Ocular toxocarosis--as an example of diagnostic and therapeutic difficulties

Diagnostic and therapeutic problems of ocular toxocarosis in patients with late pathological changes was observed. Multispecialistic methods (ophtalmological, radiological, immunoserological) in evaluation of patients were used. In the course of prolonged observation of patients treated many times with albendazole (Zentel, Smith Kline and Beecham GB) no improvement of vision and no regression of late and irreversible ocular pathology were noted.     

Bringing end-of-life care out of the shadows

Understand what resources are available to help you incorporate palliative and end-of-life care into your nursing practice.     

The use of nitric oxide in neonatal care

Knowledge of NO and its role in the human body currently is limited. Further scientific research involving this unique molecule will expand its clinical usefulness. It is an exciting era in research,involving numerous body processes and systems.The initial work on pulmonary vascular response in newborns who have PPHN has opened the door to seemingly endless possibilities involving many aspects of health.     

Nursing undergraduate students and their relationship with smoking

This study was designed to investigate: the prevalence of smokers among the UNIFESP nursing undergraduate students; some initial usage features; the smokers' dependence degree on nicotine. In order to compare the ratio of some variables, Pearson's Square Chi test was applied. The number of smokers among the nursing undergraduate students in the sample was 23 (8.2%) and 167 (59.9%) said they had never smoked a cigarette. Smokers' average age was 19.5 years old, and there is a significant difference between genders and only 2 (9.1%) smoking students may show a more severe discomfort while attempting to stop smoking, as showed the Fagerstr?m's Test.     

Synthesis and antiproliferative activity in vitro of 2-aminobenzimidazole derivatives

A novel series of Schiff bases 1-11, the derivatives of 2-aminobenzimidazole and substituted aromatic aldehydes, has been synthesised. Compounds 1-11 reduced by NaBH(4) formed 2-benzylaminobenzimidazoles 12-21. 2-(o-Bromobenzylamino)benzimidazole (15) acylated by cinnamoyl chloride gave 2-(o-bromobenzylamino)-1-cinnamoylbenzimidazole (22). Long heating of 15 and 19 with p-nitrocinnamoyl or cinnamoyl chloride led to the formation of pyrimido[1,2-a]benzimidazol-4-ones 23 and 24. The structures of 1-24 were identified by the results of elemental analysis and their IR, (1)H NMR and MS spectra. Among the compounds 1-24 evaluated for their antiproliferative activity in vitro, 16, 19, 20 and 22 exhibited cytotoxic activity against the cells of human cancer cell lines, namely SW707 (rectal), HCV29T (bladder), A549 (lung) and T47D (breast cancer).