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71.
72.
Terukatsu Arima M.D. Chisato Mori Akihisa Takamizawa Takeyuki Nakajima Kouichi Kanai 《Journal of gastroenterology》1989,24(6):685-691
Fifty-six lambda gt11-random-primed-cDNA recombinants of which translation products react with antibodies in the serum drawn
from patients with hepatitis C (blood-borne non-A, non-B hepatitis) were cloned from serum pooled from donors presumably infected
with hepatitis C. The specificity of these clones for hepaitits C infection was determined using 3 test panels. Of these 29
clones were determined to be specific for Japanese hepatitis C infection. However one of the 29 clones was positive for 1
out of 5 normals in an American test panel while 12 clones were positive for the American panel as well. The remaining 28
clones reacted well with serum from transfusion associated chronic hepatitis C comparing to the sporadic cases in the Japanese
panel. When they were tested with normal donors, another clone reacted with a distinct donor group with which the other clones
did not react. These results may suggest the presence of heterogeneity in Japanese hepatitis C. 相似文献
73.
Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts. 总被引:20,自引:13,他引:20 下载免费PDF全文
R P Shiu J Pouyssegur I Pastan 《Proceedings of the National Academy of Sciences of the United States of America》1977,74(9):3840-3844
Chick embryo fibroblasts transformed by Rous sarcoma virus have an increased content of two membrane proteins of molecular weights 78,000 and 95,000. The increased content of the 95,000-dalton protein and the principal increase in the content of the 78,000-dalton protein are not an early consequence of cell transformation but instead are secondary to the rapid depletion of glucose from the growth medium of transformed cells. When glucose is maintained at high levels in the growth medium of transformed cells, the synthesis of the 95,000-dalton protein is arrested and that of the 78,000-dalton protein is markedly suppressed. Upon removal of glucose from the growth medium of normal cells, these proteins increase to levels comparable to those of transformed cells. Because the amount of these two proteins is influenced by the presence or absence of glucose, we suggest they be referred to as "glucose-regulated proteins." GRP-78 and GRP-95. These proteins may have an important role in regulating the utilization of glucose in cultured cells. 相似文献
74.
Antibodies to the preS2 antigen (anti-preS2) of the hepatitis B virus (HBV), including IgA, IgM and IgG classes, were observed in patients with acute and persistent HBV infection. In acute HBV infection, rapid and marked serum IgM and IgA anti-preS2 responses were observed. Antibodies reached a peak of serum activity at about 1-2 months after the onset of clinical symptoms, and both antibodies disappeared from serum at 4 months after. IgG anti-preS2 was detected in the early phase of the illness, then the level of IgG anti-preS2 gradually rose during the recovery phase. In persistent HBV infection, IgG and IgM anti-preS2 were detected in sera where the preS2 antigen was present, and IgM anti-preS2 was significantly higher (p less than 0.05) in HBeAg-positive than in HBeAg-negative patients. These results indicate that an adequate humoral immune response to the preS2 antigen is induced during acute and persistent HBV infection. 相似文献
75.
Terukatsu Arima M.D. Chisato Mori Akihisa Takamizawa Hiroyuki Shimomura Takao Tsuji 《Journal of gastroenterology》1990,25(2):218-222
A random primed lambda gtll-cDNA library was constructed from donors plasma presumably infected by blood-borne non-A, non-B
hepatitis (hepatitis C:HC) agent and immunoscreened with serum pooled from patients with acute or chronic HC. Twelve lambda
gtll-cDNA clones encoding antigens associated with HC infection in Japan as well as in the USA were isolated. Of these one
clone consisting of 114 nucleotides and showing a discrete band on an immunoblot analysis, was extensively studied. The clone
is not derived from the host DNA encoding one polypeptide specific and highly sensitive for serum from patients with HC and
has no homology to the nucleotide sequences of known human viruses including hepatitis A, B and D viruses, Ebstein-Barr virus,
coxsackievirus, immunodeficiency virus type 1 or Japanese encephalitis virus. These results suggest that this clone is derived
from the genome of HC agent. 相似文献
76.
Shunsuke Koseki Takamasa Noda Satoshi Yokoyama Yoshihiko Kunisato Daisuke Ito Haruna Suyama Taro Matsuda Yuji Sugimura Naoko Ishihara Yu Shimizu Kanako Nakazawa Sumiko Yoshida Kunimasa Arima Shin-ichi Suzuki 《Journal of affective disorders》2013
Background
Recently, neurobiological studies of the cognitive model of depression have become vastly more important, and a growing number of such studies are being reported. However, the relationship between the proportion of positive and negative automatic thought and activity in the prefrontal and temporal cortices has not yet been explored. We examined the relationship between brain activity and the proportion of positive and negative automatic thought in patients with major depressive disorder (MDD), using multi-channel near-infrared spectroscopy (NIRS).Methods
We recruited 75 individuals with MDD (36 females; mean age=39.23±12.49). They completed the Hamilton Rating Scale for Depression, Automatic Thoughts Questionnaire-Revised, Japanese version of the National Adult Reading Test, and the State-Trait Anxiety Inventory. Brain activation was measured by 52-channel NIRS.Results
We found that activation in the vicinity of the right superior temporal gyrus is related to a deviation to negative of the proportion of positive and negative thoughts in individuals with MDD. Left dorsolateral prefrontal cortex activity was higher in the group with comparatively frequent positive thought.Limitations
Our participants were patients taking antidepressant medication, which is known to influence brain activity. Second, the poor spatial resolution of NIRS increases the difficulty of identifying the measurement position.Conclusions
We found that activation of the prefrontal and temporal cortices is related to the proportion of automatic thoughts in the cognitive model of depression. 相似文献77.
The definition of early carcinoma of the esophagus has changed with time on the basis of new data. As from 2007 an early carcinoma is defined as an intramucosal carcinoma with or without metastasis. In the subclassification based on invasion depth, m1 and m2 squamous cell carcinomas have no metastasis and are considered curable by endoscopic resection alone, whereas less than 10% of m3 carcinomas and some 20% of sm1 squamous cell carcinomas have lymph node metastasis. In this article the relationship between various histopathological findings and the incidence of lymph node metastasis is reviewed. The m3 and sm1 superficial squamous cell carcinomas showing 0-I and 0-III types, large tumors over 50 mm in size or those showing vessel permeation have higher incidences of lymph node metastasis. In the field of gastrointestinal surgical pathology pathologists are now expected to not only diagnose the presence or absence of malignancy but also to investigate in detail many of the histological factors related to the prevalence of lymph node metastasis. 相似文献
78.
79.
Frederick Aardema Adam S. Radomsky Richard Moulding Shiu F. Wong Lysandre Bourguignon Martha Giraldo-O'Meara 《Clinical psychology & psychotherapy》2021,28(5):1160-1180
In recent years, cognitive-behavioural models of OCD have increasingly recognized the potential role of feared possible selves in the development and maintenance of OCD, while simultaneously re-examining factors that have historically been linked to self-perceptions in OCD. The current article describes the development and validation of a multidimensional version of the Fear of Self Questionnaire (FSQ-EV) in a non-clinical (N = 626) and clinical OCD sample (N = 79). Principal component analyses in the non-clinical sample revealed three conceptually and factorially distinct components revolving around a feared corrupted possible self, a feared culpable possible self and a feared malformed possible self. The questionnaire showed a strong internal inconsistency, and good divergent and convergent validity, including strong relationships to obsessional symptoms. In particular, the corrupted feared self predicted OCD symptoms independently from depression and other related self-constructs and obsessive beliefs, while also strongly interacting with importance and control of thoughts in the prediction of almost all specific symptoms of OCD. Results are consistent with the notion that self-constructs can be conceptually and empirically distinguished from obsessive beliefs and appraisals with significant potential to improve our understanding of OCD and related disorders. 相似文献
80.