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101.
Hepatic HCV-RNA as a predictor of outcome after interferon therapy in patients with chronic hepatitis C 总被引:2,自引:0,他引:2
MASAAKI KONDO KATSUAKI TANAKA MASANORI IKEDA SHINJU ARATA SATORU SAITO TAKASHI SAKAGUCHI MANABU MORIMOTO TAKANDO FUJII KONOMI MITSUI HIROSHI OKAZAKI MASATO HOSHINO HISAHIKO SEKIHARA 《Journal of gastroenterology and hepatology》1996,11(3):236-240
Measurement of serum HCV-RNA is a useful index for evaluating the antiviral effect of interferon therapy in chronic hepatitis C. In the present study, we investigated whether the detection of hepatic HCV-RNA after interferon treatment, using a polymerase chain reaction assay, predicted long-term response to therapy in patients with chronic hepatitis C. Thirty-three patients underwent liver biopsies before and after interferon therapy. Histology and clinical courses were compared after treatment. Before therapy, serum and hepatic HCV-RNA was detected in specimens from 32 (97%) and 33 (100%) patients, respectively. Serum HCV-RNA became undetectable in samples from 22 (67%) patients; however, in 10 of these patients (45%), serum HCV-RNA levels relapsed after therapy. Hepatic HCV-RNA became undetectable in 14 patients after therapy and the serum aminotransferase concentration remained within normal limits during and following (24–92 weeks) therapy in 12 of these patients (86%). All 11 patients with detectable hepatic HCV-RNA also had serum HCV-RNA and elevated aminotransferase concentrations refractory to therapy. The absence of hepatic HCV-RNA at the end of interferon treatment thus predicted a long-term complete response to therapy with a sensitivity of 100%, a specificity of 90% and an accuracy of 94%. We conclude that hepatic rather than serum HCV-RNA is a more useful index for the prediction of the long-term efficacy of interferon therapy. 相似文献
102.
WATARU SHIMIZU M.D. TOHRU OHE M.D. TAKASHI KURITA M.D. TAKAHIRO TOKUDA M.D. KATSURO SHIMOMURA M.D. 《Journal of cardiovascular electrophysiology》1994,5(5):438-444
Epinephrine-Induced VPCs and EADs in Congenital LQTS. We report a patient with congenital long QT syndrome in whom early afterdcpolarizations (RAl)s) were demonstrated on monophasic action potential (MAP) recordings in the left ventricular mid-base inferior wall. Epinephrine infusion at 5 fig/mm increased the amplitude of the EADs and the late component of the T(U) wave. Epinephrine also induced ventricular premature complexes (VPCs) with right hundle branch block morphology and left-axis deviation that occurred from the peak of the EADs. Verapamil injection (5 nig) during continuous epinephrine infusion abolished all VPCs with a slight reduction in the amplitude of the EADs. Propranolol injection (5 mg) in addition to verapamil further reduced the amplitude of the EADs and the late component of the T(U) wave. These findings suggest that the epinephrinc-induced VPCs were closely related to triggered rhythm arising from the EADs, and that both verapumil and propranoloi were effective for the suppression of VPCs and EADs. 相似文献
103.
NAOMI MIZUTANI M.D. YASUHIKO MASUDA M.D. NARIAKI NAITO M.D. TAKASHI TODA M.D. EI-ICHIRO YAO M.D. MANABU FUKUMOTO M.D. † 《The American journal of gastroenterology》1981,76(2):141-144
A 39-year old woman, with a pancreatic arteriovenous malformation (AVM) which ruptured into the pancreatic duct, was treated successfully with distal pancreatectomy and splenectomy. Histological examinations revealed an AVM with extravasation into the pancreatic ducts. A review of the cases reported to date emphasizes the importance of physical signs, individual histories and angiographic studies for early diagnosis and surgery. 相似文献
104.
Class IC Antiarrhythmic Drugs, Flecainide and Pilsicainide, Produce ST Segment Elevation Simulating Inferior Myocardial Ischemia 总被引:1,自引:0,他引:1
WAKO NAKAMURA M.D. KAZUHIKO SEGAWA M.D. HIROYUKI ITO M.D. SHUGO TANAKA M.D. NOBUO YOSHIMOTO M.D. 《Journal of cardiovascular electrophysiology》1998,9(8):855-858
ST Elevation with Flecainide and Pilsicainide . Flecainide and pilsicainide, Class IC antiarrhythmic drugs with slow kinetics, were administered to a 64-year-old man experiencing ventricular tachycardia. Both drugs suppressed the arrhythmia, but caused ST segment elevation in leads II, III, and aVF. No evidence of ischemic heart disease was detected. Withdrawal of the drugs eliminated the ST change. Because these drugs frequently are used to treat tachyarrhythmias in patients who may present with chest pain, this rare ECG manifestation of Class IC drugs should he recognized to avoid misdiagnosis of acute interior myocardial infarction. 相似文献
105.
KIYOTAKA MATSUO M.D. WATARU SHIMIZU M.D. TAKASHI KURITA M.D. KAZUHIRO SUYAMA M.D. NAOHIKO AIHARA M.D. SHIRO KAMAKURA M.D. KATSURO SHIMOMURA M.D 《Journal of cardiovascular electrophysiology》1998,9(1):74-83
Increased Dispersion of RT in Familial Idiopathic VF. Introduction: The role of increased dispersion of repolarization in the genesis of torsades de pointes in patients with long QT syndrome has been clarified, but its role in the genesis of idiopathic ventricular fibrillation (VF) is not yet known. To investigate the pathogenesis of VF, we recorded monophasic action potentials (MAPs) from two siblings (48- and 36-year-old males) with familial idiopathic VF. Methods and Results: The elder brother (patient I) showed a late r’ wave in lead V1 and ST segment elevation in leads V1 through V3. The younger brother (patient 2) had late r’ waves and ST segment elevation in leads II, III, and aVF, and the configurations were very similar to those of patient I. MAPs were recorded from several sites in the right ventricular (RV) and left ventricular (LV) endocardium during constant right atrial pacing. The repolarization time (RT) was defined as the sum of the activation time (AT) and action potential duration (APD) at 90% repolarization. In patient 1, marked prolongation of the AT (140 msec) and the RT (380 msec) was recorded in the RV septum of the outflow tract, and the RT dispersion was markedly increased (125 msec). In contrast, patient 2 showed prolongation of the AT (80 msec) and RT (310 msec), and fractionated electrograms in the RV floor of the inflow tract. The RT dispersion was also increased (80 msec). VF and nonsustained polymorphic ventricular tachycardia were induced by double premature stimulation in patients 1 and 2, respectively. Chronic amiodarone therapy decreased the RT dispersion and suppressed the induction of ventricular tachyarrhythmias in patient 2, although late r’ waves and slight ST segment elevation were unmasked in leads V1, and V2. Conclusion: Our data suggest that the increased dispersion of the RT, which was due mainly to a localized conduction delay in the RV, created an arrhythmogenic substrate in the two patients with familial idiopathic VF. 相似文献
106.
107.
YOSHIO FURUKAWA M.D. Ph.D. TAKAHISA YAMADA M.D. Ph.D. TAKASHI MORITA M.D. Ph.D. YUSUKE IWASAKI M.D. MASATO KAWASAKI M.D. ATSUSHI KIKUCHI M.D. TAKASHI NAITO M.D. TADAO FUJIMOTO M.D. KENTARO OZU M.D. TAKUMI KONDO M.D. KAORUKO SENGOKU M.D. HIRONORI YAMAMOTO M.D. TOHRU MASUYAMA M.D. Ph.D. F.A.C.C. MASATAKE FUKUNAMI M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2013,24(6):632-639
108.
109.
FUMIO YAMASHITA DAISAKU URABE HARUMICHI ITO SHIGENOBU KONDO YOSHIYUKI HANAWA 《Pediatrics international》1993,35(6):543-548
The experience gained during 7 years of cooperation between the Japan International Cooperation Agency (JICA) and the Islamabad Children's Hospital (JICA-ICH project, July 1986-June 1993) is described. Islamabad Children's Hospital achieved the goals of the project and became a centre for excellence in health care, education and research for children, fulfilling the objectives of the project. This achievement was evaluated as one of the most successful projects in medical cooperation ever performed by JICA by a third party evaluation team. The problems arising and the lessons experienced through the process are discussed. The importance of the role which should be undertaken by pediatricians in international cooperation with developing countries is emphasized. 相似文献
110.
TAKASHI MIZUMA SATOSHI MASUBUCHI SHOJI AWAZU 《The Journal of pharmacy and pharmacology》1998,50(2):167-172
Intestinal absorption of four cyclic dipeptides was studied in the everted small intestine of the rat. Cyclic seryltyrosine (cyclo(Ser-Tyr)) was stable enough to be transported whereas linear seryltyrosine was not. The absorption clearance of cyclo(Ser-Tyr) was concentration-dependent, and for cyclo(Ser-Tyr) at 125 μM decreased in the presence of glycylsarcosine (10 mM) or cephalexin (10 mM), which were reported to be absorbed by oligopeptide transporter. The absorption clearance was also reduced at 4°C and in the presence of 1 mM dinitrophenol. Kinetic analysis of cyclo(Ser-Tyr) absorption showed that Km and Vmax were 19.8 μM and 0.295 nmol min?1 cm?1, respectively. It was also suggested that cyclic aspartylphenylalanine and cyclic histidylphenylalanine were absorbed by oligopeptide transporters, but cyclic histidylproline was not. The absorption clearance of cyclo(Ser-Tyr) in the control was much higher than the value of the correlation line representing a plot of passive transport (which was obtained from the absorption clearance of cyclic peptides in the presence of glycylsarcosine (10 mM)) against hydrophobicity (oil-water partition coefficient). These results indicate that cyclo(Ser-Tyr) is absorbed by the oligopeptide transporter. 相似文献