free radical production.
The current research on the relationship between iron and cancer is briefly reviewed. Research results are reported here which indicate that iron, when bound to certain ligands, can cause free-radical mediated tissue damage and become carcinogenic. The present study also suggests that iron may also have a significant role in spontaneous human cancer. 相似文献
262.
HATAE YOSHIO; TAKEDA TAKEO; HATTORI TAKUYA; NAKADATE HISAYA; NISHI MOTOI 《Japanese journal of clinical oncology》1985,15(3):483-488
We have experienced 30 patients with neuroblastoma since 1975.Disseminated intravascular coagulation (DIC) developed in sixof these patients. They were all in stage IV, namely disseminatedneuroblastoma. These six cases with DIC proved that some advancedneuroblastomas have the potential to cause coagulopathy in theprocess of the disease. The plasma concentration of heparin was measured in some patientswho were treated with heparin. The data revealed that the conventionallyused intravenous heparin dose is not appropriate in the caseof DIC. Effective treatment requires monitoring of the plasmaconcentration of heparin. 相似文献
263.
MASAHIRO HIRAOKA IWAO FUJIMOTO CHIKAHIDE HORI HIROKAZU TSUKAHARA HIRONOBU AKINO KENICHIRO OKADA MASAKATSU SUDO 《Pediatrics international》1996,38(4):374-376
Reflux nephropathy is known to be a major cause of renal failure in children. Vesico-ureteral reflux is usually diagnosed by voiding cysto-urethrography (VCG). However, it has been observed that conventional VCG is not always reliable for the diagnosis of ureteral reflux. In the case of a 5 year old girl with recurrent febrile urinary tract infection, VCG showed no ureteral reflux. Urodynamic study revealed a large bladder capacity and significant residual urine. Renal scintigram delineated a right renal scar. Simple ultrasound examination with videotape recording during voiding definitely demonstrated the presence of significant ureteral reflux when she voided, that is, there was marked dilatation of the right distal ureter and ballooning of the right renal pelvis on voiding, and quick refilling of the bladder concomitantly with the disappearance of the pelvic ballooning. Therefore, an ultrasound during voiding may be useful for diagnosing ureteral reflux in patients where a VCG does not reveal reflux. 相似文献
264.
TOMOO OKADA YOSHIYUKI SATO TAKAHIRO YAMAZAKI FUJIHIKO IWATA MITSUHIKO HARA HIDEAKI KIM KENSUKE KARASAWA MAMORU AYUSAWA TATSUO FUCHIGAMI KENNSUKE HARADA MASAHIKO OKUNI SHIGEO RYO 《Pediatrics international》1995,37(5):582-587
The aim of this study was to evaluate the relationship between the serum levels of lipoprotein (a) [Lp (a)] and apolipoproteins (apo A-1 and apo B) in schoolchildren with a history of coronary and cerebrovascular events in their grandparents. We measured serum concentrations of Lp (a) and apoliproteins immunochemically in 289 schoolchildren aged 12–13 years and questioned parents about coronary and cerebrovascular events in the children's grandparents. In boys and girls, mean ± s.d. levels of apo A-1, apo B and Lp (a) were 134 ± 20.3 and 136 ± 17.4 mg/dL, 61 ± 16 and 66 ± 15 mg/dL and 12.5 ± 15.3 and 12.5 ± 15.1 mg/dL, respectively. There were no significant sex differences in the levels of apo A-1, apo B, and Lp (a). The Lp (a) levels (mean ± s.d., 12.5 ± 15.2 mg/dL; median 7.5 mg/dL, n = 289) were not affected by other variables. The Lp (a) distribution was strongly positively skewed and 75% of schoolchildren had very low levels. In the total 289 schoolchildren, thirty-two grandparents who had had coronary vascular events (21 myocardial infarction, 11 angina pectoris) and twenty-three grandparents who had had cerebrovascular events were recorded. By the boxplot statistical analysis, no difference was found in Lp (a) levels in children whose grandparents had myocardial infarction compared with those whose grandparents had no such history, or compared with those whose grandparents had suffered cerebrovascular events. Analysis also showed that the values of log Lp (a) in children whose grandparents had myocardial infarction tended to be higher than the values in children whose grandparents had no such history (P = 0.09). No significant differences in the levels of apo A-1 and apo B and in the apo B/A-1 ratio could be seen between children grouped according to the presence or absence of coronary and cerebrovascular events in their grandparents. These results suggest that high levels of Lp (a) in schoolchildren aged 12–13 years may partly reflect the existence of coronary vascular disease in older family members. Lp (a) may account for the strongest index of family history to disease risk in comparison with other apolipoproteins. Further study is needed to clarify the appropriate mass measurement method for Lp (a) in schoolchildren. 相似文献
265.
MITSURU OKADA KEISUKE SUGIMOTO KAZURO YAGI HIDEHIKO YANAGIDA NOBUTADA TABATA TSUKASA TAKEMURA 《Pediatrics international》2007,49(6):933-937
BACKGROUND: Cyclosporin A (CyA) can suppress relapses and reduce proteinuria in frequent-relapse nephrotic syndrome (FRNS) and steroid-resistant nephrotic syndrome (SRNS). However, some patients remain resistant to CyA therapy. The purpose of the present paper was to evaluate mycophenolate mofetil (MMF) treatment in pediatric patients with CyA-resistant intractable nephrotic syndrome. METHODS: MMF therapy was given to 11 patients with FRNS who had relapse despite CyA therapy, and one patient with SRNS who had been receiving combined therapy using steroid and CyA until immediately before the start of MMF. MMF was administered at a daily dose of 750-1000 mg/m(2) in two divided doses. RESULTS: Ten of the 11 patients with FRNS were able to maintain remission. Among them, seven patients remained relapse free for 1 year, and two patients had a decrease in the frequency of relapse after initiation of MMF therapy. One patient, however, had repeated cycles of remission and relapse, and was considered resistant to MMF therapy. The total prednisolone dose during the period from month 6 to month 12 after the start of MMF therapy was significantly lower than that during the 6 month period before the start of MMF therapy. The patient with SRNS, who had not achieved remission despite CyA administration, had complete remission on MMF. No serious adverse effects were seen in any of the present patients. CONCLUSION: MMF could be useful in CyA-treatment-refractory FRNS and CyA-resistant SRNS. 相似文献
266.
AHMED KARIM TALIB M.D. Ph.D. NOBUYUKI SATO M.D. Ph.D. AKIRA ASANOME M.D. TAKUYA MYOJO M.D. TAKESHI NISHIURA M.D. MASARU YAMAKI M.D. NAOKI NAKAGAWA M.D. Ph.D. NAKA SAKAMOTO M.D. HISANOBU OTA M.D. YASUKO TANABE M.D. Ph.D. TOSHIHARU TAKEUCHI M.D. YUICHIRO KAWAMURA M.D. Ph.D. NAOYUKI HASEBE M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2013,24(5):556-561
267.
FUMIHIRO ASANO MOTOI AOE YOSHINOBU OHSAKI YOSHINORI OKADA SHINJI SASADA SHIGEKI SATO EIICHI SUZUKI HIROSHI SENBA SHOZO FUJINO KAZUMITSU OHMORI 《Respirology (Carlton, Vic.)》2013,18(2):284-290
Background and objective: To ensure the safety of bronchoscopic practice, the Japan Society for Respiratory Endoscopy conducted a national survey to investigate the current state of procedure for this technique. Methods: A questionnaire survey about procedures carried out during the whole of the year 2010 was mailed to 538 facilities accredited by the society. Results: Responses were obtained from 511 facilities (95.0%). Rigid bronchoscopes were used in only 18.5% of the facilities, while mobile/thin bronchoscopes were used in ≥50%, and fluoroscopy systems were used in 99.8%. Biopsies were performed after discontinuation of therapy in patients receiving antiplatelet drugs and anticoagulants in 96.7% and 97.4% of the facilities, respectively. Atropine was administered for premedication in 67.5% of the facilities, a decrease from previous surveys. Intravenous sedation was given in 36.1% of the facilities. In 21.9% of these, the procedure was conducted in the outpatient clinic for ≥70% of patients. A bronchoscope was orally inserted in ≥70% of patients in 95.7% of the facilities. Intravenous access was maintained during the examination in 92.5% of the facilities, oxygen saturation was monitored during examinations in 99.0%, oxygen was administered in 97.6% and resuscitation equipment was available in 96%. In 98.6% of the facilities, bronchoscopes were disinfected using an automatic washing machine, with glutaraldehyde used in 42.2%. Conclusions: Japan‐specific characteristics of bronchoscopic practice were identified. Whether procedures used in Japan meet international guidelines with respect to safety should be monitored continuously. In addition, a Japanese evidence‐based consensus is needed. 相似文献
268.
269.
HIDEYUKI TOZAKI TOMOKAZU ODORIBA TOMOYA ISEKI TOSHIO TANIGUCHI TAKUYA FUJITA MASAHIRO MURAKAMI SHOZO MURANISHI AKIRA YAMAMOTO 《The Journal of pharmacy and pharmacology》1998,50(8):913-920
The objective of this study was to examine the effects of protease inhibitors on the absorption of calcitonin from different regions of the intestine in rats. The absorption experiments were investigated by in-situ use of closed intestinal loops in rats and stability of calcitonin was examined in mucosal homogenates and intestinal fluids. The intestinal absorption of calcitonin was evaluated by measurement of its hypocalcaemic effect. No substantial hypocalcaemic response was observed when calcitonin was administered into the jejunum or colon. A slight hypocalcaemic effect was observed after administration of calcitonin into the ileum. Of the co-administered protease inhibitors, bacitracin (20 mM) strongly promoted calcitonin absorption from the jejunum, ileum and colon. A significant hypocalcaemic effect was also obtained after intestinal administration of calcitonin with soybean trypsin inhibitor (10mgmL?1), camostat mesylate (20mM) or aprotinin (2mgmL?1). In the stability experiment, bacitracin reduced the degradation of calcitonin in the different intestinal homogenates. Soybean trypsin inhibitor significantly reduced the degradation of calcitonin in the fluids of the small intestine. We also examined the different endopeptidases in gut luminal fluids and the different exopeptidases in gut mucosal homogenates of rats. The ranking order for the total endopeptidase activity of the intestinal fluids was jejunum > ileum > colon. That for total exopeptidase activity of the intestinal mucosa was jejunum > ileum > colon. These results suggest that endo- and exopeptidases might be responsible for the hydrolysis of calcitonin and that protease inhibitors might usefully improve absorption of calcitonin to the systemic circulation from the large intestine. 相似文献