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排序方式: 共有1023条查询结果,搜索用时 15 毫秒
91.
92.
The authors examined the associations between coronary artery calcification and a family history of premature coronary heart disease in either first-degree (immediate family) or second-degree (grandparents, aunts, uncles) relatives in 1619 asymptomatic healthy men ages 40-50 years. The prevalence of any coronary artery calcification was 19.3% in participants (n=1102) with no family history, 26.6% in those with a first-degree family history (n=203; 12.5%), 26.5% in those with a second-degree family history (n=215, 13.3%), and 30.3% with both (n=99, 6.1%, p=0.003). After controlling for the Framingham risk score, body mass index, and ethnicity, all categories of family history were significant predictors of coronary artery calcification. The odds ratios for coronary artery calcification associated with a first- (1.49; p=0.026) and second-degree (1.41; p=0.049) family history of coronary heart disease were similar. Clinical coronary risk assessments should broadly include an assessment of premature coronary heart disease in both first- and second-degree relatives. 相似文献
93.
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis 总被引:5,自引:4,他引:5 下载免费PDF全文
Bharti AC Shishodia S Reuben JM Weber D Alexanian R Raj-Vadhan S Estrov Z Talpaz M Aggarwal BB 《Blood》2004,103(8):3175-3184
94.
M. Trent Herdman Natthida Sriboonvorakul Stije J. Leopold Sam Douthwaite Sanjib Mohanty M. Mahtab Uddin Hassan Richard J. Maude Hugh WF Kingston Katherine Plewes Prakaykaew Charunwatthana Kamolrat Silamut Charles J. Woodrow Kesinee Chotinavich Md. Amir Hossain M. Abul Faiz Saroj Mishra Natchanun Leepipatpiboon Nicholas J. White Nicholas PJ Day Joel Tarning Arjen M. Dondorp 《Critical care (London, England)》2015,19(1)
IntroductionSevere falciparum malaria is commonly complicated by metabolic acidosis. Together with lactic acid (LA), other previously unmeasured acids have been implicated in the pathogenesis of falciparum malaria.MethodsIn this prospective study, we characterised organic acids in adults with severe falciparum malaria in India and Bangladesh. Liquid chromatography-mass spectrometry was used to measure organic acids in plasma and urine. Patients were followed until recovery or death.ResultsPatients with severe malaria (n=138), uncomplicated malaria (n=102), sepsis (n=32) and febrile encephalopathy (n=35) were included. Strong ion gap (mean±SD) was elevated in severe malaria (8.2 mEq/L±4.5) and severe sepsis (8.6 mEq/L±7.7) compared with uncomplicated malaria (6.0 mEq/L±5.1) and encephalopathy (6.6 mEq/L±4.7). Compared with uncomplicated malaria, severe malaria was characterised by elevated plasma LA, hydroxyphenyllactic acid (HPLA), α-hydroxybutyric acid and β-hydroxybutyric acid (all P<0.05). In urine, concentrations of methylmalonic, ethylmalonic and α-ketoglutaric acids were also elevated. Multivariate logistic regression showed that plasma HPLA was a strong independent predictor of death (odds ratio [OR] 3.5, 95 % confidence interval [CI] 1.6–7.5, P=0.001), comparable to LA (OR 3.5, 95 % CI 1.5–7.8, P=0.003) (combined area under the receiver operating characteristic curve 0.81).ConclusionsNewly identified acids, in addition to LA, are elevated in patients with severe malaria and are highly predictive of fatal outcome. Further characterisation of their sources and metabolic pathways is now needed.
Electronic supplementary material
The online version of this article (doi:10.1186/s13054-015-1023-5) contains supplementary material, which is available to authorized users. 相似文献95.
Imran Ali Changsheng Peng Iffat Naz Dichu Lin Devendra P. Saroj Mohsin Ali 《RSC advances》2019,9(7):3625
Novel bio-magnetic membrane capsules (BMMCs) were prepared by a simple two-step titration-gel cross-linking method using a polyvinyl alcohol (PVA) and sodium alginate (SA) matrix to control the disintegration of phytogenic magnetic nanoparticles (PMNPs) in an aqueous environment, and their performance was investigated for adsorbing cationic malachite green (MG) dye from water. The prepared BMMCs were characterized by FTIR, powder XRD, SEM, EDX, XPS, VSM and TGA techniques. The findings revealed that the hysteresis loops had an excellent superparamagnetic nature with saturation magnetization values of 11.02 emu g−1. The prepared BMMCs not only controlled the oxidation of PMNPs but also improved the adsorptive performance with respect to MG dye (500 mg g−1 at 298.15 K and pH 6.5) due to the presence of a large amount of hydrophilic functional groups (hydroxyl/–OH and carboxyl/–COOH) on/in the BMMCs. The smooth encapsulation of PMNPs into the PVA–SA matrix established additional hydrogen bonding among polymer molecular chains, with improved stability, and adsorptive performance was maintained over a wide range of pH values (3–12). Importantly, the prepared BMMCs were easily regenerated just by washing with water, and they could be re-utilized for up to four (4) consecutive treatment cycles without observing any apparent dissolution of iron/Fe0 or damage to the morphology. According to the mass balance approach, an estimated amount of 100 mL of treated effluent can be obtained from 160 mL of MG dye solution (25 mg L−1) just by employing a 0.02 g L−1 adsorbent dosage. Finally, a model of BMMCs based on zero-effluent discharge was also proposed for commercial or industrial applications. The prepared BMMCs are greatly needed for improving the water/wastewater treatment process and they can be utilized as an excellent adsorbent to remove cationic pollutants for various environmental applications.Novel bio-magnetic membrane capsules were prepared by a simple two-step titration-gel cross-linking method using a polyvinyl alcohol and sodium alginate matrix to control the disintegration of phytogenic magnetic nanoparticles in aqueous media. 相似文献
96.
Tanaka Y Nishida K Nakamura T Chapagain SK Inoue D Sei K Mori K Sakamoto Y Kazama F 《Journal of water and health》2012,10(1):170-180
Although groundwater is a major water supply source in the Kathmandu Valley of Nepal, it is known that the groundwater has significant microbial contamination exceeding the drinking water quality standard recommended by the World Health Organization (WHO), and that this has been implicated in causing a variety of diseases among people living in the valley. However, little is known about the distribution of pathogenic microbes in the groundwater. Here, we analysed the microbial communities of the six water samples from deep tube wells by using the 16S rRNA gene sequences based culture-independent method. The analysis showed that the groundwater has been contaminated with various types of opportunistic microbes in addition to fecal microbes. Particularly, the clonal sequences related to the opportunistic microbes within the genus Acinetobacter were detected in all samples. As many strains of Acinetobacter are known as multi-drug resistant microbes that are currently spreading in the world, we conducted a molecular-based survey for detection of the gene encoding carbapenem-hydrolysing β-lactamase (bla(oxa-23-like) gene), which is a key enzyme responsible for multi-drug resistance, in the groundwater samples. Nested polymerase chain reaction (PCR) using two specific primer sets for amplifying bla(oxa-23-like) gene indicated that two of six groundwater samples contain multi-drug resistant Acinetobacter. 相似文献
97.
The incidence of restenosis has significantly reduced following introduction of drug-eluting stents. However. complications i.e. subacute thrombosis and aneurysm formation may be higher with these stents. We report a case of giant aneurysm formation following drug-eluting stent implantation. 相似文献
98.
99.
Aneurysms are rare in children. Causes include congenital, traumatic, inflammatory, and infectious etiologies. When and how to best surgically treat arterial aneurysms in a child remain unclear. We present the case of a 3-month-old child with an aneurysm of the left common iliac artery, which was first detected on abdominal ultrasound and was successfully repaired with a cadaveric vein graft. 相似文献
100.
Sabaretnam M Mishra A Chand G Agarwal G Agarwal A Verma AK Mishra SK 《World journal of surgery》2012,36(6):1293-1299