全文获取类型
收费全文 | 1629篇 |
免费 | 106篇 |
国内免费 | 20篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 34篇 |
妇产科学 | 207篇 |
基础医学 | 204篇 |
口腔科学 | 42篇 |
临床医学 | 220篇 |
内科学 | 241篇 |
皮肤病学 | 15篇 |
神经病学 | 48篇 |
特种医学 | 133篇 |
外科学 | 241篇 |
综合类 | 38篇 |
一般理论 | 1篇 |
预防医学 | 121篇 |
眼科学 | 3篇 |
药学 | 61篇 |
中国医学 | 4篇 |
肿瘤学 | 140篇 |
出版年
2021年 | 14篇 |
2019年 | 13篇 |
2018年 | 22篇 |
2017年 | 14篇 |
2016年 | 14篇 |
2015年 | 19篇 |
2014年 | 21篇 |
2013年 | 39篇 |
2012年 | 45篇 |
2011年 | 51篇 |
2010年 | 42篇 |
2009年 | 39篇 |
2008年 | 47篇 |
2007年 | 63篇 |
2006年 | 63篇 |
2005年 | 43篇 |
2004年 | 41篇 |
2003年 | 64篇 |
2002年 | 40篇 |
2001年 | 48篇 |
2000年 | 59篇 |
1999年 | 39篇 |
1998年 | 33篇 |
1997年 | 31篇 |
1996年 | 31篇 |
1995年 | 30篇 |
1994年 | 32篇 |
1993年 | 34篇 |
1992年 | 43篇 |
1991年 | 50篇 |
1990年 | 50篇 |
1989年 | 46篇 |
1988年 | 47篇 |
1987年 | 47篇 |
1986年 | 39篇 |
1985年 | 33篇 |
1984年 | 21篇 |
1983年 | 30篇 |
1982年 | 13篇 |
1981年 | 17篇 |
1980年 | 15篇 |
1979年 | 18篇 |
1978年 | 17篇 |
1977年 | 29篇 |
1976年 | 28篇 |
1975年 | 23篇 |
1974年 | 28篇 |
1973年 | 20篇 |
1970年 | 15篇 |
1968年 | 14篇 |
排序方式: 共有1755条查询结果,搜索用时 0 毫秒
111.
While methadone is currently the primary pharmacotherapy used in the treatment of heroin dependence in Australia, levo-alpha-acetyl-methodol (LAAM) and buprenorphine are new pharmacotherapies that are being examined as alternatives to methadone maintenance treatment. The aim of this research is to consider the effects of the methadone, buprenorphine and LAAM, as used in maintenance pharmacotherapy for heroin dependence, upon simulated driving. Clients stabilised in methadone, LAAM and buprenorphine treatment programs for 3 months, and a control group of non-drug-using participants, took part in this study which involved operating a driving simulator over a 75 min period. All participants attended one session without alcohol and one session with alcohol at around the 0.05% blood alcohol level. Simulated driving skill was measured through standard deviations of lateral position, speed and steering wheel angle, and reaction time to a subsidiary task was also measured. While alcohol impaired all measures of driving performance, there were no differences in driving skills across the four participant groups. These findings suggest that typical community standards around driving safety should be applied to clients stabilised in methadone, LAAM and buprenorphine treatment. The findings are important in terms of the widespread implementation of these treatment options in Victoria given that a large proportion of pharmacotherapy clients drive. 相似文献
112.
Chromium as adjunctive treatment for type 2 diabetes 总被引:1,自引:0,他引:1
OBJECTIVE: To review the chemistry, pharmacology, efficacy, and safety of trivalent chromium in the treatment of type 2 diabetes and hyperlipidemia. DATA SOURCES: The English literature was searched from 1966 through May 2002 using MEDLINE, International Pharmaceutical Abstracts, and EMBASE. The key words included chromium, glucose, lipids, and diabetes. Pertinent references from review articles and studies were used as additional sources. DATA SYNTHESIS: Trivalent chromium is an essential nutrient and has a key role in lipid and glucose metabolism. Supplementation with chromium does not appear to reduce glucose levels in euglycemia. It may, however, have some efficacy in reducing glucose levels in hyperglycemia. The effects of chromium on lipid levels are variable. Chromium in doses <1000 microg/d appears to be safe for short-term administration. Kidney function and dermatologic changes need to be monitored. CONCLUSIONS: Chromium appears to be a safe supplement and may have a role as adjunctive therapy for treatment of type 2 diabetes. Additional large-scale, long-term, randomized, double-blind studies examining the effect of various doses and forms of chromium are needed. 相似文献
113.
The aims of this study were to identify (1) the ethics and human rights issues experienced by nurses in leadership roles (NLs); (2) how frequently these issue occurred in the NLs'practices; and (3) how disturbed the NLs were by the issues. Dillman's Total Design Method (1978) for mailed surveys guided the study design. Data analysis was performed on 470 questionnaires from New England RNs in nursing leadership roles. The most frequently experienced ethics and human rights issues during the previous 12 months were (1) protecting patient right and human dignity; (2) respecting or not respecting informed consent to treatment; (3) use or nonuse of physical or chemical restraints; (4) providing care with possible risks to the RN's health; (5) following or not following advance directives; and (6) staffing patterns that limit patient access to nursing care. The most disturbing ethics and human rights issues experienced by the NLs were staffing patterns that limited patient access to nursing care, prolonging the dying process with inappropriate measures, working with unethical, incompetent, or impaired colleagues, implementing managed care policies that threaten quality of care, not considering quality of the patient's life, and caring for patients and families who are uninformed or misinformed about treatment, prognosis, or medical alternatives. Nearly 39% of the NLs reported experiencing ethics and human rights issues one to four times a week or more, and more than 90% handled their most recent ethics issue by discussing it with nursing peers. Study findings have implications for ethics education and resource support for nurses in leadership roles, and for further research on how NLs handle ethics and human rights issues in the workplace. 相似文献
114.
115.
116.
The Coalition of Allied Health Leadership (CAHL) 2000 Representation Team sought 1) to secure Federal advisory appointments for allied health professionals and 2) to connect allied health representatives with Federal advisory committees, councils, boards, and other deliberative bodies. Among the deliberative bodies providing recommendations on a broad range of issues to the President of the United States and the Executive Branch, there are over 1,000 advisory committees, councils, and boards, with more than 20,000 members. Recommendations made by the deliberative bodies include those related to health care. The literature and Web sites reveal allied health professionals have little or no representation on the bodies that represent allied health professionals and their constituents. These findings provide insights into Federal-level deliberative bodies to which allied health professionals have access or on which they warrant representation. This article reports background information, including the CAHL 2000 Representation Team objectives; an overview of federal advisory committees; recommendations for gaining access to deliberative bodies and active participation in fulfillment of Healthy People 2010 goals; and continued commitment to such representation by the CAHL and allied health professionals. 相似文献
117.
Magee LA Redman CW 《European journal of obstetrics, gynecology, and reproductive biology》2000,88(2):203-205
A 29-year-old woman presented post-natally with pulmonary hypertension. Peripheral venous thrombosis was not detected by duplex ultrasound or conventional MRI. Despite anticoagulation, the patient arrested. Autopsy revealed right iliac vein thrombosis. The ability of conventional MRI to detect acute pelvic thrombophlebitis depends on obtaining appropriate views. 相似文献
118.
BACKGROUND: In an effort to prevent falls of pediatric surgical patients from the operating table, a set of portable cushioned operating table siderails was developed. METHODS: A set of portable cushioned operating table siderails was used in the operating room over a 5-year period in more than 2,550 cases. RESULTS: The portable cushioned siderails provided an effective, easily placed barrier to falling. No falls were recorded. CONCLUSIONS: Portable cushioned siderails provide an effective barrier to prevent pediatric surgical patients from falling from the operating table. 相似文献
119.
Evaluating the effectiveness of advocacy training for breast cancer advocates in Australia 总被引:1,自引:0,他引:1
There is growing trend in health care for patients and consumers to have an active voice in all decisions related to their care. The purpose of the current study was to assess the effectiveness of an advocacy training programme for breast cancer consumers in Australia. The participants included 51 women who attended a 3-day advocacy training programme in three different states across Australia. Participants completed a pre- and post-questionnaire at 6 months follow-up to assess their involvement in breast cancer advocacy activities and organizations. Findings revealed a significant increase in participants' involvement in serving as a member of a board or committee, working on clinical trials recruitment issues, working on patient resources, and involvement in breast cancer advocacy groups after completing the training programme. However, no change was found in other key advocacy areas, such as, lobbying for change or reviewing research protocols. Implications for future advocacy training programmes and research were discussed. 相似文献
120.
Phase II trial of oral estramustine, oral etoposide, and intravenous paclitaxel in hormone-refractory prostate cancer. 总被引:2,自引:0,他引:2
D C Smith P Esper M Strawderman B Redman K J Pienta 《Journal of clinical oncology》1999,17(6):1664-1671
PURPOSE: To evaluate the combination of intravenous (IV) paclitaxel, oral estramustine, and oral etoposide in patients with advanced hormone-refractory prostate cancer. PATIENTS AND METHODS: Forty patients with carcinoma of the prostate that was progressing despite hormonal therapy and who had undergone antiandrogen withdrawal (if previously treated with an antiandrogen) were enrolled onto this phase II trial. Patients were treated with oral estramustine 280 mg tid and oral etoposide 100 mg/d for 7 days, with paclitaxel 135 mg/m(2) IV over 1 hour on day 2 of each 21-day treatment cycle. Patients received a maximum of six cycles of therapy. RESULTS: Thirty-seven patients were assessable for response. Twenty-two had measurable disease at baseline; response was not assessable in six of these patients. Overall response was 45% (10 of 22 patients; 95% confidence interval [CI], 24% to 68%), and response was 63% (10 of 16) in assessable patients. Twenty-six patients had a > or = 50% decrease from their baseline prostate-specific antigen levels during therapy, for a response rate of 65% (95% CI, 48% to 79%) by this criterion. Median duration of response was 3.2 months, with an estimated median survival of 12.8 months. Major toxicities of therapy were leukopenia (eight patients had > or = grade 4 leukopenia) and anemia. Hematologic toxicity seemed to be associated with liver metastases. Serial measurements in 24 patients using the Functional Assessment of Cancer Therapy-Prostate (FACT-P) showed no significant change in quality of life (QOL) as a result of therapy. CONCLUSION: The combination of IV paclitaxel, oral estramustine, and oral etoposide is active in patients with advanced prostate cancer. The regimen is tolerable and does not have a significant impact on QOL as measured by the FACT-P in a limited sample of patients. 相似文献