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471.
Brack W Bláha L Giesy JP Grote M Moeder M Schrader S Hecker M 《Environmental toxicology and chemistry / SETAC》2008,27(3):519-528
Contamination of Elbe River (Germany) sediments with dioxin-like toxicants was investigated following the 500-year flood (flood that statistically occurs once in 500 years) of 2002. It was hypothesized that large amounts of particulate matter from river beds and associated dioxin-like toxicants were mobilized and transported during this flood event. The investigation focused on polychlorinated naphthalenes (PCNs) that have not been determined previously in the Elbe River. The in vitro H4IIE-luc assay was used as an overall measure for toxicants capable of binding to the aryl hydrocarbon receptor (AhR). The assay was combined with congener-specific instrumental analyses and fractionation to quantify PCN contributions to total AhR-mediated activity relative to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs). Penta- to octachloronaphthalene concentrations of 30 ng/kg dry weight up to 13 microg/kg dry weight were found in Elbe River sediments downstream of Bitterfeld. Concentrations of penta- to octachloronaphthalenes, however, were only approximately 3 microg/kg dry weight at a site in the vicinity of Bitterfeld, where a level of approximately 3 mg/kg dry weight was reported before the flood. Also, the congener pattern of PCNs at this site changed after the flood, and PCN patterns reported previously for Bitterfeld and assigned to chlor-alkali electrolysis with graphite electrodes could now be observed at the sites from downstream of Bitterfeld and Magdeburg. Whereas PCDD/Fs dominated the dioxin-like activity in the middle and lower Elbe River, PCNs contributed as much as 10% of the total AhR-mediated activity. The contribution of PCBs was less significant (maximum, 0.2%). Thus, in Elbe River sediments, PCNs should be considered as relevant contaminants and be included in future monitoring and risk assessment programs. 相似文献
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474.
Benny Abraham Kaipparettu Klaudia M Dobrzycka Ora Britton Adrian V Lee Alan J Herron Yi Li Michael T Lewis Daniel Medina Steffi Oesterreich 《Molecular cancer》2009,8(1):15-11
Background
Scaffold Attachment Factor B1 (SAFB1) is a multifunctional protein which has been implicated in breast cancer previously. We recently generated SAFB1 knockout mice (SAFB1-/-), but pleiotropic phenotypes including high lethality, dwarfism associated with low IGF-I levels, and infertility and subfertility in male and female mice, respectively, do not allow for straightforward tumorigenesis studies in these mice. Therefore, we asked whether SAFB1 heterozygosity would influence tumor development and progression in MMTV-Wnt-1 oncomice or DMBA induced tumorigenicity, in a manner consistent with haploinsufficiency of the remaining allele. 相似文献475.
476.
Tobias Luck Priv.‐Doz. Dr. rer. med. Steffi G. Riedel‐Heller Prof. Dr. med. Susanne Roehr MSc Birgitt Wiese Dipl.‐Math. Carolin van der Leeden Dipl.‐Psych. Kathrin Heser Dr. phil. Horst Bickel Dr. phil. Michael Pentzek Dr. rer. nat. Hans‐Helmut König Prof. Dr. med. Jochen Werle Dr. phil. Silke Mamone BA Tina Mallon MA Steffen Wolfsgruber Dr. phil. Dagmar Weeg Dr. med. Angela Fuchs Dipl.‐Psych. Christian Brettschneider Dr. rer. Biol. Hum. Martin Scherer Prof. Dr. med. Wolfgang Maier Prof. Dr. med. Siegfried Weyerer Prof. Dr. phil. the AgeCoDe study group 《Journal of the American Geriatrics Society》2017,65(4):738-746
477.
Barbara Teutsch Anja Berger Durdica Marosevic Katharina Schönberger Thiên-Trí Lâm Kerstin Hubert Steffi Beer Peter Wienert Nikolaus Ackermann Heike Claus Maria Drayß Kathrin Thiel Mark van der Linden Ulrich Vogel Andreas Sing 《Infection》2017,45(5):607-611
Purpose
The prevalence of protective anti-diphtheria toxin antibodies decreases with age. Therefore, the elderly might serve as reservoir for potentially toxigenic Corynebacterium (C.) species (C. diphtheriae, C. ulcerans, and C. pseudotuberculosis). This study aimed to examine the colonization rate of the nasopharynx with corynebacteria of individuals aged 65 years and older.Methods
In the period from October 2012 to June 2013, nasal and throat swabs were taken from 714 asymptomatic subjects aged 65–106 years (average age 77.2) at three regions in Germany and investigated for Corynebacterium species.Results
A total of 402 strains of Corynebacterium species were isolated from 388 out of 714 asymptomatic subjects (carriage rate 54.3%). The carriage rate was significantly higher in study participants living in retirement homes (68.4%) compared to those living autonomously at home (51.1%). Strains were isolated mostly from the nose (99%). Corynebacterium accolens was the most often isolated species (39.8%), followed by C. propinquum (24.1%), C. pseudodiphtheriticum (19.4%), and C. tuberculostearicum (10.2%). No C. diphtheriae, C. ulcerans, and C. pseudotuberculosis strains were isolated. A subsample of 74 subjects was tested serologically for anti-diphtheria antibodies. Protective anti-diphtheria toxin antibodies were found in 29.7% of the subjects; 70.3% showed no protective immunity.Conclusions
These results suggest that carriage of potentially toxigenic corynebacteria is very rare among people aged 65 and older in Germany. However, the low prevalence of protective anti-diphtheria toxin antibodies might pose a risk for acquiring diphtheria especially for the elderly.478.
Stephanie Stadelmann Madlen Grunewald Charlotte Gibbels Sonia Jaeger Tina Matuschek Steffi Weis Annette Maria Klein Andreas Hiemisch Kai von Klitzing Mirko Döhnert 《Child psychiatry and human development》2017,48(1):40-52
In this study, we investigated the relation between global and domain-specific self-esteem and psychiatric disorders. A sample of 577 children aged 8–14 years was recruited via psychiatric hospitals and from the general population. Parents were given a diagnostic interview to assess children’s psychiatric diagnoses (current/past). Parents and children completed questionnaires on child symptoms. Children completed a questionnaire on global and domain-specific self-esteem (scales: scholastic competence, social acceptance, athletic performance and physical appearance, global self-esteem). Self-esteem of children with current psychiatric disorders was lower than that of healthy controls (η p 2 between 0.01 and 0.08). Concerning scholastic competence, social acceptance and global self-esteem, children with past psychiatric disorders scored also lower than healthy controls. Different current psychiatric disorders showed specific but small effects on dimensions of self-esteem (β between ?0.08 and 0.19). Moreover, we found a gender × group interaction, indicating that girls with depressive and adjustment disorders were specifically impaired in their global self-esteem and perception of their physical appearance. Findings might help clinicians to focus on particular domains of self-esteem during the diagnostic process and to define adequate treatment goals. 相似文献
479.
Effect of Visual Impairment on Physical and Cognitive Function in Old Age: Findings of a Population‐Based Prospective Cohort Study in Germany 下载免费PDF全文
André Hajek PhD Christian Brettschneider PhD Dagmar Lühmann MD Marion Eisele PhD Silke Mamone BA Birgitt Wiese MSc Siegfried Weyerer PhD Jochen Werle PhD Michael Pentzek PhD Angela Fuchs MSc Steffi G. Riedel‐Heller MD MPH Tobias Luck PhD PD Horst Bickel PhD Dagmar Weeg MD Alexander Koppara MSc Michael Wagner PhD Martin Scherer MD Wolfgang Maier MD Hans‐Helmut König MD MPH the Study on Ageing Cognition Dementia in Primary Care Patients Group 《Journal of the American Geriatrics Society》2016,64(11):2311-2316