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121.
Omer Toprak 《Renal failure》2013,35(3):387-388
Radiological procedures require the intravascular administration of iodinated contrast media, which are becoming a great source of an iatrogenic disease known as contrast-induced nephropathy. The development of contrast-induced nephropathy is associated with prolonged hospitalization, the potential need for renal replacement therapy, and increased mortality. Despite numerous clinical and experimental studies, several important issues regarding contrast-induced nephropathy remain controversial. One of the controversial points is its very definition: a universally accepted definition of contrast-induced nephropathy does not exist. This can be a major problem. Differing definitions of contrast-induced nephropathy and the clinical importance of these definitions were discussed in this letter. 相似文献
122.
Asaf Vivante Michal Mark-Danieli Miriam Davidovits Orit Harari-Steinberg Dorit Omer Yehudit Gnatek Roxana Cleper Daniel Landau Yael Kovalski Irit Weissman Israel Eisenstein Michalle Soudack Haike Reznik Wolf Naomi Issler Danny Lotan Yair Anikster Benjamin Dekel 《Journal of the American Society of Nephrology : JASN》2013,24(4):550-558
123.
Muhammet Fuat Ozcan Omer Dizdar Nazmiye Dincer Serdar Balcı Gulnur Guler Bahri Gok Gokhan Pektas Mehmet Metin Seker Sercan Aksoy Cagatay Arslan Suayib Yalcin Mevlana Derya Balbay 《Urologic oncology》2013,31(8):1709-1715
PurposeExcision repair cross-complementation group 1 enzyme (ERCC1) plays a key role in the removal of platinum induced DNA adducts and cisplatin resistance. Prognostic role of ERCC1 expression in the neoadjuvant setting in bladder cancer has not been reported before. We evaluated the prognostic role of ERCC1 expression in bladder cancer receiving platinum-based neoadjuvant chemotherapy.Materials and methodsThirty-eight patients with muscle invasive bladder cancer who received neoadjuvant platinum-based chemotherapy were included. Clinical and histopathologic parameters along with immunohistochemical ERCC1 staining were examined and correlated with response rates and survival.ResultsPathologic complete response rates were similar between patients with low and high ERCC1 expression. Median disease-free survival (DFS) was 9.3 vs. 20.5 months (P = 0.186) and median overall survival (OS) was 9.3 vs. 26.7 months (P = 0.058) in patients with high ERCC1 expression compared with those with low expression, respectively. In multivariate Cox regression analysis: pathological complete response (pCR) after chemotherapy (hazard ratio (HR) 0.1, 95% CI 0.012–0.842, P = 0.034) and high ERCC1 expression (HR 3.7, 95% CI 1.2–11.2, P = 0.019) were significantly associated with DFS. Patient age (>60 vs. ≤60 years) (HR 3.4, 95% CI 1.2–9.4, P = 0.018), the presence of pCR (HR 0.11, 95% CI 0.014–0.981, P = 0.048) and high ERCC expression (HR 6.1, 95 CI 1.9–19.9, P = 0.002) were significantly associated with OS.ConclusionsOur results showed that high ERCC1 expression was independently associated with shorter disease-free and overall survival in patients with bladder cancer who received neoadjuvant platinum-based chemotherapy. ERCC1 may represent a potential predictive marker for platinum-based treatment in bladder cancer. 相似文献
124.
125.
Toker H, Akp?nar A, Ayd?n H, Poyraz O. Influence of smoking on interleukin‐1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment. J Periodont Res 2012; 47: 572–577. © 2012 John Wiley & Sons A/S Background and Objective: The aim of this study was to evaluate the impact of smoking on the relationship between interleukin‐1 (IL‐1β) and oxidation in patients with periodontitis and response to nonsurgical periodontal therapy. Material and Methods: Data were obtained from 30 patients with generalized chronic periodontitis (15 smokers and 15 nonsmokers) and from 10 periodontally healthy controls. IL‐1β level, total oxidant status (TOS) and total antioxidant status (TAS) were recorded in gingival crevicular fluid. Probing depth, clinical attachment level, gingival and plaque indices and bleeding on probing were also measured. The gingival crevicular fluid and clinical parameters were recorded at baseline and 6 wk after periodontal treatment. Results: The study showed statistically significant improvement of clinical parameters in both smokers and nonsmokers after periodontal treatment. Moreover, the baseline IL‐1β levels were significantly higher in smokers compared with nonsmokers (p < 0.05). After periodontal treatment, the IL‐1β levels were significantly reduced in both smokers and nonsmokers (p < 0.05). There were no significant differences in TOS and TAS between periodontitis patients and healthy controls at baseline and 6 wk after periodontal treatment. The level of IL‐1β in gingival crevicular fluid was positively correlated with TOS in both smokers and nonsmokers. Conclusions: Periodontal treatment improved the clinical parameters in both smokers and nonsmokers. The results confirm that periodontal therapy has an effect on IL‐1β levels in gingival crevicular fluid, but not on TOS and TAS. 相似文献
126.
Omer Zarchi Miri Carmel Chen Avni Josef Attias Amos Frisch Elena Michaelovsky Miriam Patya Tamar Green Ronnie Weinberger Abraham Weizman Doron Gothelf 《Journal of psychiatric research》2013
22q11.2 deletion syndrome (22q11.2DS) is a common genetic risk factor for the development of schizophrenia. We investigated two neurophysiological endophenotypes of schizophrenia – P50 sensory gating and mismatch negativity in 22q11.2DS subject and evaluated their association with catechol O-methyltransferase (COMT) and proline dehydrogenase (PRODH) genetic variants. We also assessed the association of neurophysiological measures with schizophrenia-like symptomatology in 22q11.2DS. Fifty-nine subjects, 41 with 22q11.2DS and 18 typically developing controls, participated in the study. The participants with 22q11.2DS were genotyped for the COMT Val158Met (rs4680) and PRODH Gln19Pro (rs2008720) and Arg185Trp (rs4819756) polymorphisms. Following psychiatric evaluation, all the participants underwent neurophysiological recordings and executive function assessment. The 22q11.2DS group showed poorer sensory gating of the P50 response than the controls. Within the 22q11.2DS group, the COMT Met allele was associated with poorer sensory gating, while both the COMT Met allele and the PRODH Pro-Arg haplotype were associated with smaller mismatch negativity amplitudes. Smaller mismatch negativity amplitudes predicted greater impairment of executive functions and greater severity of schizophrenia-like negative symptoms in 22q11.2DS. The current study demonstrates that sensory gating impairments that are typical of schizophrenia are found in 22q11.2DS subjects. Our results further suggest that COMT and PRODH genetic variations contribute to sensory gating and mismatch negativity schizophrenia-like impairments in 22q11.2DS, possibly via dopaminergic/glutamatergic networks. The associations of mismatch negativity impairments with increased severity of schizophrenia-like negative symptoms and poorer executive functions performance in our 22q11.2DS sample suggest that mismatch negativity is a potential endophenotype for schizophrenia in 22q11.2DS. 相似文献
127.
Aydin Gulses Altan Varol Yavuz Sinan Aydintug Ramazan Koymen Omer Gunhan 《Oral and maxillofacial surgery》2013,17(1):67-71
Background
The aim of this current report is to present an unusual case of a maxillary ameloblastoma mimicking an oroantral fistula.Case report
A left subtotal maxillectomy via Weber–Ferguson-type incision was performed. The patient tolerated the procedure well, the postoperative course was uneventful, and the patient was discharged 3 days after surgery with a mild paraesthesia of the right infraorbital nerve distribution. The infraorbital nerve paraesthesia has resolved 5 months after resection. The patient has been followed-up for 3 years without recurrence.Discussion
Ameloblastoma is a well-known pathology of the maxillofacial region. However, unusual manifestations of this tumor can represent a serious challenge for diagnosis. 相似文献128.
129.
Nurit Omer MD Nir Giladi MD Tanya Gurevich MD Anat Bar-Shira PhD Mali Gana-Weisz PhD Tal Glinka MSc Orly Goldstein PhD Meir Kestenbaum MD Jesse M. Cedarbaum MD Omar S. Mabrouk PhD Kyle B. Fraser PhD Julia C. Shirvan MD PhD Avi Orr-Urtreger MD PhD Anat Mirelman PhD Avner Thaler MD PhD 《Movement disorders》2022,37(1):190-195
130.
Ebru Gok Oguz Guner Karaveli Gursoy Ozlem Yayar Tolga Yildirim Tolga Cimen Cengiz Bulut 《Renal failure》2016,38(8):1180-1186
Introduction: Left ventricular hypertrophy (LVH) is one of the most common cardiac abnormalities in patients with end stage renal disease (ESRD). Hypertension, diabetes, increased body mass index, gender, age, anemia, and hyperparathyroidism have been described as risk factors for LVH in patients on dialysis. However, there may be other risk factors which have not been described yet. Recent studies show that renalase is associated with cardiovascular events. The aim of this study was to reveal the relation between renalase, LVH in patients under hemodialysis (HD) treatment.Methods: The study included 50?HD patients and 35 healthy controls. Serum renalase levels and left ventricle mass index (LVMI) were measured in all participants and the relation between these variables was examined.Findings: LVMI was positively correlated with dialysis vintage and C-reactive protein (CRP) (r?=?0.387, p?=?0.005 and r?=?0.597, p?0.001, respectively) and was negatively correlated with residual diuresis and hemoglobin levels (r?=??0.324, p?=?0.022 and r?=??0.499, p?0.001, respectively). There was no significant association of renalase with LVMI in the HD patients (r?=?0.263, p?=?0.065). Serum renalase levels were significantly higher in HD patients (212?±?127?ng/mL) compared to controls (116?±?67?ng/mL) (p?0.001). Renalase was positively correlated with serum creatinine and dialysis vintage (r?=?0.677, p?0.001 and r?=?0.625, p?0.001, respectively).Discussion: In our study, LVMI was correlated with dialysis vintage, residual diuresis, CRP, and hemoglobin. LVMI tends to correlate with renalase and this correlation may be significant in studies with more patient numbers. The main parameters affecting renalase levels are dialysis vintage and serum creatinine. 相似文献