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31.
A case of well-differentiated minute hepatocellular carcinoma with extrahepatic metastasis 总被引:1,自引:0,他引:1
SOO RYANG KIM YOSHITAKE HAYASHI TOSHIYUKI MATSUOKA SOK YONG PARK SHIGEYUKI SHINTANI KAZUNORI SASAKI JUN ASANO JUNG HYO KIM KE IH KIM SUSUMU IMOTO HIROSHI ITOH MASATOSHI KUDO 《Journal of gastroenterology and hepatology》1998,13(9):892-896
A rare case of well-differentiated minute hepatocellular carcinoma (HCC) metastasizing to distant sites in a 77-year-old man with hepatitis C virus (HCV)-related cirrhosis is presented. Ultrasonography (US) disclosed a 9 mm hypoechoic lesion in segment seven (S7) of the liver, although computed tomography (CT), magnetic resonance imaging (MRI) and angiography did not reveal any space-occupying lesion. Ultrasound-guided biopsy showed the histological features of well-differentiated HCC. A plain film of the abdomen and CT revealed osteolytic changes in the sacrum and the lumbar vertebra. Ultrasound-guided biopsy of the sacrum revealed well-to-moderately differentiated HCC metastasizing from the liver. Percutaneous ethanol injection therapy (PEIT) effected complete response and completely eliminated the abnormal findings on US. Three months after PEIT, metastasis to the thoracic vertebra was revealed by CT, despite negative α-fetoprotein-mRNA in serum. This is the first report describing a well-differentiated HCC with metastatic potential. Further studies may provide insights into metastasis of well-differentiated HCC. 相似文献
32.
TAKEHIRO INOUE MASAKI OTAKI SUSUMU NAKAMOTO ZHINEI ZANG HIDETAKA OKU 《Pacing and clinical electrophysiology : PACE》2001,24(10):1566-1568
Superior vena cava syndrome due to transvenous pacing leads is an uncommon but potentially life-threatening complication. This case involves a 54-year-old man who developed left innominate vein occlusion due to a pacemaker lead. This complication induced a progressive swelling on the left side of his face, neck, arm, and upper chest. The left innominate vein occlusion was surgically treated using a composite spiral saphenous vein graft. Postoperatively, the patient has received anticoagulation therapy with warfarin to prevent thrombosis and, thereby, the long-term patency of the graft. He has undergone follow-up on a regular outpatient basis without showing any recurrence of clinical symptoms. 相似文献
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34.
The recurrence of interruption of aortic arch (IAA) in siblings is rare. According to previous reports concerning siblings with IAA, all cases were IAA type B according to the classification proposed by Celoria and Patton. In this report we present the first cases of brothers with IAA type A. The type of IAA was confirmed by autopsy findings in the elder brother and by operative findings in the younger brother. The etiology of IAA was unclear. Monogenic inheritance was thought unlikely because congenital heart disease was not recognized in other members of the family. It would seem prudent to separate recurrence risks for IAA type A from IAA type B when genetic counselling is provided, but it must be borne in mind that the recurrence of IAA type A can occur among siblings. 相似文献
35.
TAKESHI UEDA YOKO MIYAKE KOJI IMOTO SHIGENORI HATTORI SUSUMU MIYAKE TORU ISHIZAKI AKIRA YAMADA TAKESHI KURATA TAKAO NAGAI SADAO SUGA YOSHIZO ASANO 《Pediatrics international》1996,38(6):590-595
The distribution of human herpesvirus 6 (HHV-6) and varicella-zoster virus (VZV) was examined in autopsy samples from a fatal case with both virus infections. A 9-month-old boy developed convulsive seizures followed by macular skin rashes, rapidly progressed to brain death, and died 15 days after the onset, when signs of varicella were noted. An isolation of HHV-6 from blood and evaluation of antibody activities to various viral agents including HHV-6 were performed before his death. Postmortem examinations included: (i) isolation of HHV-6 and VZV from tissues or organs; (ii) detection of both virus antigens in tissues or organs by an indirect immunofluorescent assay using monoclonal antibodies to both viruses; (iii) amplification of both viruses and human herpesvirus 7 DNA sequences by a nested polymerase chain reaction assay; and (iv) endonuclease digestion of amplified products of HHV-6 DNA for differentation of variants A and B. Human herpesvirus 6 DNA was detected in peripheral blood mononuclear cells (PBMC) and plasma obtained at the eruptive stage but present only in PBMC 15 days after, indicating the primary infection with HHV-6, although the virus was not isolated from the same blood sample and a significant rise in the antibody titers to HHV-6 was not observed. Both virus antigens and DNA were detected in various tissues or organs obtained at autopsy, but only VZV was isolated from these samples, suggesting disseminated infection with both viruses in an infant. All the amplified products of HHV-6 DNA were variant B. Among the findings for the distribution of virus antigens, it was noteworthy that HHV-6 antigen was demonstrated in the endothelial cells of small vessels in the frontal lobe of the brain. There was no evidence of HHV-7 infection. These data indicate that the primary HHV-6 infection closely followed by the primary VZV infection had the potential hazard of an unexpected and apparently life-threatening event, in which disseminated infections with both viruses were noted in multiple tissues or organs including the brain. 相似文献
36.
Prevention of antibiotic-associated diarrhea in children by Clostridium butyricum MIYAIRI 总被引:4,自引:0,他引:4
HIROMI SEKI MASAAKI SHIOHARA TADAO MATSUMURA NATSUKI MIYAGAWA MAMORU TANAKA ATSUSHI KOMIYAMA SUSUMU KURATA 《Pediatrics international》2003,45(1):86-90
BACKGROUND: Clostridium butyricum MIYAIRI (CBM) is a probiotic bacteria used for anti-diarrheal medicine in Japan. The preventive effect of CBM was investigated for antibiotic-associated diarrhea (AAD) in children. METHODS: One hundred and ten children who suffered from upper respiratory tract infection or gastroenteritis were divided into three groups. Twenty-seven of the patients received only antibiotics, 38 received CBM from the mid point of the antibiotic treatment and 45 concomitantly received CBM from the beginning of the antibiotic treatment. To examine the effects of CBM on AAD, the changes in intestinal flora were investigated. RESULTS: Diarrhea was observed in 59% of the subjects who received only antibiotics, and total fecal anaerobes, especially Bifidobacterium, were remarkably decreased. In contrast, diarrhea in the subjects who received CBM from either the middle or the beginning of the antibiotic therapy was decreased to 5% and 9%, respectively. Concomitant administration of CBM increased anaerobes and prevented the decrease of Bifidobacterium in the subjects who received antibiotics. CONCLUSIONS: Clostridium butyricum MIYAIRI is effective for both the treatment and the prophylaxis of AAD in children, as it normalizes the intestinal flora disturbed by antibiotics. 相似文献
37.
An intriguing relationship between idiopathic mitral valve prolapse (MVP) and cardiomyopathy has been reported in adult cases of MVP. This paper reports a girl with idiopathic MVP, who presented with progressive cardiomegaly and cardiomyopathic findings on cardiac biopsy; right ventricular endomyocardial biopsy at the age of 15 years showed myocardial hypertrophy, disarray, myocardial degeneration, interstitial fibrosis and endocardial thickening. To our knowledge, this is the first case of idiopathic MVP in childhood that has been shown to have positive biopsy findings for cardiomyopathy. 相似文献
38.
TOSHIHIKO NAKANO TOSHIRO FUJIMOTO SUSUMU SHIMOOKI TERUMI FUKUDOME TSUNEHISA UCHIDA TAKAYUKI TSUJI YOSHIO MITSUYAMA HARUO AKIMOTO SHOEI FURUKAWA 《Psychiatry and clinical neurosciences》1996,50(3):157-160
Abstract The nerve growth factor (NGF) content in the hippocampus and frontal cortex of chronic ethanol-treated rats was measured and compared with that of control rats, using a two-site enzyme immunoassay (EIA) system. The different time periods of chronic ethanol treatment caused transient elevation of the NGF content in both the hippocampus and frontal cortex. The NGF content in the hippocampus was significantly elevated in rats undergoing ethanol treatment of 2 weeks and 1 month. Nerve growth factor content of the 1 month treatment was higher than that of the 2 week treatment. However, a 3 month administration of ethanol reduced the NGF content to the control level. The NGF content in the frontal cortex increased significantly in the 2 week administration, but decreased to the control level in the 1 month administration. The increase of NGF may be caused by the proliferation of glial cells or the enhancement of neuronal production of NGF. 相似文献
39.
J. MARECHAL R. WILMOTTE A. KANZAKI D. DHERMY M. GARBARZ C. GALAND T. K. TANG Y. YAWATA J. DELAONAY 《British journal of haematology》1995,90(3):553-556
Summary. AlleleαLELY low-expression allele of erythroid spectrin a-chain. It carries mutations both in exon 40 and intron 45 and is associated with partial skipping of exon 46. Allele αLELY remains asymptomatic by itself. In contrast, it enhances the expression level of deleterious α-alleles occurring in trans , and as such has clinical importance. The aim of this study was to evaluate the incidence of allele Q LBLY m var jous ethnic groups, i.e. Caucasians, African Blacks, Japanese and Chinese. Allele QLELY occurred in all groups investigated with a fairly uniform frequency: 31%, 21%, 20% and 22%, respectively. Mutations in exon 40 and intron 45 appeared linked to one another without exception. Partial skipping of exon 46 or the low-expression feature, whenever they could be assessed, were invariably observed. Allele αLELY appears to be an ancient and stable allele. 相似文献
40.
JUNICHI YOSHIDA SUSUMU YAMASAKI JUNJI YAMAMOTO TOMOO KOSUGE TADATOSHI TAKAYAMA HIROSHI HASEGAWA KENICHI TAKAYASU YUKIO MURAMATSU NORIYUKI MORIYAMA SETSUO HIROHASHI 《Journal of gastroenterology and hepatology》1991,6(4):414-416
A 57 year old Japanese male was incidentally found to have a 7.5 cm diameter hepatic haemangioma. Eleven years later he was operated on because the haemangioma had grown into a 17 cm mass causing upper abdominal fullness. Volumetry on computerized tomograms disclosed that the haemangioma had grown from 123 cm3 to 1343 cm3 in volume. Quantitative documentation on growing hepatic haemangioma has been rare. 相似文献