全文获取类型
收费全文 | 1882篇 |
免费 | 81篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 150篇 |
妇产科学 | 15篇 |
基础医学 | 162篇 |
口腔科学 | 30篇 |
临床医学 | 122篇 |
内科学 | 394篇 |
皮肤病学 | 32篇 |
神经病学 | 99篇 |
特种医学 | 183篇 |
外科学 | 319篇 |
综合类 | 156篇 |
预防医学 | 86篇 |
眼科学 | 9篇 |
药学 | 136篇 |
1篇 | |
中国医学 | 2篇 |
肿瘤学 | 85篇 |
出版年
2023年 | 9篇 |
2021年 | 26篇 |
2020年 | 13篇 |
2019年 | 29篇 |
2018年 | 34篇 |
2017年 | 21篇 |
2016年 | 28篇 |
2015年 | 22篇 |
2014年 | 46篇 |
2013年 | 50篇 |
2012年 | 82篇 |
2011年 | 96篇 |
2010年 | 80篇 |
2009年 | 70篇 |
2008年 | 89篇 |
2007年 | 89篇 |
2006年 | 110篇 |
2005年 | 52篇 |
2004年 | 70篇 |
2003年 | 60篇 |
2002年 | 48篇 |
2001年 | 57篇 |
2000年 | 73篇 |
1999年 | 58篇 |
1998年 | 61篇 |
1997年 | 40篇 |
1996年 | 42篇 |
1995年 | 36篇 |
1994年 | 29篇 |
1993年 | 25篇 |
1992年 | 22篇 |
1991年 | 21篇 |
1990年 | 21篇 |
1989年 | 39篇 |
1988年 | 29篇 |
1987年 | 30篇 |
1986年 | 30篇 |
1985年 | 30篇 |
1984年 | 13篇 |
1983年 | 24篇 |
1982年 | 29篇 |
1981年 | 18篇 |
1980年 | 19篇 |
1979年 | 11篇 |
1978年 | 14篇 |
1977年 | 15篇 |
1976年 | 18篇 |
1975年 | 9篇 |
1974年 | 8篇 |
1973年 | 7篇 |
排序方式: 共有1992条查询结果,搜索用时 296 毫秒
11.
Extensive intraductal component (EIC) has been reported to have a prominent role in local recurrence after treatment of early-stage breast cancer with lumpectomy and irradiation. Pathologic specimens from 250 breasts (245 patients) treated between June 1982 and June 1990 with lumpectomy, immediate (boost) interstitial iridium-192 to 15-20 Gy, and external-beam irradiation to the entire breast to 45-50 Gy were reviewed. EIC was present in 61 breasts. At a median follow-up period of 58 months (range, 14-110 months), there were 10 recurrences in the 250 treated breasts. Of these 10, three were in patients from the group with EIC. The 10-year actuarial recurrence rates in breasts with and without EIC were 9.1% and 5.2%, respectively. The difference between the two rates was not significant. If an immediate boost with interstitial iridium is used in therapy, the influence of EIC on local failure is insignificant. 相似文献
12.
13.
14.
15.
16.
17.
18.
19.
The metallothionein-null phenotype is associated with heightened sensitivity to lead toxicity and an inability to form inclusion bodies 总被引:2,自引:0,他引:2
Qu W Diwan BA Liu J Goyer RA Dawson T Horton JL Cherian MG Waalkes MP 《The American journal of pathology》2002,160(3):1047-1056
Susceptibility to lead toxicity in MT-null mice and cells, lacking the major forms of the metallothionein (MT) gene, was compared to wild-type (WT) mice or cells. Male MT-null and WT mice received lead in the drinking water (0 to 4000 ppm) for 10 to 20 weeks. Lead did not alter body weight in any group. Unlike WT mice, lead-treated MT-null mice showed dose-related nephromegaly. In addition, after lead exposure renal function was significantly diminished in MT-null mice in comparison to WT mice. MT-null mice accumulated less renal lead than WT mice and did not form lead inclusion bodies, which were present in the kidneys of WT mice. In gene array analysis, renal glutathione S-transferases were up-regulated after lead in MT-null mice only. In vitro studies on fibroblast cell lines derived from MT-null and WT mice showed that MT-null cells were much more sensitive to lead cytotoxicity. MT-null cells accumulated less lead and formed no inclusion bodies. The MT-null phenotype seems to preclude lead-induced inclusion body formation and increases lead toxicity at the organ and cellular level despite reducing lead accumulation. This study reveals important roles for MT in chronic lead toxicity, lead accumulation, and inclusion body formation. 相似文献
20.
A. NÆSS 《Scandinavian journal of immunology》1976,5(1-2):165-168
Cerebrospinal fluid (CSF) was allowed to drop straight into Hanks's balanced salt solution. After centrifugation the pellet was resuspended and mixed with sheep erythrocytes. The mixture was further handled as in the E-rosette test with peripheral blood lymphocytes. CSF from 20 individuals were investigated, and rosette-forming cells (RFC) were found in all. Six patients with normal fluid had between 46% and 83% RFC. Four patients with multiple sclerosis had increased numbers of RFC (94%-96%). Low numbers of RFC were found in one patient with cerebellar ataxia and in one of two patients with acute viral meningitis. With this technique RFC can be counted even in normal CSF with a 3-ml sample. 相似文献