全文获取类型
收费全文 | 612篇 |
免费 | 56篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 14篇 |
妇产科学 | 7篇 |
基础医学 | 82篇 |
口腔科学 | 14篇 |
临床医学 | 55篇 |
内科学 | 172篇 |
皮肤病学 | 9篇 |
神经病学 | 21篇 |
特种医学 | 23篇 |
外科学 | 108篇 |
综合类 | 23篇 |
预防医学 | 33篇 |
眼科学 | 13篇 |
药学 | 65篇 |
中国医学 | 4篇 |
肿瘤学 | 22篇 |
出版年
2023年 | 25篇 |
2022年 | 20篇 |
2021年 | 25篇 |
2020年 | 19篇 |
2019年 | 22篇 |
2018年 | 35篇 |
2017年 | 16篇 |
2016年 | 24篇 |
2015年 | 24篇 |
2014年 | 35篇 |
2013年 | 49篇 |
2012年 | 57篇 |
2011年 | 51篇 |
2010年 | 33篇 |
2009年 | 21篇 |
2008年 | 26篇 |
2007年 | 27篇 |
2006年 | 20篇 |
2005年 | 21篇 |
2004年 | 12篇 |
2003年 | 13篇 |
2002年 | 11篇 |
2001年 | 8篇 |
2000年 | 8篇 |
1999年 | 15篇 |
1998年 | 6篇 |
1997年 | 6篇 |
1996年 | 5篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 6篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1979年 | 1篇 |
1977年 | 2篇 |
1976年 | 1篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1968年 | 1篇 |
1965年 | 1篇 |
1939年 | 1篇 |
排序方式: 共有672条查询结果,搜索用时 555 毫秒
111.
Qura Tul Ain Idrees Nazish Gul Muhammad Amber Fareed Salman Aziz Mian Danish Muzaffar Muhammad Nasir Aqif Anwar Chaudhry Sultan Akhtar Syed Zubairuddin Ahmed Abdul Samad Khan 《Materials》2021,14(24)
This study aimed to modify an EQUIA coat (EC; GC, Japan) by incorporating 1 and 2 wt.% of zinc oxide (ZnO; EC-Z1 and EC-Z2) and titanium dioxide (TiO2; EC-T1 and EC-T2) nanoparticles, whereby structural and phase analyses were assessed using Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD), respectively. Thermogravimetric analysis/differential scanning calorimetry, micro-hardness, and water absorption analyses were conducted, and the microstructure was studied by scanning electron microscopy/energy-dispersive spectroscopy. FTIR spectra showed a reduction in peak heights of amide (1521 cm−1) and carbonyl (1716 cm−1) groups. XRD showed peaks of ZnO (2θ ~ 31.3°, 34.0°, 35.8°, 47.1°, 56.2°, 62.5°, 67.6°, and 68.7°) and TiO2 (2θ ~ 25.3°, 37.8°, 47.9, 54.5°, 62.8°, 69.5°, and 75.1°) corresponding to a hexagonal phase with a wurtzite structure and an anatase phase, respectively. Thermal stability was improved in newly modified materials in comparison to the control group. The sequence of obtained glass transitions was EC-T2 (111 °C), EC-T1 (102 °C), EC-Z2 (98 °C), EC-Z1 (92 °C), and EC-C (90 °C). EC-T2 and EC-T1 showed the highest (43.76 ± 2.78) and lowest (29.58 ± 3.2) micro-hardness values. EC showed the maximum water absorption (1.6%) at day 7 followed by EC-T1 (0.82%) and EC-Z1 (0.61%). These results suggest that EC with ZnO and TiO2 nanoparticles has the potential to be used clinically as a coating material. 相似文献
112.
Xia R Samad TA Btesh J Jiang LH Kays I Stjernborg L Dekker N 《Current topics in medicinal chemistry》2011,11(17):2180-2191
Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel gated by noxious heat, vanilloids and extracellular protons. TRPV1 is acting as an important signal integrator in sensory nociceptors under physiological and pathological conditions including inflammation and neuropathy. Because of its integrative signaling properties in response to inflammatory stimuli, TRPV1 agonists and antagonists are predicted to inhibit the sensation of ongoing or burning pain that is reported by patients suffering from chronic pain, therefore offering an unprecedented advantage in selectively inhibiting painful signaling from where it is initiated. In this article, we firstly summarize recent advances in the understanding of the role of TRPV1 in pain signaling, including a overview of clinical pharmacological trials using TRPV1 agonists and antagonists. Finally, we also present an update on the mechanistic understanding and controlling of hyperthermia caused by TRPU1 antagonists, and provide perspective for future study. 相似文献
113.
S Nazemi H Manaheji J Zaringhalam M Sadeghi A Haghparast 《Pharmacology, biochemistry, and behavior》2012,102(4):520-525
It is confirmed that pharmacological attenuation of glial cells can alleviate neuropathic pain by lowering proinflammatory cytokine expression. The present study tries to confirm that post-injury administration of glia inhibitor, minocycline, can attenuate the neuropathic pain symptoms and improves the efficacy of morphine anti-nociception in chronic constriction injury (CCI). Male Wistar rats (230-270 g) underwent surgery for induction CCI model of neuropathy. For assessment of the thermal hyperalgesia and mechanical allodynia after CCI induction, morphine (2.5, 5, 7.5, 10 and 15 mg/kg; s.c.) and saline were administered on post-operative days (PODs) 0, 6 and 14. Hargreaves and Von-Frey tests were performed before and 30 min after morphine administration, respectively. The results showed significant decrease in antinociceptive effect of morphine on POD 6 compared to POD 0 only at the dose of 5 mg/kg. On the other hand, on POD 14 the antinociceptive effect of morphine (5, 7.5, 10 and 15 mg/kg) significantly decreased in comparison with POD 0. In another set of experiments, animals received minocycline (10, 20 and 40 mg/kg; i.p.) for eight days from POD 6 to 13 and then the antinociceptive effect of single dose of morphine 5 mg/kg was tested on POD 14. Behavioral tests showed that minocycline (40 mg/kg) could effectively attenuate the thermal hyperalgesia and mechanical allodynia on POD 13. Moreover, minocycline (40, 20 mg/kg) improved the anti-hyperalgesic, and minocycline (40 mg/kg) improved the anti-allodynic effects of morphine 5 mg/kg on POD 14. It seems that the reduction of antinociceptive effect of morphine after CCI may be mediated through glia activation. Modulation of glial activity by minocycline can attenuate CCI-induced neuropathic pain. It is also shown that repeated post-injury administration of minocycline improves the antinociceptive effect of morphine in neuropathic pain. 相似文献
114.
115.
116.
117.
118.
Mahmoud Reza Pourkarim Samad Amini-Bavil-Olyaee Philippe Lemey Piet Maes Marc Van Ranst 《Journal of clinical virology》2010,47(4):356-360
BackgroundRecently, several novel hepatitis B virus (HBV) subgenotypes have been introduced that do not meet proper definition of “subgenotypes”. In particular for HBV genotype A, such novel subgenotypes have been reported.ObjectiveTo comprehensively reanalyse all HBV subgenotypes A, and to propose a novel, consistent alternative for HBV classification.Study designAll HBV full-length genome subgenotypes A1–A6 were reanalysed using phylogenetic reconstruction and genetic distance calculation in order to study their evolutionary relationships.ResultsPhylogenetic analysis based on the complete genome sequence of subgenotype A strains revealed four distinct clusters supported by high bootstrap values, whereas only the three groups A1, A2 and A6 could be assigned as subgenotypes. Previously introduced subgenotype A3, “tentative A4” and A5 clustered together in one main branch and were designated as “quasi-subgenotypes”. Also genetic distances failed to classify these three groups as definite subgenotypes. These results advocate for a new classification of HBV genotype A into subgenotype A1, A2, “quasi-subgenotype A3” and A4.ConclusionDetailed phylogenetic analysis of the complete genome sequences demonstrates that some of available HBV genotype A strains may not be considered as definite “subgenotypes”. These strains, which are mainly of African origin, could be considered as “quasi-subgenotypes” which puts them in between the “clade” and “subgenotype” definition. Geographical origin may have a key role in further classification of HBV subgenotypes. 相似文献
119.
120.
Laccourreye O Garabedian EN Samad MA Dubreuil C 《European annals of otorhinolaryngology, head and neck diseases》2012,129(1):38-43
Based on a review of the medical literature (PubMed database, keywords: medical information, informed consent), the authors analyse the main medicolegal aspects concerning the patient information that must be provided in France prior to any invasive diagnostic or therapeutic medical procedures in otorhinolaryngology head and neck surgery, as well as the patient's perception and recall of the information provided, the quality of the information provided and problems encountered in providing this information. In the light of this review, several solutions are recommended to improve this essential phase prior to obtaining the patient's informed consent. 相似文献