全文获取类型
收费全文 | 1173篇 |
免费 | 37篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 61篇 |
儿科学 | 146篇 |
妇产科学 | 67篇 |
基础医学 | 92篇 |
口腔科学 | 110篇 |
临床医学 | 87篇 |
内科学 | 242篇 |
皮肤病学 | 27篇 |
神经病学 | 48篇 |
特种医学 | 47篇 |
外科学 | 128篇 |
综合类 | 23篇 |
预防医学 | 45篇 |
眼科学 | 24篇 |
药学 | 37篇 |
中国医学 | 2篇 |
肿瘤学 | 29篇 |
出版年
2024年 | 2篇 |
2023年 | 12篇 |
2022年 | 10篇 |
2021年 | 38篇 |
2020年 | 14篇 |
2019年 | 19篇 |
2018年 | 23篇 |
2017年 | 22篇 |
2016年 | 30篇 |
2015年 | 38篇 |
2014年 | 52篇 |
2013年 | 94篇 |
2012年 | 99篇 |
2011年 | 97篇 |
2010年 | 51篇 |
2009年 | 51篇 |
2008年 | 73篇 |
2007年 | 72篇 |
2006年 | 96篇 |
2005年 | 83篇 |
2004年 | 73篇 |
2003年 | 66篇 |
2002年 | 59篇 |
2001年 | 11篇 |
2000年 | 4篇 |
1999年 | 5篇 |
1998年 | 7篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
排序方式: 共有1215条查询结果,搜索用时 15 毫秒
41.
Sema Büğüşan Aysu Kahraman Bülent Elbasan Akmer Mutlu 《Disability and health journal》2018,11(2):287-292
Background
It is important to determine the quality of life (QoL) and level of participation in children with Cerebral Palsy (CP). Previous research has used reports from adolescents or caregivers, but there is no evidence that caregivers' reports accurately reflect the experiences of the adolescents they are interested in.Objective/Hypothesis
The aim of this study was to investigate whether a difference was present in the views of the adolescents and their caregivers regarding the participation and the quality of life of adolescents with CP, and to reveal the parameters creating such differences.Methods
The participation levels and QoL of the adolescents were evaluated separately by the caregiver and the adolescent using the Pediatric Outcomes Data Collection Instrument (PODCI).Results
A statistically significant difference was found in terms of caregivers and adolescents' scores of PODCI upper extremity (Z = ?2,560, p = 0,008), transfer&basic mobility (Z = ?3,839, p = 0,000), sports/physical functioning (Z = ?3,103, p = 0,002), happiness (Z = ?2,420, p = 0,016) and global functioning (Z = ?3,639, p = 0,001). The children's scores were statistically significantly higher than caregivers'. It was found that there was a poor consistence in terms of caregivers and adolescents' scores of upper extremity (ICC = 0,373, p = 0,012), transfer/basic mobility (ICC = 0,289, p = 0,016), sport/physical functioning (ICC = 0,359, p = 0,009); moderate consistence in terms of those of global functioning (ICC = 0,421, p = 0,003).Conclusion
It was determined that caregivers and children's answers were not compatible with one another especially in terms of subjective assessments such as happiness and pain, which suggests that the consideration of caregivers or children in the assessment of subjective situations will change the results. 相似文献42.
Brain Imaging and Behavior - In this study, it was aimed to evaluate the dorsal striatum nuclei of patients diagnosed with Functional Neurological Disorder by texture analysis method from magnetic... 相似文献
43.
Purpose: To evaluate the results of diode laser photocoagulation (DLP) of the retina posterior to the ridge in eyes with severe Zone II, Stage 3+ threshold retinopathy of prematurity (ROP).Method: DLP was applied posterior to the fibrovascular ridge for advanced Zone II, Stage 3+ threshold ROP patients, either as the primary treatment combined with DLP of the avascular retina (group 1), or as a secondary treatment in eyes that had previously undergone DLP of the avascular retina (group 2). Statistical analysis was performed using SPSS software trail version 16.0. Values are presented as mean?±?SD.Results: A total of 50 eyes of 29 premature infants were treated (14 [48%] male, 15 [52%] female). The mean gestational age was 29.5?±?2.2 weeks (range: 26–34 weeks). The mean birth weight was 1259 0.72?±?409.15?g (range: 500–2050?g). The mean gestational age for DLP of the avascular region anterior to the ridge and DLP posterior to the ridge was 37?±?3 weeks and 38?±?3 weeks, respectively. The mean follow-up was 26?±?5 weeks (18–38 weeks). In 48 eyes, the tractional fibrovascular ridge had regressed. Transient retinal hemorrhage was the most common complication. Three eyes exhibited optic-disc dragging; two eyes progressed to Stage 4a ROP; two eyes presented with macular traction, without any detachment; and one eye developed a vitreous hemorrhage, which resolved spontaneously. There were no statistically significant differences between complicated and uncomplicated eyes regarding gestational age, birth weight and applied laser spot numbers (p?>?0.05 for all, Mann–Whitney U test).Conclusion: DLP, posterior to the ridge as an additive treatment in the management of severe Zone II, Stage 3+ threshold ROP patients, is safe and effective; this approach could be used as either the primary treatment, or as the follow-up to failed laser treatment of the avascular retina to halt the progression of the disease. 相似文献
44.
Mehmet Saglam Alpdogan Kantarci Niyazi Dundar Sema S. Hakki 《Lasers in medical science》2014,29(1):37-46
The aim of this randomized, parallel, controlled clinical trial was to examine the clinical and biochemical efficacy of diode laser as an adjunct to scaling and root planing (SRP). Thirty chronic periodontitis patients were randomly assigned into two groups to receive SRP alone (control) or SRP followed by diode laser (test). Plaque index, gingival index, bleeding on probing, probing depth, and clinical attachment level were measured at baseline and at 1, 3, and 6 months after treatment. The gingival crevicular fluid levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-8 (MMP-8) and tissue inhibitor matrix metalloproteinase-1 (TIMP-1) were analyzed by enzyme-linked immunosorbent assay. Test group showed significantly a better outcome compared to the control group in full-mouth clinical parameters. MMP-1, MMP-8, and TIMP-1 showed significant differences between groups after treatment compared to baseline (p?<?0.05). The total amount of IL-1β, IL-6, MMP-1, MMP-8, and TIMP-1 decreased (p?<?0.05) and IL-8 increased after treatment in both test and control groups (p?<?0.05). Diode laser provided significant improvements in clinical parameters and MMP-8 was significantly impacted by the adjunctive laser treatment at first month providing an insight to how lasers can enhance the outcomes of the nonsurgical periodontal therapy. 相似文献
45.
Yucel Erbilgin Ozden Hatirnaz Ng Ismail Can Sinem Firtina Fulya Kucukcankurt Serap Karaman Zeynep Karakas Tulin Tiraje Celkan Emine Zengin Sema Aylan Gelen Gul Nihal Ozdemir Yildiz Yildirmak Omer Dogru Turkan Tansel Khusan Khodzhaev Ozlem Toluk Ugur Ozbek Muge Sayitoglu 《International journal of laboratory hematology》2021,43(5):1093-1103
46.
47.
Asude Durmaz Tahir Atik Hüseyin Onay Ebru Erbaş Canda Sema Kalkan Uçar Fikret Bademkıran Mahmut Çoker Özgür Çoğulu Ferda Özkınay 《Metabolic brain disease》2014,29(3):809-812
X linked adrenoleukodystrophy (X-ALD) is a neurodegenerative disease characterized by progressive demyelination of the central nervous system, adrenocortical insufficiency and elevated levels of very long chain fatty acids (VLCFAs). It is caused by mutations in ABCD1 gene located at Xq28. More than 1,300 mutations have been identified to date which is unique to each patient. In this study we report the mutational analysis of 2 X-ALD patients (1 male and 1 female) showing variable clinical spectrum. The mutation analysis of the female patient revealed IVS5-6delC (c.1489-6delC) and p. P543L variations in compound heterozygous state. The male patient was found to be hemizygous for a novel mutation, p. R104P. In conclusion, while defining a novel mutation, the cases presented herein may contribute to the mutation and clinical spectrum of X-ALD. 相似文献
48.
Sema?Sezgin GoksuEmail author Seyda?Gunduz Dilek?Unal Mukremin?Uysal Deniz?Arslan Ali?M?Tatl? Hakan?Bozcuk Mustafa?Ozdogan Hasan?S?Coskun 《BMC palliative care》2014,13(1):51
Background
An increasing number of patients receive palliative chemotherapy near the end of life. The aim of this study is to evaluate the aggressiveness of chemotherapy in Turkish individuals near the end of life.Methods
Patients diagnosed with solid tumors and died from 2010 to 2011 in the medical oncology department of Akdeniz University were included in the study. Data about the diagnosis, treatment details and imaging procedures were collected.Results
Three hundred and seventy-three people with stage IV solid tumors died from 2010 to 2011 in our clinic. Eighty-nine patients (23.9%) patients underwent chemotherapy in the last month of life while 39 patients (10.5%) received chemotherapy in the last 14 days. The probability of undergoing chemotherapy in the last month of life was influenced by: age, ‘newly diagnosed’ patients, and performance status. There was no significant association of chemotherapy in the last month of life with gender and tumor type. Having a PET-CT scan did not alter the chemotherapy decision.Conclusion
In conclusion, chemotherapy used in the last month of life in a tertiary care center of Turkey is high. Increasing quality of life should be a priority near the end of life and physicians should consider ceasing chemotherapy and direct the patient to early palliative care.49.
Ezgi Kran Tac Miray Karakoyun Nihal
zdemir Karada Hamiyet Hekimci
zdemir Deniz Ylmaz Karapnar Can Karaca Funda etin Sema Aydodu 《The Turkish journal of gastroenterology》2021,32(3):313
Background: Hepatitis-associated aplastic anemia (HAAA) is a rare complication that presented with bone marrow failure after acute hepatitis. HAAA usually occurs in adolescent men within 1-6 months following hepatitis. Most of HAAA’s etiology has non-A-E viral hepatitis.Methods: Our retrospective study included patients with acute fulminant hepatitis who had been treated in Ege University Pediatric Gastroenterology, Hepatology and Nutrition Department and İzmir Kent Hospital Clinical, laboratory, and epidemiological data of the patients were collected from the files.Results: In this study, 499 children underwent liver transplantation (LT) in two pediatric transplantation centers. Sixty-eight (13.6%) out of 499 patients, underwent liver transplantation due to fulminant hepatic failure (FHF). Therefore, a total of 64 patients (34 girls, 30 boys) with a diagnosis of FHF have included in the study. Thirty-two (50.0%) of 64 FHF were due to non-A-E hepatitis and 4 out of the 64 patients (6.2%) with FHF developed HAAA. All of the patients received prednisolone as immunosuppression treatment after LT. Three patients were also given Tacrolimus and 1 received an additional mycophenolate mofetil. One of the patients was given prednisolone and cyclosporine treatment without tacrolimus. Bone marrow transplantation was performed in 1 patient (25.0%). Two of the patients received immunosuppressive treatment including rabbit-derived anti-thymocyte globulin, cyclosporine, and initially prednisolone.Conclusion: In children who underwent liver transplantation for non-A-E FHF are at high risk to develop aplastic anemia. The clinicians should be alert after orthotropic liver transplantation patient could develop aplastic anemia and early treatment with immunosuppressive therapies result in a more successful outcome. 相似文献
50.
Vatansev C Belviranli M Aksoy F Tuncer S Sahin M Karahan O 《Surgical laparoscopy, endoscopy & percutaneous techniques》2002,12(4):243-246
Although tension-free techniques of hernia repair using synthetic meshes have yielded encouraging results, the best method of inguinal hernia repair is still unclear. The aim of this study was to compare the responses of inflammatory mediators and postoperative pain relief following laparoscopic total extraperitoneal (TEP) hernioplasty, open tension-free mesh hernioplasty (Lichtenstein), posterior preperitoneal mesh hernioplasty (Nyhus procedure), and Bassini procedure. Patients with primary inguinal hernia were randomized in the operating room to undergo one of these repair techniques. Group I comprised 24 patients treated by Lichtenstein procedure; Group II comprised 21 patients treated by Nyhus procedure; Group III comprised 19 patients treated by Bassini procedure; and Group IV comprised 20 patients treated by laparoscopic TEP mesh hernioplasty. Postoperative pain levels following hernia repair were compared by measuring the use of patient-controlled analgesia (PCA) during the 24 hours after surgery. Serum samples withdrawn before surgery and 48 hours after surgery were assayed for C-reactive protein (CRP) content. Patient characteristics, operating time, and operative and early complications were noted. Serum CRP levels rose markedly following Nyhus (184.5 +/- 41.6 mg/L), Lichtenstein (138.4 +/- 72.5 mg/L), and Bassini repair (137.2 +/- 55.9 mg/L) compared with that of patients who underwent TEP mesh hernioplasty (55.5 +/- 41.2 mg/L). There were also significant differences in the postoperative need for analgesics via PCA among patients undergoing Nyhus (382.9 +/- 189.1 mg), Bassini (303.2 +/- 173.7 mg), and Lichtenstein (253.9 +/- 129.3) procedures compared with 196.6 +/- 148.8 mg for the TEP mesh hernioplasty group. Patients in the Lichtenstein group also had significantly less need of analgesics than those in the Nyhus and Bassini groups. In conclusion, TEP mesh hernioplasty is less traumatic and yields less postoperative pain than the Nyhus, Lichtenstein, and Bassini procedures. 相似文献