全文获取类型
收费全文 | 142篇 |
免费 | 9篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 17篇 |
妇产科学 | 7篇 |
基础医学 | 13篇 |
口腔科学 | 5篇 |
临床医学 | 24篇 |
内科学 | 31篇 |
皮肤病学 | 2篇 |
神经病学 | 5篇 |
特种医学 | 16篇 |
外科学 | 14篇 |
综合类 | 4篇 |
预防医学 | 6篇 |
药学 | 5篇 |
肿瘤学 | 3篇 |
出版年
2023年 | 2篇 |
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 2篇 |
2017年 | 2篇 |
2015年 | 3篇 |
2014年 | 4篇 |
2013年 | 5篇 |
2012年 | 3篇 |
2011年 | 5篇 |
2010年 | 2篇 |
2009年 | 10篇 |
2008年 | 6篇 |
2007年 | 3篇 |
2006年 | 2篇 |
2005年 | 7篇 |
2004年 | 4篇 |
2003年 | 7篇 |
2002年 | 5篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1999年 | 4篇 |
1998年 | 7篇 |
1997年 | 5篇 |
1996年 | 6篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 7篇 |
1992年 | 2篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1973年 | 1篇 |
1965年 | 1篇 |
1962年 | 1篇 |
1948年 | 1篇 |
排序方式: 共有152条查询结果,搜索用时 156 毫秒
61.
62.
WT Cade DN Reeds KE Mondy ET Overton J Grassino S Tucker C Bopp E Laciny S Hubert S Lassa‐Claxton KE Yarasheski 《HIV medicine》2010,11(6):379-388
Objective
People living with HIV infection are at increased risk for developing cardiovascular disease (CVD). Safe and effective interventions for lowering CVD risk in HIV infection are high priorities. We conducted a prospective, randomized, controlled study to evaluate whether a yoga lifestyle intervention improves CVD risk factors, virological or immunological status, or quality of life (QOL) in HIV‐infected adults relative to standard of care treatment in a matched control group.Methods
Sixty HIV‐infected adults with mild–moderate CVD risk were assigned to 20 weeks of supervised yoga practice or standard of care treatment. Baseline and week 20 measures were: 2‐h oral glucose tolerance test with insulin monitoring, body composition, fasting serum lipid/lipoprotein profile, resting blood pressures, CD4 T‐cell count and plasma HIV RNA, and the Medical Outcomes Study Short Form (SF)‐36 health‐related QOL inventory.Results
Resting systolic and diastolic blood pressures improved more (P=0.04) in the yoga group (−5 ± 2 and −3 ± 1 mmHg, respectively) than in the standard of care group (+1 ± 2 and+2 ± 2 mmHg, respectively). However, there was no greater reduction in body weight, fat mass or proatherogenic lipids, or improvements in glucose tolerance or overall QOL after yoga. Immune and virological status was not adversely affected.Conclusion
Among traditional lifestyle modifications, yoga is a low‐cost, simple to administer, nonpharmacological, popular behavioural intervention that can lower blood pressure in pre‐hypertensive HIV‐infected adults with mild–moderate CVD risk factors.63.
Egea CJ Aizpuru F Pinto JA Ayuela JM Ballester E Zamarrón C Sojo A Montserrat JM Barbe F Alonso-Gomez AM Rubio R Lobo JL Duran-Cantolla J Zorrilla V Nuñez R Cortés J Jiménez A Cifrián J Ortega M Carpizo R Sánchez A Terán J Iglesias L Fernández C Alonso ML Cordero J Roig E Pérez F Muxi A Gude F Amaro A Calvo U Masa JF Utrabo I Porras Y Lanchas I Sánchez E;Spanish Group of Sleep Breathing Disorders 《Sleep medicine》2008,9(6):660-666
Background and purposeContinuous positive airway pressure (CPAP) is an effective treatment for sleep apnea (SA), although the evidence for improving chronic heart failure (CHF) is inconclusive. Our aim was to evaluate the effect of CPAP treatment on the left ventricle ejection fraction (LVEF) among other cardiological variables in a randomized, multicenter, placebo (sham-CPAP)-controlled study.MethodsAfter the selection procedure, 60 patients with CHF with LVEF < 45% and SA with an apnea–hypopnea index (AHI) > 10/h were evaluated at baseline, and after 3 months of treatment with optimal CPAP or sham-CPAP. The assessment was based on the LVEF, hypertension, daytime sleepiness (Epworth sleepiness scale [ESS]), quality of life (SF-36), New York Heart Scale (NYHA score), dyspnea (by using the Borg scale) and exercise tolerance (6-min walk test).ResultsThe mean AHI was normalized in the optimal CPAP group but not in the sham-CPAP group. The LVEF showed a significant improvement in the group of patients treated with CPAP (2.5; 95% CI: 0.6 to 4.3), which was not observed in the sham-CPAP group (0.0; 95% CI: −2.1 to 2.1). However, the change in the LVEF from baseline to 3 months was not significantly greater in the whole group (obstructive and Cheyne–Stokes events) treated with CPAP than in the control group (p: 0.07). In patients with only obstructive sleep apnea (OSA), who account for 83% of the total population, there was a significant improvement in the LVEF in the group of patients treated with CPAP but no such improvement in the sham-CPAP group. In this OSA group, the change in the LVEF from baseline to 3 months was significantly greater in the group treated with CPAP than in the sham-CPAP group (p: 0.03). The other variables studied were not modified. When the patients were divided according to the severity of the LVEF (a LVEF cut-off of 30%), improvement was observed in those with a LVEF > 30. No changes were found in the other cardiological variables.ConclusionsCPAP therapy proved to be useful in patients with associated sleep-disordered breathing and CHF. The improvement was more marked in patients with a LVEF > 30%. However, the increased LVEF in the CPAP group was not accompanied by changes in the other cardiological variables. 相似文献
64.
65.
Background
Polyurethane (PU) foam is widely used as a model for cancellous bone. The higher density foams are used as standard biomechanical test materials, but none of the low density PU foams are universally accepted as models for osteoporotic (OP) bone. The aim of this study was to determine whether low density PU foam might be suitable for mimicking human OP cancellous bone. 相似文献66.
The ovarian steroid hormone estradiol and its metabolite estrone were examined in 45 normal women and 127 premenopausal women with precancerous cervical lesions. Interviews, colposcopy and cervical scrapings were performed. The mean +/- SD values for estradiol and estrone were 0.07 +/- 0.08 ng/ml and 0.06 +/- 0.02 ng/ml, respectively in normal subjects. Corresponding data in patients with cervical intraepithelial neoplasia alone or in association with human papillomavirus (HPV) infection were 0.074 +/- 0.03 ng/ml and 0.076 +/- 0.03 ng/ml or 0.080 +/- 0.03 ng/ml and 0.148 +/- 0.02 ng/ml, respectively, which revealed a significantly greater extent of estrogenic action in the latter population (p < 0.05). We considered that the presence of HPV infection probably increased 16 alpha-hydroxylation of estradiol, providing a possible link between the viral and hormonal elements, possibly having a bearing on the etiology of the disease. 相似文献
67.
68.
69.
BACKGROUND: Increasing indications for warfarin therapy has led to
increased pressure on primary care to undertake therapeutic monitoring.
OBJECTIVE: This study evaluates a primary care model of oral
anticoagulation monitoring which utilises computerized decision support
(CDSS) and near patient testing (NPT) within a practice nurse-led clinic.
Whilst this has been shown to be a successful model under trial conditions,
this paper reports the first data from a long-standing clinic, outside a
formal study. METHOD: A prospective evaluation of therapeutic and clinical
control of all patients taking warfarin within one inner city general
practice. Data were collected via CDSS. RESULTS: 29 patients were seen in
208 appointments. The mean percentage of patients within therapeutic range
was 72%. The costs to the practice were pound sterling 1751. The costs the
practice would have incurred had these patients been seen at the hospital
with the same frequency would have been pound sterling 2290. CONCLUSIONS:
The use of CDSS and NPT for nurse-delivered oral anticoagulation monitoring
could enable the safe transfer of the majority of patients from secondary
to primary care. Funding mechanisms to support the transfer of costs will
be essential for most practices, as will be the maintenance of adequate
staff training and quality assurance.
相似文献
70.