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991.
992.
Michiyuki Saito Kazuhiko Yoshida Wataru Saito Akio Fujiya Kazuhiro Ohgami Nobuyoshi Kitaichi Hiroki Tsukahara Susumu Ishida Shigeaki Ohno 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2012,250(2):239-245
Purpose
Previous studies have reported that astaxanthin (AXT) has antioxidative and anti-inflammatory effects in addition to its ability to shorten blood transit times. As laser speckle flowgraphy (LSFG) can noninvasively visualize the hemodynamics of the choroidal circulation, we used the technique to evaluate whether continuous ingestion of 12 mg of AXT per day could increase quantitative blood flow velocity. 相似文献993.
Daiju Iwata Kenichi Namba Kazuomi Mizuuchi Nobuyoshi Kitaichi Satoru Kase Yuko Takemoto Shigeaki Ohno Susumu Ishida 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2012,250(7):1081-1087
Background
Infliximab, an anti-TNF-α monoclonal antibody, administered to Beh?et’s disease (BD) patients in Japan with refractory intraocular inflammation, has shown excellent clinical results. However, some patients demonstrate a decreased response to infliximab during the course of the treatment. In the present study, we investigated the correlation between this reduced therapeutic effect and elevation of the serum antinuclear antibody (ANA) titers in patients with BD who were undergoing infliximab therapy.Methods
Seventeen patients (14 males and three females) with uveitis in BD who were undergoing treatment with infliximab for 2?years or longer were enrolled. Their blood test results and clinical histories were obtained from medical records.Results
One patient (5.9%) was ANA-positive prior to the initiation of infliximab, and 11 patients (64.7%) developed positive ANA during the therapy. The appearance of ANA was observed 6?months after the initiation of the infliximab therapy, and its titers gradually increased. None of the patients showed lupus symptoms. Five patients (29.4%) have suffered from ocular inflammatory attacks since the sixth month from the initiation of infliximab treatment and all of them were ANA-positive. In contrast, four patients (23.5%) who were ANA-negative experienced no ocular attacks during the follow-up period.Conclusions
Here we report the positive conversion and subsequent elevation of serum ANA titers in some patients with BD after the initiation of infliximab therapy. Since all recurrences of uveitis were shown only in the ANA-positive patients, serum ANA titer may be a helpful biomarker for predicting the recurrence of ocular attacks in BD patients treated with anti-TNF-α antibody therapies. 相似文献994.
Yasunori Nawa Wataru Inami Aki Miyake Atsushi Ono Yoshimasa Kawata Sheng Lin Susumu Terakawa 《Biomedical optics express》2014,5(2):378-386
We developed a high-resolution fluorescence microscope in which fluorescent materials are directly excited using a focused electron beam. Electron beam excitation enables detailed observations on the nanometer scale. Real-time live-cell observation is also possible using a thin film to separate the environment under study from the vacuum region required for electron beam propagation. In this study, we demonstrated observation of cellular components by autofluorescence excited with a focused electron beam and performed dynamic observations of intracellular granules. Since autofluorescence is associated with endogenous substances in cells, this microscope can also be used to investigate the intrinsic properties of organelles.OCIS codes: (110.0180) Microscopy, (170.0180) Microscopy, (170.2520) Fluorescence microscopy, (180.2520) Fluorescence microscopy, (180.5810) Scanning microscopy 相似文献
995.
Yoshida K Ueda M Yamazaki H Takenaka T Yoshida M Miyake S Yoshida S Koizumi M Ban C Tanaka E 《Journal of radiation research》2012,53(1):154-158
To expand the indications for high-dose-rate interstitial brachytherapy (HDR-ISBT) for deep-seated pelvic tumors, we investigated the usefulness of Doppler transrectal ultrasonography (TRUS) guidance and virtual planning. The patient was a 36-year-old female. She had right internal iliac lymph node oligometastasis of vaginal cancer 12 months after radical radiotherapy. The tumor could not be found by gray-scale TRUS and physical examination. Virtual planning was performed using computed tomography with template and vaginal cylinder insertion. We uploaded the images to our treatment planning software and reconstructed the contours of the clinical target volume (CTV) and right internal iliac vessel. Virtual needle applicators were plotted using the template holes for virtual planning. At the time of implantation, Doppler TRUS was used to prevent vessel injury by needle applicators. Applicators were implanted in accordance with virtual planning and Doppler TRUS could detect the right iliac vessel. The percentage of CTV covered by the prescribed dose was 99.8%. The minimum dose received by the maximally irradiated 0.1-cc volume for the right internal iliac vessel was 95% prescribed dose. Complete response was achieved, however, radiological findings showed marginal recurrence at 15 months after HDR-ISBT. Post-radiation neuropathy occurred as a late complication four months after treatment; however, the pain was well controlled by medication. We consider that virtual planning and Doppler TRUS are effective methods in cases where it is difficult to detect the tumor by physical examination and gray-scale TRUS, thereby expanding the indications for ISBT. 相似文献
996.
Rina Tamai Tomoya Hara Hirotsugu Yamada Susumu Nishio Mika Bando Junko Hotchi Shuji Hayashi Toshiyuki Niki Tetsuya Kitagawa Masataka Sata 《Journal of Medical Ultrasonics》2014,41(1):69-71
An 83-year-old woman presented to our echocardiographic center with symptoms of right heart failure. A dual-chamber DDDR pacemaker had been implanted 9 years earlier. Two-dimensional echocardiography revealed right atrial and ventricular enlargement and massive tricuspid regurgitation with immobilization of the anterior leaflet of the tricuspid valve. Three-dimensional transesophageal echocardiography showed that the pacemaker lead had punctured the leaflet. These echocardiographic findings were confirmed during surgery. The pacemaker lead was transected and removed, and pericardial patch closure of the leaflet hole and tricuspid annuloplasty were performed. The mechanism of regurgitation was elucidated by real-time three-dimensional echocardiography, and surgical repair was straightforward. 相似文献
997.
Dr. Koji Takeuchi PhD Youichi Nobuhara MA Susumu Okabe PhD 《Digestive diseases and sciences》1985,30(11):1072-1078
Influence of luminal Ca2+ on the integrity of normal mucosa and recovery of damaged mucosa in anesthetized rat stomachs was studied using a perfusion system. Changes in the mucosal integrity were monitored by measuring transmucosal potential difference (PD) and luminal pH. EDTA, a Ca2+ chelator, dose-dependently reduced PD and increased luminal pH. Five mM Ca2+ (CaCl2) alone produced no changes in either PD and luminal pH, but the PD which was reduced by 250 mM EDTA was significantly recovered. Ethanol or NaCl concentration-dependently reduced PD, but gradually reverted to baseline levels. While 5 mM Ca2+ or 5 mM EDTA did not influence the reduction in PD with 50% ethanol or 1 M NaCl, these agents either enhanced or delayed the recovery processes in reduced PD, respectively. Five mM Ca2+ enhanced the recovery of PD which was reduced by 50% ethanol plus 5 mM EDTA. Gastric damage induced by 50% ethanol plus 5 mM EDTA was much more severe than that induced by 50% ethanol alone or 50% ethanol plus 5 mM Ca2+. Both 50% ethanol and 1 M NaCl significantly increased Ca2+ contents in the gastric lumen. Luminal Ca2+ appears to play an important role in maintaining mucosal integrity, under normal physiological conditions, and in accelerating the recovery process of damaged mucosa in rat stomachs. 相似文献
998.
Hiroshi Mabuchi Ryozo Tatami Toshihiro Haba Kosei Ueda Ryosei Ueda Tomio Kametani Seigo Itoh Junji Koizumi Masayuki Oota Susumu Miyamoto Ryoyu Takeda Haruo Takeshita 《The American journal of medicine》1978,65(2):290-297
Fifty-one homozygous patients with familial hypercholesterolemia, including our six patients, are described in this paper. Twenty were men and 31 were women. Their ages ranged between two and 52 years, with a mean of 16.8 years. Six patients exceeded the third decade. The mean age at death in seven patients was 17 years. The serum cholesterol levels were between 508 and 1,108 mg/dl. The mean and standard deviation (SD) of serum cholesterol were 713 ± 142 mg/dl. The serum cholesterol levels in the 35 parents (obligate heterozygotes) were between 246 and 571 mg/dl, except in one patient in whom the serum cholesterol level (936 mg/dl) was suggestive of homozygous familial hypercholesterolemia, considering the serum cholesterol level (354 mg/dl) of her heterozygous husband. The mean and SD of serum cholesterol levels of the 34 heterozygote parents were 342 ± 79 mg/dl. The mean and SD of serum cholesterol in 119 normal subjects were 187 ± 30 mg/dl. Thus, trimodai distribution was evident in the serum cholesterol levels of normal subjects, the heterozygotes and the homozygotes in Japan. The frequency of parental consanguinity was at least 33 per cent. The frequencies of ischemic heart disease in the age groups 0–9, 10–19 and above 20 years were 25 per cent (four of 16 patients), 33 per cent (six of 18 patients) and 53 per cent (nine of 17 patients), respectively. The frequency of homozygotes in Japan was in close accordance with those of Western countries. Therefore, the treatment of hypercholesterolemia and prevention of premature coronary heart disease in familial hypercholesterolemic patients are very important problems in Japan as well as in the West. 相似文献
999.
Kimitoshi Kato M.D. Tomoaki Watanabe Masahiko Itoh Shuntaro Yoshida Naohisa Hoshino Kazuro Itoh Fumiaki Sugimura Ariyoshi Iwasaki Yutaka Matsuo Hiroko Sawai Shigeyuki Imai Susumu Oshiba Atsuko Seki 《Journal of gastroenterology》1990,25(3):314-319
We investigated the role of the autonomic nervous system in gastric acid secretion, somatostatin concentration and PAS-positive
mucus production in Brunner’s glands in cysteamine-induced duodenal ulcer. Vagotomized rats were used. No ulcers occurred
in the groups with vagotomies of the hepatoduodenal, truncal or gastric branches after cysteamine administration. However,
in the hepatoduodenal branch vagotomized group, there was an increases in gastric acid secretion after cysteamine administration.
A similar increase was observed in the control group, but the decreases in somatostatin concentration and PAS-positive mucus
seen in the control group were not found in the hepatoduodenal vagotomized group. These results suggest that the hepatoduodenal
branch of the vagus nerve might play an important role in the ulcerogenic process of cysteamine-induced duodenal ulcer. 相似文献
1000.