全文获取类型
收费全文 | 5867篇 |
免费 | 331篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 108篇 |
妇产科学 | 64篇 |
基础医学 | 605篇 |
口腔科学 | 154篇 |
临床医学 | 432篇 |
内科学 | 1649篇 |
皮肤病学 | 78篇 |
神经病学 | 346篇 |
特种医学 | 261篇 |
外科学 | 1144篇 |
综合类 | 29篇 |
预防医学 | 187篇 |
眼科学 | 36篇 |
药学 | 386篇 |
中国医学 | 15篇 |
肿瘤学 | 700篇 |
出版年
2023年 | 62篇 |
2022年 | 94篇 |
2021年 | 232篇 |
2020年 | 112篇 |
2019年 | 147篇 |
2018年 | 177篇 |
2017年 | 138篇 |
2016年 | 169篇 |
2015年 | 168篇 |
2014年 | 262篇 |
2013年 | 272篇 |
2012年 | 445篇 |
2011年 | 494篇 |
2010年 | 275篇 |
2009年 | 204篇 |
2008年 | 350篇 |
2007年 | 337篇 |
2006年 | 352篇 |
2005年 | 323篇 |
2004年 | 296篇 |
2003年 | 287篇 |
2002年 | 268篇 |
2001年 | 56篇 |
2000年 | 58篇 |
1999年 | 65篇 |
1998年 | 63篇 |
1997年 | 53篇 |
1996年 | 40篇 |
1995年 | 39篇 |
1994年 | 43篇 |
1993年 | 25篇 |
1992年 | 37篇 |
1991年 | 30篇 |
1990年 | 41篇 |
1989年 | 31篇 |
1988年 | 21篇 |
1987年 | 19篇 |
1986年 | 14篇 |
1985年 | 17篇 |
1984年 | 15篇 |
1983年 | 12篇 |
1981年 | 11篇 |
1978年 | 6篇 |
1975年 | 8篇 |
1974年 | 8篇 |
1973年 | 6篇 |
1971年 | 7篇 |
1970年 | 6篇 |
1968年 | 5篇 |
1966年 | 6篇 |
排序方式: 共有6240条查询结果,搜索用时 15 毫秒
991.
Kazuaki Kuwabara Shinya Matsuda Kiyohide Fushimi Koichi B. Ishikawa Hiromasa Horiguchi Kenshi Hayashida Kenji Fujimori 《The International journal of health planning and management》2011,26(3):e138-e150
Case‐mix classification has made it possible to analyze acute care delivery case volumes and resources. Data arising from observed differences have a role in planning health policy. Aggregated length of hospital stay (LOS) and total charges (TC) as measures of resource use were calculated from 34 case‐mix groups at 469 hospitals (1 721 274 eligible patients). The difference between mean resource use of all hospitals and the mean resource use of each hospital was subdivided into three components: amount of variation attributable to hospital practice behavior (efficiency); amount attributable to hospital case‐mix (complexity); and amount attributable to the interaction. Hospital characteristics were teaching status (academic or community), ownership, disease coverage, patients, and hospital volume. Multivariate analysis was employed to determine the impact of hospital characteristics on efficiency. Mean LOS and TC were greater for academic than community hospitals. Academic hospitals were least associated with LOS and TC efficiency. Low disease coverage was a predictor of TC efficiency while low patient volume was a predictor of unnecessarily long hospital stays. There was an inverse correlation between complexity and efficiency for both LOS and TC. Policy makers should acknowledge that differentiation of hospital function needs careful consideration when measuring efficiency. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
992.
Hosaka T Nii Y Tomotake H Ito T Tamanaha A Yamasaka Y Sasaga S Edazawa K Tsutsumi R Shuto E Okahisa N Iwata S Sakai T 《Journal of nutritional science and vitaminology》2011,57(6):441-445
Buckwheat has been shown to have various health benefits such as reduction of hypertension and improvement of hypercholesterolemia; however, its effect on diabetes has not been fully elucidated. In this study, buckwheat bran extracts (BBE) inhibited sucrase activity in vitro more effectively than buckwheat. Balb/c mice pretreated with BBE showed dose-dependent reductions of blood glucose, greater than those observed with control mice, within 60 min following oral sucrose administration. Blood glucose levels in mice pretreated with buckwheat extracts were also significantly lower compared to those in control mice within 30 min following oral administration of sucrose. However, rutin, one of the abundant polyphenols of BBE, did not lower blood glucose level. Our data indicate that components of BBE other than rutin have inhibitory activity against sucrase in vivo. These results suggest that BBE could have beneficial effects on diabetes. 相似文献
993.
994.
Tomoya Hirota Takeshi Suzuki Hiroshi Ogishima Shinya Hagiwara Hiroshi Ebe Hiroyuki Takahashi 《Modern rheumatology / the Japan Rheumatism Association》2016,26(1):29-35
Objectives. To compare MRI findings in rheumatoid arthritis (RA) patients treated with biologic disease-modifying anti-rheumatic drugs (DMARDs).Methods. The study subjects were 43 RA patients treated with biologic DMARDs (13 with infliximab, 15 with tocilizumab, and 15 with abatacept). They were evaluated using Simplified Disease Activity Index (SDAI) and low-field extremity MRI at baseline, and at 24 weeks and 52 weeks of treatment.Results. Synovitis scores were significantly lower by 24 weeks in all groups, compared with baseline (P < 0.05). Significant improvement in bone marrow edema (BME) scores were noted from baseline to 24 weeks in infliximab and abatacept groups (P < 0.05), but from 24 weeks to 52 weeks in tocilizumab group (P < 0.01). No significant change was found in erosion score. The synovitis score at baseline correlated significantly with SDAI at 24 weeks (P < 0.05), and the score at 24 weeks correlated significantly with SDAI at 52 weeks (P < 0.05).Conclusions. The results suggest that the inflammatory improvement by infliximab and abatacept may express earlier than those by tocilizumab, despite similar improvement in SDAI. MRI-detected synovitis could be a useful predictor of SDAI at 24 weeks of treatment. The MRI remains the best tool to detect and assess the effects of biologic DMARDs in RA. 相似文献
995.
Eo Toriyama Tomoko Hata Kenichi Yokota Masahiko Chiwata Rena Kamijo Miki Hashimoto Masataka Taguchi Makiko Horai Masatoshi Matsuo Emi Matsuo Yumi Takasaki Yasuhisa Kawaguchi Hidehiro Itonaga Shinya Sato Koji Ando Yasushi Sawayama Jun Taguchi Yoshitaka Imaizumi Hideki Tsushima Tatsuro Jo Shinichiro Yoshida Yukiyoshi Moriuchi Yasushi Miyazaki 《Cancer science》2020,111(12):4490
The efficacy of azacitidine (AZA) on survival of lower risk (LR) ‐ myelodysplastic syndromes (MDS) is controversial. To address this issue, we retrospectively evaluated the long‐term survival benefit of AZA for patients with LR‐MDS defined by International Prognostic Scoring System (IPSS). Using data from 489 patients with LR‐MDS in Nagasaki, hematologic responses according to International Working Group 2006 and overall survival (OS) were compared among patients that received best supportive care (BSC), immunosuppressive therapy (IST), erythropoiesis‐stimulating agents (ESA), and AZA. Patients treated with AZA showed complete remission (CR) rate at 11.3%, marrow CR at 1.9%, and any hematologic improvement at 34.0%, with transfusion independence (TI) of red blood cells in 27.3% of patients. and platelet in 20% of patients, respectively. Median OS for patients received IST, ESA, BSC, and AZA (not reached, 91 months, 58 months, and 29 months, respectively) differed significantly (P < .001). Infection‐related severe adverse events were observed in more than 20% of patients treated with AZA. Multivariate analysis showed age, sex, IPSS score at diagnosis, and transfusion dependence were significant for OS, but AZA treatment was not, which maintained even response to AZA, and IPSS risk status at AZA administration was added as factors. We could not find significant survival benefit of AZA treatment for LR‐MDS patients. 相似文献
996.
997.
998.
999.
Kenshi Hayashida Genki Murakami Shinya Matsuda Kiyohide Fushimi 《Journal of epidemiology / Japan Epidemiological Association》2021,31(1):1
DPC, which is an acronym for “Diagnosis Procedure Combination,” is a patient classification method developed in Japan for inpatients in the acute phase of illness. It was developed as a measuring tool intended to make acute inpatient care transparent, aiming at standardization of Japanese medical care, as well as evaluation and improvement of its quality. Subsequently, this classification method came to be used in the Japanese medical service reimbursement system for acute inpatient care and appropriate allocation of medical resources. Furthermore, it has recently contributed to the development and maintenance of an appropriate medical care provision system at a regional level, which is accomplished based on DPC data used for patient classification. In this paper, we first provide an overview of DPC. Next, we will look back at over 15 years of DPC history; in particular, we will explore how DPC has been refined to become an appropriate medical service reimbursement system. Finally, we will introduce an outline of DPC-related research, starting with research using DPC data.Key words: Diagnosis Procedure Combination (DPC), DPC-based Per-Diem Payment System (DPC/PDPS), patient classification system, health policy, Japan 相似文献
1000.
Shinya Iwase Taka-aki Nakada Noriyuki Hattori Waka Takahashi Nozomi Takahashi Tuerxun Aizimu Masahiro Yoshida Toshio Morizane Shigeto Oda 《The American journal of emergency medicine》2019,37(2):260-265