全文获取类型
收费全文 | 1837篇 |
免费 | 166篇 |
国内免费 | 11篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 131篇 |
妇产科学 | 22篇 |
基础医学 | 183篇 |
口腔科学 | 53篇 |
临床医学 | 274篇 |
内科学 | 359篇 |
皮肤病学 | 18篇 |
神经病学 | 58篇 |
特种医学 | 223篇 |
外科学 | 273篇 |
综合类 | 46篇 |
一般理论 | 2篇 |
预防医学 | 140篇 |
眼科学 | 49篇 |
药学 | 99篇 |
1篇 | |
中国医学 | 2篇 |
肿瘤学 | 80篇 |
出版年
2021年 | 11篇 |
2019年 | 16篇 |
2018年 | 23篇 |
2017年 | 28篇 |
2016年 | 18篇 |
2015年 | 34篇 |
2014年 | 42篇 |
2013年 | 51篇 |
2012年 | 50篇 |
2011年 | 47篇 |
2010年 | 55篇 |
2009年 | 60篇 |
2008年 | 55篇 |
2007年 | 26篇 |
2006年 | 43篇 |
2005年 | 38篇 |
2004年 | 38篇 |
2003年 | 34篇 |
2002年 | 50篇 |
2001年 | 33篇 |
2000年 | 28篇 |
1999年 | 46篇 |
1998年 | 99篇 |
1997年 | 99篇 |
1996年 | 102篇 |
1995年 | 66篇 |
1994年 | 64篇 |
1993年 | 55篇 |
1992年 | 61篇 |
1991年 | 52篇 |
1990年 | 24篇 |
1989年 | 49篇 |
1988年 | 39篇 |
1987年 | 56篇 |
1986年 | 38篇 |
1985年 | 47篇 |
1984年 | 32篇 |
1983年 | 30篇 |
1982年 | 18篇 |
1981年 | 22篇 |
1980年 | 17篇 |
1979年 | 16篇 |
1978年 | 19篇 |
1977年 | 20篇 |
1976年 | 20篇 |
1975年 | 16篇 |
1973年 | 12篇 |
1972年 | 13篇 |
1969年 | 10篇 |
1966年 | 11篇 |
排序方式: 共有2014条查询结果,搜索用时 15 毫秒
41.
Campath IH allows low-dose cyclosporine monotherapy in 31 cadaveric renal allograft recipients 总被引:14,自引:0,他引:14
Calne R Moffatt SD Friend PJ Jamieson NV Bradley JA Hale G Firth J Bradley J Smith KG Waldmann H 《Transplantation》1999,68(10):1613-1616
BACKGROUND: Campath 1H is a depleting, humanized anti-CD52 monoclonal antibody that has now been used in 31 renal allograft recipients. The results have been very encouraging and are presented herein. METHODS: Campath 1H was administered, intravenously, in a dose of 20 mg, on day 0 and day 1 after renal transplant. Low-dose cyclosporine (Neoral) was then initiated at 72 hr after transplant. These patients were maintained on low-dose monotherapy with cyclosporine. RESULTS: At present, the mean follow-up is 21 months (range: 15-28 months). All but one patient are alive and 29 have intact functioning grafts. There have been six separate episodes of steroid-responsive rejection. One patient has had a recurrence of her original disease. Two patients have suffered from opportunistic infections, which responded to therapy. One patient has died secondary to ischemic cardiac failure. CONCLUSIONS: Campath 1H has resulted in acceptable outcomes in this group of renal allograft recipients. This novel therapy is of equal efficacy compared to conventional triple therapy, but allows the patient to be steroid-free and to be maintained on very-low-dose immunosuppressive monotherapy. 相似文献
42.
MJ Stevens PD Stricker J Saalfeld PC Brenner R Kooner GFA O'Neill PJ Duval RS Jagavkar P Cross J Martland 《Journal of Medical Imaging and Radiation Oncology》2003,47(2):152-160
Combination high dose rate brachytherapy (HDRB) and external beam radiation therapy is technically and clinically feasible as definitive treatment for localized prostate cancer. We report the first large Australian experience using this technique of radiation dose escalation in 82 patients with intermediate‐ and high‐risk disease. With a median follow up of 3 years (156 weeks), complications were low and overall prostate‐specific antigen progression‐free survival was 91% using the American Society for Therapeutic Radiology and Oncology consensus definition. The delivery of hypofractionated radiation through the HDRB component shortens overall treatment time and is both biologically and logistically advantageous. As a radiation boost strategy, HDRB is easy to learn and could be introduced into most facilities with brachytherapy capability. 相似文献
43.
Screening for complement deficiency in bacterial meningitis 总被引:1,自引:0,他引:1
T Ernst PJ Späth C Aebi UB Schaad MG Bianchetti 《Acta paediatrica (Oslo, Norway : 1992)》1997,86(9):1009-1010
Seventy-seven children with bacterial meningitis were screened for complement deficiency. Both the classical and the alternate pathways were normal in 75 patients. Transiently reduced total haemolytic activity of the classical pathway was documented in a boy with meningococcal meningitis. Total haemolytic activity of both the classical and the alternate pathways were reduced in another patient with pneumococcal meningitis: individual complement components determination indicated predominant activation of the alternate pathway. 相似文献
44.
JJ Rangasami DC Greenwood B McSporran PJ Smail CC Patterson NR Waugh 《Archives of disease in childhood》1997,77(3):210-213
OBJECTIVES: To calculate the incidence of type 1 diabetes in Scottish children aged less than 15 years between 1984 and 1993; to examine changes in incidence; and to calculate the prevalence of diabetes at the end of this period. DESIGN: Three data sources were used to construct the Scottish Study Group for the Care of Young Diabetics register: active reporting of all new cases; reports from the Scottish Morbidity Register 1; and local registers. SUBJECTS: All children resident in Scotland diagnosed with primary insulin dependent diabetes mellitus when less than 15 years of age between 1984 and 1993. MAIN OUTCOME MEASURES: Annual incidence and prevalence rate for Scotland; time trend in incidence over the 10 years; differences in incidence between the three different age groups; and completeness of the register. RESULTS: The average annual incidence for Scotland was 23.9/100,000 children. The prevalence rate was 1.5/1000 in 1993. A total of 2326 cases was identified from the three sources. Capture-recapture analysis suggests a case ascertainment of 98.6%. The annual incidence rates increased at a rate of 2% each year (rate ratio = 1.02, 95% confidence interval (CI) 1.01 to 1.03). The incidence was higher in boys than girls (rate ratio = 1.08, 95% CI 1.00 to 1.18), and the incidence rates increased with age: 15.3/100,000/year for age 0-4 years, 24.4/ 100,000/year for age 5-9 years, and 31.9/ 100,000/year for age 10-14 years. CONCLUSIONS: The incidence of type 1 diabetes in Scotland is increasing and the prevalence is relatively high. These findings have important implications for health service resource allocation. The Scottish Study Group for the Care of Young Diabetics' register provides a base for monitoring and research. 相似文献
45.
46.
47.
48.
The major burden of preterm birth is in the developing world, where most of the increasing death and morbidity is secondary to infectious diseases such as malaria, HIV, tuberculosis, bacterial vaginosis and intestinal parasites. In some developing countries, the growth of medical care has outstripped the growth of preventive public health, with an associated increase in iatrogenic preterm births. In developed countries, more than one-third of preterm births are medically indicated because of conditions such as fulminating pre-eclampsia or severe intrauterine growth restriction. Neither of these conditions is currently preventable. One in five preterm births is associated with multiple pregnancy, and these have been greatly increased by assisted reproduction techniques. The use of tocolytics has proved disappointing perhaps because inflammation rather than spontaneous uterine activity is increasingly recognised as the final common pathway. Inappropriate antibiotics used late in pregnancy are ineffective and may have adverse effects. Currently, the most promising interventions are public health related and include reducing the transmission of communicable diseases, improvements in the management of diabetes and reduction in harmful behaviours such as smoking and drug abuse. 相似文献
49.
Annemarie Weissenbacher Honglei Huang Tomas Surik Maria L. Lo Faro Rutger J. Ploeg Constantin C. Coussios Peter J. Friend Benedikt M. Kessler 《American journal of transplantation》2021,21(5):1740-1753
We describe a proteomics analysis to determine the molecular differences between normothermically perfused (normothermic machine perfusion, NMP) human kidneys with urine recirculation (URC) and urine replacement (UR). Proteins were extracted from 16 kidney biopsies with URC (n = 8 donors after brain death [DBD], n = 8 donors after circulatory death [DCD]) and three with UR (n = 2 DBD, n = 1 DCD), followed by quantitative analysis by mass spectrometry. Damage-associated molecular patterns (DAMPs) were decreased in kidney tissue after 6 hours NMP with URC, suggesting reduced inflammation. Vasoconstriction was also attenuated in kidneys with URC as angiotensinogen levels were reduced. Strikingly, kidneys became metabolically active during NMP, which could be enhanced and prolonged by URC. For instance, mitochondrial succinate dehydrogenase enzyme levels as well as carbonic anhydrase were enhanced with URC, contributing to pH stabilization. Levels of cytosolic and the mitochondrial phosphoenolpyruvate carboxykinase were elevated after 24 hours of NMP, more prevalent in DCD than DBD tissue. Key enzymes involved in glucose metabolism were also increased after 12 and 24 hours of NMP with URC, including mitochondrial malate dehydrogenase and glutamic-oxaloacetic transaminase, predominantly in DCD tissue. We conclude that NMP with URC permits prolonged preservation and revitalizes metabolism to possibly better cope with ischemia reperfusion injury in discarded kidneys. 相似文献
50.
Maikel Wijtmans Ewald Edink Oscar PJ van Linden Yang Zheng Antoni R Blaazer Marco Siderius Jacqueline E van Muijlwijk-Koezen 《Drug discovery today》2021,26(6):1359-1368
- Download : Download high-res image (93KB)
- Download : Download full-size image