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181.
MASAO TAKATA KATSUYUKI MIYASAKA HIROKAZU SAKAI HIROYUKI FUJIWARA YUSHI ITO TOSHIO KAWANO 《Pediatrics international》1995,37(2):171-173
Persistent pulmonary hypertension of the newborn (PPHN) may occasionally require an invasive treatment with extracorporeal membrane oxygenation (ECMO). Inhaled nitric oxide (NO) has recently been introduced as a selective pulmonary vasodilator for treatment of PPHN. We describe a case of PPHN in which neither inhaled NO nor ECMO was effective in reversing pulmonary hypertension. The clinical course of the patient suggested a potential role of NO inhalation in predicting the outcome of ECMO treatment for PPHN. 相似文献
182.
TAKAYOSHI FUKUTOMI MARIE FUKUSHIMA YUICHI TANABE KAICHIRO HIROSHIGE HIDETOSHI ITASAKA TAKASHI MATSUMATA NORIKO KASAI KISAKU YOSHIDA JUNJI SUZUMIYA MASAHIRO KIKUCHI YUJI YUFU HIRONORI SAKAI JUNJI NISHIMURA HAJIME NAWATA 《Journal of gastroenterology and hepatology》1996,11(8):724-727
A case of primary splenic lymphoma in a patient with chronic hepatitis C is reported. A 69-year-old man with chronic hepatitis C was admitted to Fukuoka City Hospital for evaluation of an enlarging splenic tumour. In the spleen, ultrasonographic examination revealed a hypoechoic tumour and computed tomography demonstrated a non-enhancing low density area measuring 7 cm in diameter; coeliac angiography revealed a hypovascular tumour. Gallium scintigraphy showed uptake of the radioisotope in the splenic tumour. A splenectomy was performed and the morphological and immunohistochemical findings of this tumour were compatible with those of non-Hodgin's B cell lymphoma. Recently, cases of malignant B cell lymphoma associated with hepatitis C virus infection have been reported. Lymphotropism of hepatitis C virus may play a pathological role in the development of non-Hodgkin's lymphoma. We emphasize the importance of considering lymphoma in the differential diagnosis of extrahepatic disorders during the course of chronic hepatitis C virus infections. 相似文献
183.
184.
EFFECT OF THE ACUTE ADMINISTRATION OF SODIUM BICARBONATE ON RESPIRATION IN THE PRESENCE OF HYPEROXIA
NISHINO TAKASHI; HATA NAMIYO; SAKAKIBARA YOSHIKAZU; HONDA YOSHIYUKI 《British journal of anaesthesia》1977,49(4):331-339
The effects, on respiration, of the acute administration ofsodium bicarbonate were studied in 10 normal subjects.Carbondioxide response curves and tidal volume v. PCO2 relationshipswere obtained under hyperoxic conditions using a closed-circuitbreathing system.During alkalosis, a decrease in the slope,and a displacement of the response curves to the right, wereobserved.These findings indicate that metabolic alkalosis, inducedacutely by the administration of sodium bi-carbonate, altersthe respiratory response to carbon dioxide and that sodium bicarbonatemay have a depressant effect on respiration. 相似文献
185.
YOSHIHIRO YAMASHINA M.D. TETSUO YAGI M.D. Ph.D. AKIO NAMEKAWA M.D. AKIHIKO ISHIDA M.D. HIROKAZU SATO M.D. TAKASHI NAKAGAWA M.D. MANJIROU SAKURAMOTO M.D. EIJI SATO M.D. TOMOYUKI YAMBE M.D. Ph.D. 《Pacing and clinical electrophysiology : PACE》2012,35(12):e349-e352
A 58‐year‐old man was referred to our emergency room with hemodynamically unstable sustained ventricular tachycardia (VT). The morphology of the VT exhibited a left bundle branch block and inferior axis deviation. He had no past history of cardiovascular disease. Echocardiography, cardiac catheterization, cardiac biopsy, gallium scintigram, myocardial scintigram, T1,T2‐weighted magnetic resonance imaging (MRI), and gadolinium‐enhanced cine MRI did not detect any structural heart disease or abnormal cardiac function. However, delayed‐enhancement MRI (DE‐MRI) detected a focal intramural scar within the septal ventricular outflow tract. An electrophysiological study revealed a sustained VT with several morphologies and the entrainment phenomenon. Radiofrequency catheter ablation to the site corresponding to the focal scar detected by DE‐MRI successfully eliminated the VT. (PACE 2012;35:e349–e352) 相似文献
186.
Risk Stratification for Ventricular Tachyarrhythmias by Ambulatory Electrocardiogram‐Based Frequency Domain T‐Wave Alternans 下载免费PDF全文
MASATO KAWASAKI M.D. TAKAHISA YAMADA M.D. TAKASHI MORITA M.D. YOSHIO FURUKAWA M.D. SHUNSUKE TAMAKI M.D. YUSUKE IWASAKI M.D. ATSUSHI KIKUCHI M.D. TAKUMI KONDO M.D. SATOSHI TAKAHASHI M.D. TSUTOMU KAWAI M.D. YUJI OKUYAMA M.D. YASUSHI SAKATA M.D. MASATAKE FUKUNAMI M.D. 《Pacing and clinical electrophysiology : PACE》2015,38(12):1425-1433
187.
SHINYA TANAKA KENTARO KAMIYA NOBUAKI HAMAZAKI RYOTA MATSUZAWA KOHEI NOZAKI EMI MAEKAWA CHIHARU NODA MINAKO YAMAOKA-TOJO ATSUHIKO MATSUNAGA TAKASHI MASUDA JUNYA AKO 《Journal of cardiac failure》2018,24(11):723-732
Background
The impact of frailty on long-term prognosis in patients with heart failure (HF) remains unclear, and there is no simple and objective assessment for it. This study was performed to examine the association between frailty score and clinical outcome in elderly patients hospitalized for HF.Methods and Results
A retrospective cohort study was performed with 603 elderly patients with HF (mean age 75 ± 6 years, 378 [62.7%] men). Frailty was measured by a composite of 4 markers combined into a frailty score (possible range 0–12): gait speed, handgrip strength, serum albumin, and activities of daily living status. The patient population was divided into 2 groups with frailty score <5 (non-frail) or ≥5 (frail). The end point was all-cause mortality. Over a mean follow-up period of 1.7 ± 0.5 years, 89 patients died. After adjustment for several preexisting factors associated with prognosis, the frailty score (hazard ratio [HR] 1.11; P?=?.014) and frailty (HR 1.75; P?=?.036) were independently associated with all-cause mortality. The inclusion of frailty score significantly increased both continuous net reclassification improvement (0.341; P?=?.002) and integrated discrimination improvement (0.016; P?=?.039) for all-cause mortality.Conclusions
A simple and objective frailty score was associated with health outcome in elderly patients hospitalized for HF. 相似文献188.
Identification of basophils by immunohistochemistry in the airways of post-mortem cases of fatal asthma 总被引:4,自引:0,他引:4
T. KOSHINO S. TESHIMA N. FUKUSHIMA T. TAKAISHI K. HIRAI Y. MIYAMOTO† Y. ARAI† Y. SANO† K. ITO Y. MORITA 《Clinical and experimental allergy》1993,23(11):919-925
There is increasing evidence for the role of basophils in the pathogenesis of bronchial asthma. To examine the presence of basophils in the airways of patients with fatal asthma by immunohistochemistry, we stained lung tissues from four post-mortem cases who had died from severe asthmatic attacks and four controls with a monoclonal antibody raised against tryptase (AA-1) and anti-IgE. Mast cells and basophils were identified in the bronchioles as AA-1- and anti-IgE-positive cells, and anti-IgE-positive cells, respectively. Airway mast cells were found beneath the basement membrane, near blood vessels in the submucosa, and adjacent to the submucosal glands, and scattered throughout the muscle bundles. There was a significant increase of mast cells in the asthma group compared with the control group (203.5+/-84.6/mm2, mean+/-s.d. vs 37.7+/-8.7/mm2, P<0.05, n=4). In contrast, basophils were observed in the airway lumen, in the bronchial epithelium and in the submucosa. The number of basophils in the bronchioles was 81.8+/-55.5/mm2 (n = 4); however, basophils were not found at all in the airways of the control group. Although eosinophils, B lymphocytes and macrophages bear low affinity IgE receptors and could react with anti-IgE, the location of these cells in the close sections did not correspond closely with basophils. The presence of basophils in lung tissues obtained from fatal asthma patients supports the view that basophils play a role in the pathogenesis of bronchial asthma. 相似文献
189.
Prediction of Optimal Atrioventricular Delay in Patients with Implanted DDD Pacemakers 总被引:12,自引:0,他引:12
TOSHIYUKI ISHIKAWA SHINICHI SUMITA KAZUO KIMURA MIYAKO KIKUCHI MASAMI KOSUGE NAOMITSU KUJI TSUTOMU ENDO TERUYASU SUGANO TOMOHIKO SIGEMASA IZUMI KOBAYASHI OSAMU TOCHIKUBO TAKASHI USUI 《Pacing and clinical electrophysiology : PACE》1999,22(9):1365-1371
In patients with an implanted DDD pacemaker (PM), the atrial contribution may be interrupted by too short an atrioventricular (AV) delay, and filling time may be shortened by too long an AV delay. The AV delay at which the end of the A wave on transmitral flow coincides with complete closure of the mitral valve may be optimal. The subjects were 15 patients [70.3+/-12.3 (SD) years old] with an implanted DDD PM. Cardiac output (CO) and pulmonary capillary wedge pressure (PCWP) were measured by Swan-Ganz catheter. Transmitral flow was recorded by pulsed Doppler echocardiography. AV delay was prolonged stepwise by 25 msc. When the AV delay was set at 155+/-26 ms, the end of the A wave coincided with complete closure of the mitral valve. When the AV delay was prolonged 25, 50, 75, and 100 ms from this AV delay, the interval between the end of the A wave and complete closure of mitral the valve was prolonged 16+/-5, 39+/-6, 65+/-4 and 88+/-5 ms, respectively (r = 0.97, P<0.0001) and diastolic mitral regurgitation was observed during this period. Thus, the optimal AV delay may be predicted as follows: the slightly prolonged AV delay minus the interval between the end of the A wave and complete closure of the mitral valve. When the AV delay was set at 215 ms, there was a significant positive correlation between the predicted optimal AV delay (166+/-23 ms) and the optimal AV delay (CO: 161+/-26 msec, r = 0.93, P<0.0001, PCWP: 161+/-28 msec, r = 0.95, P<0.0001). In conclusion, optimal AV delay can be predicted by this simple formula: slightly prolonged AV delay minus the interval between end of A wave and complete closure of mitral valve at the AV delay setting. 相似文献
190.
PREDICTION OF THE THERAPEUTIC DOSE FOR BENZODIAZEPINE ANXIOLYTICS BASED ON RECEPTOR OCCUPANCY THEORY
KIYOMI ITO AKIKO ASAKURA YASUHIKO YAMADA KOUICHI NAKAMURA YASUFUMI SAWADA TATSUJI IGA 《Biopharmaceutics & drug disposition》1997,18(4):293-303
Many benzodiazepines (BZPs) are now used as anxiolytics with nearly 200-fold variety of therapeutic doses. The variation of the doses of BZPs is due to differences both in their pharmacokinetics and in their receptor binding characteristics. The purpose of this study is to clarify the mechanism of the differences in therapeutic dose by retrospective analyses and to develop a system for the quantitative estimation of optimal doses of BZPs. The values of receptor dissociation constant (Kd), which indicates the binding affinity of each BZP at the receptor site, were obtained from a number of works based on in vitro binding experiments. The plasma unbound concentrations of the BZPs and their active metabolites were calculated using the reported values of their total plasma concentrations after average oral doses of the BZPs and the values of their plasma unbound fractions, which were also taken from the literature. There were log-linear relationships between the Kd values of BZPs and their average therapeutic doses or maximum plasma concentrations, but the correlation coefficients were relatively small (r >0·77). In contrast, a good log-linearity (r =0·96) was observed in the correlation between their Kd values and the effective plasma unbound concentrations considering the active metabolites. This finding indicates that the receptor occupancy after administration of therapeutic dose of BZPs is consistent (52·3±3·2%) among the BZPs. In this study, we also develop a possible system for estimating the appropriate doses of BZPs based on receptor occupancy theory. ©1997 by John Wiley & Sons, Ltd. 相似文献