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81.
82.
Extra-osseous masses are rarely seen in Gaucher disease. Here we present a case of a 30-year-old patient with Gaucher disease type 3, receiving β-glucocerebrosidase enzyme replacement therapy, who presented with slowly enlarging masses along her back. There was no osseous extension seen on imaging. Biopsy of the mass ultimately showed extensive soft tissue infiltration by Gaucher cells. No other cases of soft-tissue masses of this extent have been described in the literature, and therefore management remains unclear. 相似文献
83.
84.
Vijaya Kumar Muppiri Syed Nasheed Ali Kumar Ravinuthala Venkat Krishna Lanka Satya Rama 《Indian Journal of Thoracic and Cardiovascular Surgery》2011,27(4):161-164
Introduction
Combined aortic and mitral valve disease is usually of rheumatic origin. In these patients we often encounter problem of small valve annuli particularly with aortic annulus. It is still debated whether a small prosthesis should be used or aortic root should be enlarged to prevent Patient Prosthesis Mismatch (PPM). This study was undertaken to review our strategy and feasibility of Aortic Root Enlargement (ARE) in patient undergo Double Valve Replacement (DVR) to avoid mismatch without increase in cost of treatment, morbidity or mortality. 相似文献85.
Niraj N. Mahajan 《Archives of gynecology and obstetrics》2009,279(6):853-855
Introduction Creation of the bladder flap, i.e., dissecting the urinary bladder from the lower segment of the uterus is a standard part
of cesarean section (CS). However, it is yet to be established whether the formation of bladder flap is advantageous.
Review of literature Pelosi and Ortega in 1994 introduced a new minimally invasive technique of CS, which included the omission of bladder dissection
together with other modifications. Omission of the bladder flap provides short-term benefits such as reduction of operating
time and incision-delivery interval, wound infection, reduced blood loss and analgesic requirement. In addition, it is associated
with good long-term outcomes with regards to adhesion formation.
Conclusion Further large-scale controlled randomized clinical trials are needed to investigate the safety of this technique with respect
to in deeply engaged head, preterm, subsequent pregnancies and trial of labor and also to determine the future role of this
technique that will contribute to advancement and popularity of this technique amongst obstetricians. 相似文献
86.
Sharma A Mahajan S Gupta ML Kanga A Sharma V 《Japanese journal of infectious diseases》2005,58(4):208-210
In Indira Gandhi Medical College, Himachal Pradesh, India, during autumn of 2003 (September-November), more than 100 cases of fever of unknown origin (FUO) were reported with 15 ensuing deaths. In addition to all routine investigations and cultures, the Weil-Felix test was incorporated for the investigation of these cases. Antigen was procured from the Central Research Institute, Kasauli. Forty-six percent (45/96) of the cases demonstrated a > or =1:80 titer of agglutinins against OXK antigen. A team from the National Institute of Communicable Diseases, New Delhi, confirmed the antibodies for scrub typhus in some of the serum samples tested for leptospirosis, dengue fever, and rickettsial infections. Twelve blood samples positive for OXK antigen were sent to the Defense Research Development Establishment, Gwalior, for polymerase chain reaction studies, but none of the samples were positive, as all of the patients were already on broad-spectrum antibiotics and had reported to our hospital after 7-10 days of fever. At our institute, the Weil-Felix test has now been rountinely introduced for the investigation of cases of FUO, and the results until April 2004 (150 cases) revealed the presence of other rickettsial infections prevalent in the region. To evaluate the epidemiology and magnitude of the problem, further prospective studies are required. 相似文献
87.
Immunization among the high risk groups, including the elderly, remains unacceptably low for pneumococcal and influenza vaccines.
This study determined the factors which influence pneumococcal vaccine compliance in the aged. A questionnaire developed for
this study was mailed to all 300 veterans in west central Florida who were 85 years or older and were eligible for ambulant
medical care at the James A. Haley Veterans Hospital, Tampa, Florida. They were asked regarding circumstances which influenced
their decision for or against accepting pneumococcal vaccine. Ninety-two persons responded in self-addressed stamped envelopes
and data were analyzed six months following mailing date. The single most important factor for not accepting vaccination was
lack of information and unawareness that the immunization was necessary (81%). Fear of “shots” and side effects was the next
most important reason for not taking the vaccine (15%). Lack of transportation to the doctor’s office prevented 12% of the
subjects. Some subjects also did not have an interest in prophylactic immunization (8%).
These data suggest that the lack of awareness, knowledge and information about pneumococcal immunization plays major roles
in its poor acceptance among the elderly. Health education measures should improve vaccine compliance in this population who
suffer from higher death rates and complications from pneumonia. 相似文献
88.
Kumarasamy N Solomon S Chaguturu SK Mahajan AP Flanigan TP Balakrishnan P Mayer KH 《AIDS (London, England)》2003,17(15):2267-2269
We investigated the safety, tolerability and effectiveness of locally produced generic highly active antiretroviral therapy (HAART) regimens with a chart review conducted at YRG CARE, a tertiary HIV referral centre in India. A total of 333 patients had been on Indian-manufactured generic HAART for at least 3 months. In this cohort, generic HAART was safe, well tolerated and effective at increasing CD4 T-lymphocyte counts in patients with advanced HIV, comparable to the experience with proprietary HAART. 相似文献
89.
Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region
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90.
Summary The extent of reduced glutathione, activity of glutathione peroxidase, amount of membrane lipid peroxidation products, and the extent of hemoglobin release from host erythrocytes during in vitroPlasmodium falciparum growth was studied. Highly synchronized parasite cultures were studied to examine the alterations caused by different growth stages of the parasite. There was a moderate increase in the reduced glutathione content as the parasite matured, which was significant only in schizontrich erythrocyte lysates (p<0.05) whereas the activity of glutathione peroxidase was significantly low in all the parasitized red blood cells (ring-infected RBC,p<0.005; trophozoite- and schizont-infected RBC,p<0.001). The lipid peroxidation product, malonyldialdehyde, of the host red cells increased gradually to more than fourfold in schizont-rich cells as compared with normal erythrocytes (p<0.001). The hemoglobin release from cultured cells was significantly higher in all parasitized red cell cultures as well as in uninfected cells kept in in vitro, as compared with normal erythrocytes. The consequence of such changes induced by the malarial parasites in the host red cells in the pathogenesis of erythrocyte destruction and anemia ofP. falciparum malaria is discussed. 相似文献