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Rajat Dhar 《Neurocritical care》2018,28(1):4-11
Neurologic disturbances including encephalopathy, seizures, and focal deficits complicate the course 10–30% of patients undergoing organ or stem cell transplantation. While much or this morbidity is multifactorial and often associated with extra-cerebral dysfunction (e.g., graft dysfunction, metabolic derangements), immunosuppressive drugs also contribute significantly. This can either be through direct toxicity (e.g., posterior reversible encephalopathy syndrome from calcineurin inhibitors such as tacrolimus in the acute postoperative period) or by facilitating opportunistic infections in the months after transplantation. Other neurologic syndromes such as akinetic mutism and osmotic demyelination may also occur. While much of this neurologic dysfunction may be reversible if related to metabolic factors or drug toxicity (and the etiology is recognized and reversed), cases of multifocal cerebral infarction, hemorrhage, or infection may have poor outcomes. As transplant patients survive longer, delayed infections (such as progressive multifocal leukoencephalopathy) and post-transplant malignancies are increasingly reported. 相似文献
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Anisha Seth Rajat Gupta Anika Gupta Usha K Raina Basudeb Ghosh 《Indian journal of ophthalmology》2015,63(4):346-348
Optic disc pit (ODP) is small, gray-white, oval depression found at the optic nerve head. It is a congenital defect that occurs due to imperfect closure of superior edge of the embryonic fissure. Cleft lip and palate are also congenital midline abnormalities occurring due to defect in the fusion of frontonasal prominence, maxillary prominence and mandibular prominence. There is only one case report describing the occurrence of ODP in a young patient with cleft lip and palate who also had basal encephalocele. We describe a 52-year-old patient with congenital cleft lip and palate with bilateral ODP with maculopathy but without any other midline abnormality. 相似文献
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Naga Venkata K. Pothineni MD Nigel Amankwah MD Pasquale Santangeli MD PhD Robert D. Schaller DO Gregory E. Supple MD Rajat Deo MD Saman Nazarian MD Fermin C. Garcia MD Sanjay Dixit MD David J. Callans MD Francis E. Marchlinski MD David S. Frankel MD 《Journal of cardiovascular electrophysiology》2021,32(2):345-353
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Mohindra R Pannu HS Mohan B Kumar N Dhooria HS Sehgal A Avasthi G 《Indian heart journal》2004,56(6):668-669
Rheumatic fever is a multi system disease which occurs following infection with group A beta hemolytic streptococcus. It is commonest in the age group of 5-15 years but can occur in adults also. First degree atrioventricular block is a common manifestation of acute rheumatic fever and is included in the Jones criteria but Wenckebacks phenomena and complete heart block are relatively rare manifestations of rheumatic fever. Syncope occurring in acute rheumatic fever is also infrequently reported. We report the case of a 38-year-old male with rheumatic carditis who had advanced atrioventricular block which resulted in syncope and required a temporary pacemaker insertion. 相似文献
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