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971.
972.
José Miguel Baena-Díez Isaac Subirana Rafael Ramos Agustín Gómez de la Cámara Roberto Elosua Joan Vila Alejandro Marín-Ibáñez María Jesús Guembe Fernando Rigo María José Tormo-Díaz Conchi Moreno-Iribas Joan Josep Cabré Antonio Segura José Lapetra Miquel Quesada María José Medrano Paulino González-Diego Guillem Frontera Jaume Marrugat 《Revista espa?ola de cardiología》2018,71(4):274-282
Introduction and objectives
To assess the validity of the original low-risk SCORE function without and with high-density lipoprotein cholesterol and SCORE calibrated to the Spanish population.Methods
Pooled analysis with individual data from 12 Spanish population-based cohort studies. We included 30 919 individuals aged 40 to 64 years with no history of cardiovascular disease at baseline, who were followed up for 10 years for the causes of death included in the SCORE project. The validity of the risk functions was analyzed with the area under the ROC curve (discrimination) and the Hosmer-Lemeshow test (calibration), respectively.Results
Follow-up comprised 286 105 persons/y. Ten-year cardiovascular mortality was 0.6%. The ratio between estimated/observed cases ranged from 9.1, 6.5, and 9.1 in men and 3.3, 1.3, and 1.9 in women with original low-risk SCORE risk function without and with high-density lipoprotein cholesterol and calibrated SCORE, respectively; differences were statistically significant with the Hosmer-Lemeshow test between predicted and observed mortality with SCORE (P < .001 in both sexes and with all functions). The area under the ROC curve with the original SCORE was 0.68 in men and 0.69 in women.Conclusions
All versions of the SCORE functions available in Spain significantly overestimate the cardiovascular mortality observed in the Spanish population. Despite the acceptable discrimination capacity, prediction of the number of fatal cardiovascular events (calibration) was significantly inaccurate.Full English text available from:www.revespcardiol.org/en 相似文献973.
M. Cecilia Gonzalez Corcia Juan Sieira Gudrun Pappaert Carlo de Asmundis Gian Battista Chierchia Mark La Meir Andrea Sarkozy Pedro Brugada 《Journal of the American College of Cardiology》2018,71(2):148-157
Background
Young patients presenting with symptomatic Brugada syndrome have very high risks for ventricular arrhythmias and should be carefully considered for implantable cardioverter-defibrillator (ICD) placement. However, this therapy is associated with high rates of inappropriate shocks and device-related complications.Objectives
This study investigated clinical features, management, and long-term follow-up of young patients with Brugada syndrome and ICD.Methods
Patients diagnosed with Brugada syndrome, who underwent implantation of an ICD at an age of ≤20 years, were studied.Results
The study included 35 consecutive patients. The mean age at ICD placement was 13.9 ± 6.2 years. Ninety-two percent were symptomatic; 29% presented with aborted sudden cardiac death and 63% with syncope. During a mean follow-up period of 88 months, sustained ventricular arrhythmias were treated by the ICD in 9 patients (26%), including shocks in 8 patients (23%) and antitachycardia pacing in 1 patient (3%). Three patients (9%) died in an electrical storm. Seven patients (20%) experienced inappropriate shocks, and 5 patients (14%) had device-related complications. Aborted sudden cardiac death and spontaneous type I electrocardiogram were identified as independent predictors of appropriate shock occurrence.Conclusions
ICD therapy is an effective strategy in young patients with symptomatic Brugada syndrome, treating potentially lethal arrhythmias in >25% of patients during follow-up. Appropriate shocks were significantly associated with previously aborted sudden cardiac death and spontaneous type I electrocardiograms. However, ICDs are frequently associated with complications and inappropriate shocks, both of which remain high regardless of careful device implantation and programming. 相似文献974.
Glória Abreu Carlos Galvão Braga João Costa Pedro Azevedo Jorge Marques 《Revista portuguesa de cardiologia》2018,37(8):707-713
Background
Spontaneous coronary artery dissection (SCAD) is an unusual cause of acute coronary syndrome (ACS). Better recognition and diagnosis has raised awareness of this condition. However, the pathophysiology of SCAD and its prognosis are still little understood. We aimed to investigate the characteristics and prognosis of patients with SCAD, and subsequently performed a review of literature.Methods
Single-center, retrospective study performed in patients hospitalized from January 2010 to December 2016 with suspected ACS (n=5002) whose final diagnosis was SCAD (n=27; 0.5%).Results
Patients with SCAD were mainly female (81.5%; n=22), with median age of 56. Predisposing factors were identified in 12 (44%) patients and precipitating factors in three (11.1%). Non-ST elevation myocardial infarction (NSTEMI) was the main form of presentation (51.9%). The left anterior descending artery (LAD) territory was the most commonly involved (n=12, 44.4%). Type 2 dissection was the most prevalent angiographic pattern (n=17, 63%). The majority of patients (n=15; 55.6%) were managed medically and the remaining patients underwent percutaneous coronary intervention (PCI) with drug-eluting stents. Seven patients re-infarcted while in the hospital. Over the median follow-up period of 20 months, 7.4% of patients (n=2) had symptoms of heart failure (HF) and 14.8% developed ACS (in three patients the event occurred in a coronary territory other than that of the index case, and in one patient it occurred in the previously affected territory). There were no deaths.Conclusion
In the studied population, SCAD was more prevalent in middle-aged women. Despite the high prevalence of in-hospital re-infarction or during follow-up, the prognosis was good overall. 相似文献975.
Fredric Assis Oliveira Pedro A. Lemos 《Catheterization and cardiovascular interventions》2020,96(2):422-423
- Chronic thrombocytopenia is frequent in patients undergoing TAVR in the real world.
- Chronic thrombocytopenia is associated with worse in‐hospital outcomes after TAVR.
- Future research is necessary to establish a better way of conducting and monitoring these patients.
976.
Luís Alberto Garcia Freitas Sandro dos Santos Ferreira Rosemari Queiroz Freitas Carlos Henrique de Souza Erick Doner Santos de Abreu Garcia Sergio Gregorio da Silva 《Journal of Physical Therapy Science》2015,27(7):2221-2224
[Purpose] The aim of this study was to observe the effect of self-selected intensity or
imposed intensity during aerobic training on perceptual and affective responses in obese
women. [Subjects] The study included 26 obese women aged 30–60 years. [Methods] The
subjects were randomly divided into two groups, with 13 subjects in each group:
self-selected intensity and imposed intensity (10% above ventilatory threshold) groups.
All subjects completed an intervention program that lasted 12 weeks, with three exercise
sessions a week. The rating of perceived exertion and affective responses (Feeling Scale
and Felt Arousal Scale) were monitored in the first, sixth, and twelfth weeks. [Results]
Significant differences were observed between groups in heart rate and rating of perceived
exertion. The affective responses during exercise were more negative in the imposed
intensity group. [Conclusion] Use of a self-selected exercise intensity can promote
smaller negative affective responses during exercise and provide a sufficient stimulus for
improvement in cardiorespiratory fitness.Key words: Self-selected exercise, Rating of perceived exertion, Affective responses 相似文献
977.
Maria Lúcia R de Rezende Pedro T.G. Coesta Rodrigo C. de Oliveira Samira Salmeron Adriana C.P. Sant'Ana Carla A. Damante Sebastião L.A. Greghi Alberto Consolaro 《Journal of periodontology》2015,86(1):146-154
Background: Previous studies have demonstrated that bone demineralization can improve consolidation in bone grafts. The biologic mechanisms underlying this phenomenon remain unclear. Methods: Twelve adult male guinea pigs were used in this experiment. Forty‐five bone samples removed from the calvaria of nine animals were divided in groups (n = 9) according to the time of demineralization with citric acid (50%, pH 1): 15, 30, 90, and 180 seconds and non‐demineralized samples (control). Preosteoblasts (MC3T3‐E1) were cultured on the bone samples for 24, 48, and 72 hours (n = 3). Fifteen samples removed from the remaining three animals were analyzed by scanning electron microcopy/energy dispersive spectrometry (SEM/EDS) after demineralization (n = 3). Results: The number of preosteoblasts increased significantly with time in all groups. The bone surface area covered by these cells increased with time, except in the control group. Intragroup differences occurred between 24 and 72 hours (P <0.05). Samples demineralized for 30 seconds showed greater area covered by preosteoblast cells than for the other times of demineralization in all periods of cell culture (P <0.05) without a statistically significant difference compared with 15 seconds. SEM/EDS showed diminished content of calcium (Ca) after 15 seconds of demineralization, but the Ca content increased after 180 seconds of demineralization (P <0.05). The phosphorus (P) amount increased significantly only after 30 seconds of demineralization (P <0.5). The sulfur (S) content was increased in demineralized samples in relation to non‐demineralized ones, reaching the highest level after 90 seconds, when the difference became significant in relation to all the other times of demineralization (P <0.05). Magnesium (Mg) content did not differ significantly between demineralized and non‐demineralized samples. Conclusions: Bone surfaces demineralized for 30 seconds increased the spreading of preosteoblasts as well as the surface area covered by these cells. Bone demineralization deserves to be studied in periodontal and maxillofacial regenerative procedures. 相似文献
978.
Adjuvant Therapy With Sodium Alendronate for the Treatment of Experimental Periodontitis in Rats
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Juliano De Almeida Edilson Ervolino Luiz Henrique Bonfietti Vivian Cristina Noronha Novaes Letícia Helena Theodoro Leandro Araujo Fernandes Thiago Marchi Martins Paula Lazilha Faleiros Valdir Gouveia Garcia 《Journal of periodontology》2015,86(10):1166-1175
Background: This study assesses the effects of topical sodium alendronate (SA) as an adjuvant to the mechanical treatment of ligature‐induced periodontitis in rats. Methods: Ninety animals were subjected to the induction of periodontitis via the installation of a ligature around the mandibular left first molar. After 7 days, the ligature was removed, and the animals were distributed into the following groups: 1) NT group (n = 30), no treatment; 2) SRP group (n = 30), scaling and root planing (SRP) and local irrigation with physiologic saline solution; and 3) SRP/SA group (n = 30), SRP and local irrigation with SA (10?5 M). Ten animals from each group were euthanized at 7, 15, and 30 days after treatment. Histologic and histometric analyses were performed in the furcation region. The percentage of bone in the furcation (PBF) was measured. Immunohistochemical analyses for detecting the receptor activator of nuclear factor‐κB ligand (RANKL), osteoprotegerin (OPG), tartrate‐resistant acid phosphatase (TRAP), and activated caspase‐3 were performed at the furcation region. Results: Compared with the other groups, the SRP/SA group showed less local inflammation and better tissue reparation during the entire experiment. There was more PBF in the SRP/SA group than in the other groups at days 7 and 15. Stronger OPG immunolabeling and weaker RANKL immunolabeling were observed in the SRP/SA group at 15 and 30 days. There were fewer TRAP‐positive cells in the SRP/SA group than in the NT group at all of the time points. There was no difference in the number of activated caspase‐3‐positive osteocytes among groups and time points. Conclusion: It can be concluded that topical use of SA as an adjuvant to SRP is effective in the treatment of experimental periodontitis. 相似文献
979.
Dental service utilization and neighborhood characteristics in young adults in the United States: a multilevel approach
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980.
Examination criteria and calibration procedures for prevention trials of the Early Childhood Caries Collaborating Centers
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