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排序方式: 共有493条查询结果,搜索用时 15 毫秒
91.
醋氨酚缓释包衣颗粒研究 总被引:1,自引:0,他引:1
包衣颗粒体外溶出试验证明在释放量达66%以前为零级恒速释放,此后释放速率降低为非零级释放。颗粒在室温下密闭贮存21个月后,释放速率增快,但仍为零级释放,也是在释放量达66%以后转变为非零级释放。用尿药排泄速率法研究了包衣颗粒的体内动力学并与常规片剂作比较,并测出两者的消除速率常数。常规片剂所得药物t 1/2=3.21h,而包衣颗粒剂所得半衰期约延长2.5倍。通过吸收百分率与体外溶出百分率在不同时间下数值的比较得到线性关系,相关系数r=0.9886。说明体外溶出数据可以作为控制吸收率的依据。按一级吸收一室模型公式计算了一定剂量下的血药浓度,在13h以内血药浓度都在治疗浓度范围(5~20μg/ml)以内。最高浓度为10.5μg/ml,达峰时间为3.27h。本品一次服1.1g可延效12h。 相似文献
92.
Endobronchial metastasis from prostate carcinoma 总被引:1,自引:0,他引:1
Metastasis from the prostate to the lungs is common; however, endobronchial metastasis from the prostate has been reported only twice. We report a patient with endobronchial metastases from the prostate in the absence of bony metastases. Clinical and roentgenographic findings of pulmonary metastases from prostate cancer are described, and therapeutic considerations are discussed. 相似文献
93.
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95.
Liu JM; Chu HC; Chin YH; Chen YM; Hsieh RK; Chiou TJ; Whang-Peng J 《Japanese journal of clinical oncology》1997,27(1):37-41
The aim of this study was to ascertain the prevalence of alternative
medicine consumption in Chinese cancer patients on active conventional
treatment. A cross sectional survey of 100 consecutive advanced cancer
patients admitted to a cancer clinical trial referral unit were personally
interviewed by their assigned oncology research nurse using a specially
designed questionnaire. The results showed that 64% of our patients used
indigenous Chinese medication. In all age groups except the over-70s (P =
0.043), > 50% took such medication, more female (76%) than male (57.6%)
patients (P = 0.323). Patients of all educational levels (P = 0.062) and
religious backgrounds (P = 0.08) consumed alternative medicines. Duration
of alternative medication consumption was less than three months in 50% of
patients, with costs between US$40 and 2000/month for 70% of patients.
Reasons cited for alternative medication consumption was hope that it might
be of some benefit to their well being or disease control, and maybe even
result in a miracle cure. Sources of advice on medication were mostly from
strangers (by word of mouth), family, friends, the media, and infrequently
from qualified professional Chinese doctors. Reasons for discontinuing such
treatment were mostly given as lack of positive effect. In conclusion,
Chinese cancer patients, willingly, rampantly and non-selectively seek out
and consume alternative medications, with almost total ignorance of the
medication consumed, oblivious to any potential side effects, and with
little subjective benefit.
相似文献
96.
97.
Twenty one children with cystic fibrosis were advised to decrease their pancreatic enzyme supplement (PES) dose to less than 10,000 units lipase/kg/day. Mean PES dosage was significantly decreased in 15 patients from 18,380 to 8647 units lipase/kg/day. There were no significant changes in energy or fat intake, but there were significant increases in weight SD score, height SD score, and weight/height ratio. 相似文献
98.
Close mapping of the focal non-epidermolytic palmoplantar keratoderma (PPK) locus associated with oesophageal cancer (TOC) 总被引:1,自引:1,他引:1
Kelsell DP; Risk JM; Leigh IM; Stevens HP; Ellis A; Hennies HC; Reis A; Weissenbach J; Bishop DT; Spurr NK; Field JK 《Human molecular genetics》1996,5(6):857-860
Focal non-epidermolytic palmoplantar keratoderma (PPK or palmoplantar
ectodermal dysplasia type III) is associated with oesophageal cancer in
three families: two large pedigrees located in Liverpool, UK and in the
midwestern American states and one smaller family from Germany. In these
families, the PPK is inherited as autosomal dominant and has a late onset,
usually manifesting between 7 and 8 years of age. The disease is
characterised by thickening of the pressure areas of the soles, but is not
restricted to the feet and also presents with oral leukokeratosis and
follicular hyperkeratosis. The disease locus [previously termed the
"tylosis oesophageal cancer gene' (TOC) locus] has been mapped to
17q23-qter by linkage analysis. This region is located telomeric to the
keratin 16 gene, in which mutations have been identified in focal PPK
families who show no increased cancer risk. We describe the close mapping
of this locus to the interval between AFMb054zf9 and D17S1603 using
haplotype analysis of additional Genethon markers in the region and show
that although the American family is unlikely to be related to either of
the other two, the UK and German pedigrees may share a common descent. This
work provides a basis for positional cloning and candidate gene analysis in
order to identify a gene that may be involved in familial oesophageal
cancer.
相似文献
99.
Catherine R. C. Strong Mark D. Scherz Michael W. Caldwell 《Anatomical record (Hoboken, N.J. : 2007)》2021,304(10):2303-2351
Snakes—a subset of lizards—have traditionally been divided into two major groups based on feeding mechanics: “macrostomy,” involving the ingestion of proportionally large prey items; and “microstomy,” the lack of this ability. “Microstomy”—considered present in scolecophidian and early-diverging alethinophidian snakes—is generally viewed as a symplesiomorphy shared with non-snake lizards. However, this perspective of “microstomy” as plesiomorphic and morphologically homogenous fails to recognize the complexity of this condition and its evolution across “microstomatan” squamates. To challenge this problematic paradigm, we formalize a new framework for conceptualizing and testing the homology of overall character complexes, or “morphotypes,” which underlies our re-assessment of “microstomy.” Using micro-computed tomography (micro-CT) scans, we analyze the morphology of the jaws and suspensorium across purported “microstomatan” squamates (scolecophidians, early-diverging alethinophidians, and non-snake lizards) and demonstrate that key components of the jaw complex are not homologous at the level of primary character state identity across these taxa. Therefore, rather than treating “microstomy” as a uniform condition, we instead propose that non-snake lizards, early-diverging alethinophidians, anomalepidids, leptotyphlopids, and typhlopoids each exhibit a unique and nonhomologous jaw morphotype: “minimal-kinesis microstomy,” “snout-shifting,” “axle-brace maxillary raking,” “mandibular raking,” and “single-axle maxillary raking,” respectively. The lack of synapomorphy among scolecophidians is inconsistent with the notion of scolecophidians representing an ancestral snake condition, and instead reflects a hypothesis of the independent evolution of fossoriality, miniaturization, and “microstomy” in each scolecophidian lineage. We ultimately emphasize that a rigorous approach to comparative anatomy is necessary in constructing evolutionary hypotheses that accurately reflect biological reality. 相似文献
100.
ME Christian HC Davidsonl RH Wiggins G Berges G Cannon G Jackson B Chapman HR Harnsberger 《Journal of digital imaging》2001,14(1):14-17
Several studies have addressed the implications of filmless radiologic imaging on telemedicine, diagnostic ability, and electronic teaching files. However, many publishers still require authors to submit hard-copy images for publication of articles and textbooks. This study compares the quality digital images directly exported from picture archive and communications systems (PACS) to images digitized from radiographic film. The authors evaluated the quality of publication-grade glossy photographs produced from digital radiographic images using 3 different methods: (1) film images digitized using a desktop scanner and then printed, (2) digital images obtained directly from PACS then printed, and (3) digital images obtained from PACS and processed to improve sharpness prior to printing. Twenty images were printed using each of the 3 different methods and rated for quality by 7 radiologists. The results were analyzed for statistically significant differences among the image sets. Subjective evaluations of the filmless images found them to be of equal or better quality than the digitized images. Direct electronic transfer of PACS images reduces the number of steps involved in creating publication-quality images as well as providing the means to produce high-quality radiographic images in a digital environment. 相似文献