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81.
Wishwadewa Wirya Kemal M.D. Tsubara Yamada M.D. Shoichiro Shike M.D. 《Pediatrics international》1990,32(6):633-644
To evaluate hypodense eosinophils known very little in children, peripheral blood from asthmatic, allergic-non-asthmatic and non-allergic children was evaluated by density Percoll gradient techniques. A significantly higher number of eosinophils were hypodense in asthmatic children (n = 24) compared with allergic non-asthmatic (n = 10) and non-allergic children (n = 13), namely 484 ± 348 cells/40 μl versus 113 ± 109 and 39 ± 61 (p <0.001) respectively. We also observed by light and electron microscopy that the hypodense eosinophils of asthmatic children were swollen and their granules were dispersed, but the normodense eosinophils of the same patient were small and compact. In three cases of severe asthmatic attack, hypodense eosinophils found on admission decreased in number after intravenous aminophylline therapy and relief of symptoms. Moreover, a decreased number of hypodense eosinophils were found in seven cases of allergic children (p < 0.05) after 2 weeks of antiallergic drug treatment associated with relieved symptoms. From these data we concluded that the presence of hypodense eosinophils in the peripheral blood might be related to the development of allergic symptoms and might participate in the pathophysiology of allergic diseases in children. 相似文献
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HLA-DR-DQ haplotype in rapid-onset type 1 diabetes in Japanese 总被引:5,自引:0,他引:5
85.
Shinji Takahashi Masatoshi Hoshino Hidetomi Terai Hiromitsu Toyoda Akinobu Suzuki Koji Tamai Kyoei Watanabe Tadao Tsujio Hiroyuki Yasuda Hiroshi Kono Ryuichi Sasaoka Sho Dohzono Kazunori Hayashi Shoichiro Ohyama Yusuke Hori Hiroaki Nakamura 《Journal of orthopaedic science》2018,23(1):51-56
Background
Balloon kyphoplasty or vertebroplasty is widely performed as a surgical intervention for osteoporotic vertebral fracture (OVF) and the effects have been investigated in many previous studies. However, the influence of the timing of the procedure on patient outcomes has not been studied formally. The purpose of this study was to investigate differences in the surgical outcomes of OVFs according to the timing of balloon kyphoplasty.Methods
This was a multicenter cohort study. Participants comprised 72 consecutive patients who underwent balloon kyphoplasty between January 2012 and January 2016. Patients were analyzed in two groups according to the timing of kyphoplasty after onset (Early group: ≤2 months; Late group: >2 months). Follow-up continued for more than 6 months.Results
A total of 72 patients were effectively analyzed. Of these, 27 (38%) patients underwent kyphoplasty within 2 months after symptom onset. The Late group showed greater angular motion of fractured vertebrae (p = 0.005) and compression of anterior vertebral height (p = 0.001) before surgery. Final outcomes adjusted for age and preoperative outcome showed lower visual analog scale (VAS) scores for low back pain in the Early group than in the Late group (19.9 vs. 30.4, p = 0.049). Final relative anterior vertebral height and kyphotic angle were more preserved in the Early group than in the Late group (p = 0.002 and p = 0.020, respectively), although absolute differences were not significant.Conclusions
Vertebral height and kyphotic angle before and after balloon kyphoplasty were greater in patients who underwent kyphoplasty within 2 months after onset, and the VAS score for low back pain at final follow-up was better. Our results support kyphoplasty within 2 months. 相似文献86.
Narumi Tokaji Hiromichi Ito Tomohiro Kohmoto Takuya Naruto Rizu Takahashi Aya Goji Tatsuo Mori Yoshihiro Toda Masako Saito Shoichiro Tange Kiyoshi Masuda Shoji Kagami Issei Imoto 《American journal of medical genetics. Part A》2018,176(3):699-702
87.
Quantitative CT measurements of small pulmonary vessels in chronic obstructive pulmonary disease: do they change on follow‐up scans? 下载免费PDF全文
Shinji Saruya Shin Matsuoka Tsuneo Yamashiro Shoichiro Matsushita Atsuko Fujikawa Kunihiro Yagihashi Yasuyuki Kurihara Yasuo Nakajima 《Clinical physiology and functional imaging》2016,36(3):211-217
The aims of this study were to perform a longitudinal evaluation of the cross‐sectional area (CSA) of small pulmonary vessels and the extent of emphysema measured on computed tomography (CT) scans of patients with chronic obstructive pulmonary disease (COPD), and to correlate the pulmonary vascular measurements with extent of emphysema. The institutional review board approved this retrospective study and waived the need for patients' informed consent. Seventy‐four patients with COPD who underwent both initial and follow‐up CT scans at an interval of ≥12 months were analysed. The CSA of small pulmonary vessels <5 mm2 was measured, and the percentage of total CSA of the area of the lung (%CSA<5) was calculated. The extent of emphysema was assessed as the percentage of low attenuation area (%LAA, 950 Hounsfield units). Comparisons between initial and follow‐up measurements were performed using the Wilcoxon signed‐rank test. The relationship between longitudinal changes in %CSA<5 and %LAA during the follow‐up period was assessed using the Spearman rank correlation. The %LAA increased significantly on follow‐up CT scans (P<0·0001). The %CSA<5 was slightly decreased on follow‐up scans, but the difference was not significant. Although longitudinal change in %LAA was positively correlated with duration of follow‐up period (ρ = 0·505, P<0·0001), longitudinal change in %CSA<5 was not. In conclusion, there was a progressive increase in the extent of emphysema over time, but no significant decrease in the CSA of small pulmonary vessels over the same time period. 相似文献
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89.
Dr. Masafumi Kogire MD Kazutomo Inoue MD Ryuichiro Doi MD Shoichiro Sumi MD Kyoichi Takaori MD Mitsutoshi Yun MD Takashi Suzuki MD Takayoshi Tobe MD 《Digestive diseases and sciences》1988,33(5):592-597
Changes in hepatic and pancreatic blood flow in response to ethanol infusion were determined simultaneously and continuously in anesthetized dogs, using a transit-time ultrasonic flowmeter and a laser-Doppler flowmeter. In addition, the effect of intravenous ethanol on exocrine pancreatic secretion was investigated. With a background infusion of secretin, ethanol (1.3 g/kg body wt) was infused intravenously over a 40-min period. Ethanol infusion significantly increased blood flow in the common hepatic artery (by 49%, at the time of the cessation of ethanol infusion), and this increased flow was maintained for 60 min after the cessation of ethanol infusion. In contrast, blood flow in the portal vein was not altered significantly by ethanol. Pancreatic blood flow and secretion showed no significant difference from those seen in the controls. Our data suggest that intravenous ethanol induces a redistribution of the splanchnic blood flow. The increased hepatic arterial flow seen in response to ethanol may play an important role in preventing ethanol-induced hypoxic liver damage. 相似文献
90.
Uchikawa T Kumamoto Y Maruyama I Kumamoto S Ando Y Yasutake A 《The Journal of toxicological sciences》2011,36(1):121-126
To investigate the influence of Chlorella (Parachlorella beijerinckii) on the excretion and tissue accumulation of methylmercury (MeHg), we orally administered 5 mg/kg of MeHg chloride (4 mg Hg/kg) to female C57BL/6N mice (aged 10 weeks). The mice were housed in metabolism cages to collect urine and feces for 3 weeks with diets containing 0%, 5%, or 10% P. beijerinckii powder (BP) in a basal diet (CE-2). The lowered blood Hg levels in the 5% and 10% BP groups became significant compared to those of the control group (0% BP) as early as day 7. During the 21 days of testing, significant increases in the cumulative Hg eliminations into urine (5% BP) and feces (5% and 10% BP) were found in the BP groups. Twenty-one days after administration, the organ Hg levels in both BP groups tended to decrease compared to that of the control group. The reduction of Hg levels in the kidney and brain were significant, whereas that in the liver was not. Although tissue Hg levels are known to be closely related to glutathione (GSH) metabolism, no difference was found in GSH levels in the blood or organs between the control group and the 10% BP group. These results suggest that continuous BP intake accelerates the excretion of MeHg and subsequently decreases tissue Hg levels in mice, with no alteration of GSH metabolism. We should conduct further research to elucidate details regarding the mechanism of BP-induced enhancement of MeHg excretion. 相似文献