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A filter immuno-plaque assay was developed which detects alpha interferon (INF-alpha)-secreting human peripheral blood leucocytes (PBL). Polyclonal anti-IFN-alpha antibodies were fixed to the nitrocellulose membrane bottoms of 96-well Millititer plates, which also contained monolayers of glutaraldehyde-fixed human WISH amnion cells infected by Herpes simplex virus type 1 (HSV). Such cells are potent IFN inducers and during a 16 h cocultivation with PBL, IFN-alpha was absorbed by the membrane-bound polyclonal antibodies around IFN-alpha-secreting cells. This IFN-alpha was detected with murine monoclonal antibodies against IFN-alpha and peroxidase-labelled antibodies against murine immunoglobulin, using diaminobenzidine as substrate. Distinctly stained plaques were seen, the frequency of which gave a minimal estimate of approximately 10 IFN-alpha-producing cells in 10(4) PBL (range in 12 blood donors 2.95-25.1). Fewer plaques than expected were seen at low PBL numbers per culture, one explanation being that cell interactions then limit the IFN-alpha response. The immuno-plaque assay should be useful in further studies of the cellular basis of the IFN-alpha response.  相似文献   
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Uric acid blood and urine studies were performed in 12 patients withlymphomas while on a measured low purine diet before, during and after cytotoxictherapy.

Before treatment, urinary uric acid excretion in these patients was significantlyhigher than in normal subjects, although only 2 patients had clearlyelevated blood uric acid levels. There was no correlation between the estimatedsize of the tumor masses and pretreatment uric acid excretion. The responseto treatment could not have been predicted by measurement of thepretreatment uric acid excretion.

In one patient with extensive tumor infiltration of the kidneys, dangerousrenal failure, preceded by marked hyperuricemia, developed during therapy.Mechanical hemodialysis resulted in clinical improvement and marked reductionin the blood levels of uric acid and urea.

The finding of a large increase in uric acid excretion during the early daysof treatment of a patient with lymphoma is indicative of a responsive tumor.Such data also serve as warning of potential obstructive uric acid nephropathyor uropathy before major increases in serum uric acid appear. Small increasesof uric acid excretion in association with treatment could not be correlatedwith objective clinical response.

Accepted on April 3, 1961  相似文献   
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