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11.
TAKUYA MYOJO M.D. NOBUYUKI SATO M.D. Ph.D. MOTOKI MATSUKI M.D. OSAMU TANIGUCHI M.D. HIDEKI NAKAMURA M.D. Ph.D. NAOYUKI HASEBE M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2012,35(1):e27-e30
We describe a case of a myocardial infarction, in which prominent ischemic J waves were documented during recurrent ventricular fibrillation attacks. The patient was referred to our hospital to treat an out‐of hospital cardiac arrest. Although the 12‐lead electrocardiogram obtained just after the first cardioversion did not show any apparent J waves, a J wave‐like steep downsloping type ST‐segment elevation associated with q waves in the inferior leads was documented during multiple episodes of ventricular fibrillation. Our report revealed the appearance of J waves as an important marker for lethal arrhythmias in acute ischemia. (PACE 2012; 35:e27–e30) 相似文献
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TADAO HASEGAWA AKIRA OKAMOTO TAKUYA KAMIMURA ICHIRO TATSUNO SHIN‐NOSUKE HASHIKAWA MITSUTAKA YABUTANI MASAKADO MATSUMOTO KEIKO YAMADA MASANORI ISAKA MASAAKI MINAMI MICHIO OHTA 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2010,118(3):167-178
Hasegawa T, Okamoto A, Kamimura T, Tatsuno I, Hashikawa S‐N, Yabutani M, Matsumoto M, Yamada K, Isaka M, Minami M, Ohta M. Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients. APMIS 2010; 118: 167–78. Streptococcal toxic shock syndrome (STSS) is a re‐emerging infectious disease in Japan and many other developed countries. Epidemiological studies have revealed that the M1 serotype of Streptococcus pyogenes is the most dominant causative isolate of STSS. Recent characterization of M1 isolates revealed that the mutation of covS, one of the two‐component regulatory systems, plays an important role in STSS by altering protein expression. We analyzed the M1 S. pyogenes clinical isolates before or after 1990 in Japan, using two‐dimensional gel electrophoresis (2‐DE) and pulsed‐field gel electrophoresis (PFGE). PFGE profiles were different between the isolates before and after 1990. Markedly different profiles among isolates after 1990 from STSS and pharyngitis patients were detected. Sequence analysis of two‐component regulatory systems showed that covS mutations were detected not only in STSS but also in three pharyngitis isolates, in which proteins from the culture supernatant displayed the invasive type. The mutated CovS detected in the pharyngitis isolates had impaired function on the production of streptococcal pyrogenic exotoxin B (SpeB) analyzed by 2‐DE. These results suggest that several covS mutations that lead to the malfunction of the CovS protein occurred even in pharyngeal infection. 相似文献
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AKIRA MATSUI YOICHI ARAKAWA TAKAYUKI MOMOYA NOBUHIKO SASAKI SEIJI KAWASAKI KOICHI TANAKA 《Pediatrics international》1996,38(6):699-701
Two infants with biliary atresia who exhibited three-fold increased trough levels of tacrolimus and required reduced doses during episodes of acute infantile diarrhea within 5 months of liver transplantation are described. The cause of the increase was not explained simply by hemoconcentration as a result of significant loss of extracellular fluid during these episodes. It does highlight an important issue: that of the continuing need to carefully monitor the trough levels of tacrolimus in such infants. 相似文献
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Herpes simplex on the nipples of a 31-year-old woman inoculated from herpetic gingivostomatitis of her baby is described. It is proposed that this condition is another special form of cutaneous inoculation herpes simplex. 相似文献
15.
Atsushi OTSUKA Hideya KAWASAKI Rikiya MATSUMOTO Hitoshi SHINBO Yutaka KURITA Toshihide IWASHITA Seiichiro OZONO 《Lower urinary tract symptoms.》2013,5(3):173-180
Objective: We examined whether interstitial cells (ICs) of the human urinary bladder expressed β‐adrenoceptor (AR) subtypes, and semiquantitatively compared the staining intensity among urothelium, ICs and detrusor muscles. Methods: Paraffin sections of the human urinary bladder were obtained from histologically normal areas of formalin‐fixed specimens removed for bladder carcinoma. Double‐labeling immunohistochemical methods using antibodies against each β‐AR subtype and vimentin were performed to identify ICs of the human urinary bladder. The staining intensity of β‐ARs was semiquantitatively compared among urothelium, ICs and detrusor muscles. Further, gender‐related difference or age‐related correlation in the staining intensity of β‐ARs was compared in the same cell types. Results: The expression of β1‐, β2‐, and β3‐AR was observed in vimentin‐positive ICs localized in suburothelium, between detrusor muscle bundles, and within these bundles of the human urinary bladder. The rank order of the staining intensity was urothelium > ICs = detrusor muscles in β1‐AR, urothelium > ICs > detrusor muscles in β2‐AR, whereas its order was ICs = detrusor muscles > urothelium in β3‐AR. Except for urothelial β1‐AR, there was no gender‐related difference in the signal intensity of β‐ARs in the urothelium, ICs or detrusor muscles. Age negatively correlated with the signal intensity of all β‐AR subtypes. Conclusion: β‐ARs were expressed in vimentin‐positive ICs of the human urinary bladder. As for β2‐ and β3‐AR, there was no gender‐related difference or age‐related correlation in urothelium, ICs and detrusor muscles. In the human urinary bladder, β‐ARs expressed in ICs may play a role in bladder physiology. 相似文献
16.
TAKUYA WATANABE MD AKIRA MIKAMI MD MASAMICHI MOTONISHI MD HIDEHARU HONDA MD KYOKO KYOTANI MD SHIGEHIKO URUHA MD KIYOJI TERASHIMA MD YOSHIO TESHIMA MD YOSHIRO SUGITA MD 《Psychiatry and clinical neurosciences》1998,52(2):231-232
Abstract Two cases of sleep disordered-breathing in climacteric were reported. Polysomnography including esophageal pressure (Pes) measurement was performed. Case 1 was diagnosed as upper airway resistance syndrome. Case 2 was diagnosed as obstructive sleep apnea syndrome, while many episodes of upper airway resistance also existed. Hormone replacement therapy improved clinical symptoms, and in case 1, Pes nadir was improved but incidence of arousals which was induced by breathing disturbances was not significantly changed. Sleep disordered-breathing should be suspected as a cause of sleep disorder even in females, especially in climacteric age. Pes measurement and evaluation of arousals is required. Hormone replacement therapy may release the upper airway resistance. 相似文献
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18.
HIRONAKA KAWASAKI M.D. SEIGO SAKAGUCHI M.D. †TOSHITAKE IRISA M.D. † CHISATO HIRAYAMA M.D. ‡ 《The American journal of gastroenterology》1978,69(4):436-442
Seventy-one patients with liver cancer were examined by B-scan ultrasonography. The presence of liver cancer was assumed through the irregularity and increased intensity of echos. The accuracy of ultrasonography in the diagnosis of liver cancer was 72%, while the diagnostic accuracy of scintigraphy was 85% and angiography 93%. No obvious correlation could be demonstrated between the ultrasonographic patterns and serum alpha-fetoprotein (AFP) levels. Ultrasonography is a useful method of detecting liver cancer. 相似文献
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