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11.
Florian R. Schneider Alexander B. Mann Igor Konorov Gaspar Delso Stephan Paul Sibylle I. Ziegler 《Zeitschrift für medizinische Physik》2012,22(2):143-149
A one-day laboratory course on positron emission tomography (PET) for the education of physics students and PhD students in medical physics has been set up. In the course, the physical background and the principles of a PET scanner are introduced. Course attendees set the system in operation, calibrate it using a 22Na point source and reconstruct different source geometries filled with 18F. The PET scanner features an individual channel read-out of 96 lutetium oxyorthosilicate (LSO) scintillator crystals coupled to avalanche photodiodes (APD). The analog data of each APD are digitized by fast sampling analog to digital converters (SADC) and processed within field programmable gate arrays (FPGA) to extract amplitudes and time stamps. All SADCs are continuously sampling with a precise rate of 80 MHz, which is synchronous for the whole system. The data is transmitted via USB to a Linux PC, where further processing and the image reconstruction are performed. The course attendees get an insight into detector techniques, modern read-out electronics, data acquisition and PET image reconstruction. In addition, a short introduction to some common software applications used in particle and high energy physics is part of the course. 相似文献
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Alexandra D?nh?fer Sibylle Franckenberg Stephan Wickles Otto Berninghausen Roland Beckmann Daniel N. Wilson 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(42):16900-16905
Ribosome protection proteins (RPPs) confer tetracycline resistance by binding to the ribosome and chasing the drug from its binding site. The current model for the mechanism of action of RPPs proposes that drug release is indirect and achieved via conformational changes within the drug-binding site induced upon binding of the RPP to the ribosome. Here we report a cryo-EM structure of the RPP TetM in complex with the 70S ribosome at 7.2-Å resolution. The structure reveals the contacts of TetM with the ribosome, including interaction between the conserved and functionally critical C-terminal extension of TetM and the decoding center of the small subunit. Moreover, we observe direct interaction between domain IV of TetM and the tetracycline binding site and identify residues critical for conferring tetracycline resistance. A model is presented whereby TetM directly dislodges tetracycline to confer resistance. 相似文献
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Weber Matthias Banaschak Sibylle Rothschild Markus Alexander 《International journal of legal medicine》2021,135(1):313-322
International Journal of Legal Medicine - This paper describes the variety of information that a tool mark analysis on human tissue can provide based on a case of multiple sharp violence. The... 相似文献
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Feld Katharina Feld Dustin Karger Bernd Helmus Janine Schwimmer-Okike Nneka Pfeiffer Heidi Banaschak Sibylle Wittschieber Daniel 《International journal of legal medicine》2021,135(1):235-244
International Journal of Legal Medicine - The shaken baby syndrome (SBS) is a common variant of abusive head trauma (AHT) in infants and toddlers. Data on the legal outcome of such cases are still... 相似文献
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Defining the phenotype of young healthy nucleus pulposus cells: Recommendations of the Spine Research Interest Group at the 2014 annual ORS meeting 下载免费PDF全文