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AS Tirelli G Paterlini L Ghio A Edefonti BM Assael A Bettinelli G Cavanna F Sereni 《Acta paediatrica (Oslo, Norway : 1992)》1993,82(5):463-468
Little data have been published on tubular renal function during cyclosporin A treatment in children without transplants. We studied 12 young subjects (mean age 10 years) with steroid-responsive idiopathic nephrotic syndrome and with signs of steroid toxicity. After achieving remission with prednisone 60 mg/m2 , 8 children started cyclosporin A therapy (6 mg/kg/day) (group A) and 4 children were given cyclophosphamide 2.5 mg/kg/day (group B). The latter were considered as controls together with 10 other children with idiopathic nephrotic syndrome in complete remission and off therapy (group C). We monitored creatinine clearance and tubular handling of β2 -microglobulin, sodium, phosphorus and uric acid for one year. Cyclosporin A induced a decrease in creatinine clearance with a decrease in fractional excretion of β2 -microglobulin; sodium excretion was similar in the two treated groups and a transient decrease in fractional excretion of uric acid was seen only in patients receiving cyclosporin A. Both groups showed an increased renal threshold phosphate concentration. Our results suggest that in children, cyclosporin A therapy induces a decrease in glomerular filtration rate associated with increased reabsorption activity of proximal tubular cells. 相似文献
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Clinical Exome Gene Panel Analysis of a Cohort of Urothelial Bladder Cancer Patients from Sri Lanka
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Ajith MalalasekeraNilaksha NeththikumaraPraveenan SomasundaramSajeewani PathiranaChathumadavi EdiriweeraDileepa EdiriweeraSerozsha AS GoonewardenaNeville D PereraAnuruddha AbeygunasekaraRohan W JayasekaraKalum WettasingheM Dilani S LokuhettyVajira H W Dissanayeke 《Asian Pacific journal of cancer prevention》2023,24(5):1533-1542
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Male andropause, male climacteric or viropause is a condition in which men suffer from complex symptomatology due to low androgen level with aging. After the age of 40 years testosterone level starts declining and andropause corresponds to the age at which a pathogenic threshold is reached. This review summarizes the etiology, consequences, screening, diagnosis, monitoring of androgen deficiency in aging male (ADAM). The pros and cons of testosterone replacement therapy (TRT) in elderly male have been discussed. Currently oral, transdermal, transbuccal, intramuscular, and subcutaneous implants are available for clinical use. The choice is made by physicians based on therapeutic indication and patient preferences. 相似文献
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Thomas M. Gill MD Joanne M. McGloin MDiv MS MBA Amy Shelton MPH Luann M. Bianco BA Eleni A. Skokos BS MS Nancy K. Latham PhD PT David A. Ganz MD PhD Linda V. Nyquist PhD Robert B. Wallace MD MSc Martha B. Carnie AS Patricia C. Dykes RN PhD MA Lori A. Goehring BA Margaret Doyle MPH Peter A. Charpentier MPH Erich J. Greene PhD Katy L. Araujo MPH 《Journal of the American Geriatrics Society》2020,68(6):1242-1249
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V Schmidt CS Sikasunge E Odongo-Aginya C Simukoko G Mwanjali S Alarakol E Ovuga W Matuja C Kihamia T L?scher AS Winkler G Bretzel 《African health sciences》2015,15(1):58-67
BackgroundTaenia solium metacestodes/cysts obtained from pig carcasses constitute a primary source for diagnostic tools used for the detection of human cysticercosis. Data on T. solium cyst preparation in Africa is still scarce but required to establish independent reference laboratories.ObjectivesThe aim of the present study is a) to present the likely yield of T. solium cyst material by the use of two different preparation methods in the field and b) to investigate its suitability for immunodiagnosis of human cysticercosis.MethodsIn Zambia, Uganda and Tanzania 670 pigs were screened for T. solium infection. Cysts were prepared by ‘shaking method’ and ‘washing method’. Generated crude antigens were applied in a standard western blot assay.Results46 out of 670 pigs (6.9%) were found positive for T. solium (Zambia: 12/367, 3.3%; Uganda: 11/217, 5.1%; Tanzania 23/86, 26.7%). Mean values of 77.7 ml whole cysts, 61.8 ml scolices/membranes and 10.9 ml cyst fluid were obtained per pig. Suitability of collected material for the use as crude antigen and molecular diagnostic techniques was demonstrated.ConclusionThis study clearly shows that T. solium cyst preparation in African settings by simple field methods constitutes an effective way to obtain high quality material as source for diagnostic tools and research purposes. 相似文献