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991.
We have studied the effect of the aluminum complex of sucrose sulphate (Sucralfate suspension) and the sodium salt of sucrose sulphate (sodium sucrose sulphate solution) on patients with keratoconjunctivitis sicca. Eyes treated with either of these two drugs showed a decrease in painfulness and blurring of vision. On examination the surface area of the corneal lesions, stained with fluorescein, diminished during treatment. As for the difference in effect between the two eyedrops, the solution was better tolerated. 相似文献
992.
Elevated body temperature restricts growth of Haemophilus influenzae type b during experimental meningitis. 下载免费PDF全文
Elevation of the environmental temperature appeared to counteract the temperature-depressing effects of urethane anesthetic and allowed rabbits intracisternally infected with Haemophilus influenzae type b to mimic the development of a fever following infection. Elevated core body temperature (greater than 39 degrees C) was associated with an inhibition of the growth of H. influenzae in cerebrospinal fluid (CSF) during the first 12 h postinfection, whereas bacterial growth was essentially unrestricted in rabbits with reduced (approximately 37 degrees C) body temperature. Bacterial densities 24 h postinfection were different, hyperthermic animals having log 6.0 +/- 0.4 CFU/ml of CSF and hypothermic rabbits having log 8.2 +/- 0.8 CFU/ml of CSF (P less than 0.05, Wilcoxon rank sum test). However, the growth of this bacterium in vitro, in either pooled rabbit CSF or brain heart infusion broth, was not inhibited at 39 degrees C. These results suggest that elevated body temperature associated with the development of fever during meningitis may be associated with restriction of the growth of H. influenzae in vivo but that this effect is apparently not due to an innate inability of the bacterium to grow at elevated temperatures. 相似文献
993.
E. G. Redchits A. S. Parfenov G. R. Rudenko E. E. Sokolovskii V. O. Guzeva I. E. Semavin 《Bulletin of experimental biology and medicine》1992,113(5):656-658
Research Institute of Physicochemical Medicine, Ministry of Health, Moscow. (Presented by Academician of the Academy of Medical Sciences Yu. M. Lopukhin.) Translated from Byulleten Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 5, pp. 488–489, May, 1992. 相似文献
994.
995.
I I Balabolkin L M Karsybekova G B Gershman P L Shcherbakov N N Terekhina V O Bokser V A Reviakina I V Gmoshinski? 《Pediatriia》1991,(1):38-42
Children with food allergy underwent allergologic and gastroenterologic examinations using esophagogastroduodenojejunoscopy. Impairment of the jejunum in the form of jejunitis associated with function abnormality as shown by the loading tests was revealed. It is concluded that the given patients: group should be examined for the morphofunctional status of the upper gastrointestinal tract. 相似文献
996.
Pharmacokinetics and pharmacokinetic-dynamic modelling of rocuronium in infants and children 总被引:1,自引:0,他引:1
Wierda JMKM.; Meretoja O. A.; Taivainen T.; Proost J. H. 《British journal of anaesthesia》1997,78(6):690-695
We have determined the pharmacokinetics and pharmacokinetic-
pharmacodynamic relationship of rocuronium in infants and children. We
studied infants (n = 5, 0.1-0.8 yr) and children (n = 5, 2.3-8 yr), ASA II,
in the ICU while undergoing artificial ventilation under i.v. anaesthesia
with an arterial cannula in situ and the EMG of the adductor pollicis
muscle was monitored. Rocuronium 0.06 (infants) and 0.09 (children) mg kg-1
min-1 was given i.v. over +/- 5 min until 85% neuromuscular block was
obtained. Arterial blood samples were obtained over 240 min. Plasma
concentrations were measured by HPLC. Pharmacokinetic-dynamic variables
were calculated using the Sheiner model and the Hill equation. Statistical
analysis was performed using the Mann-Whitney U test (P < 0.05). The
mean administered dose was 0.32 (SD 0.08) mg kg-1 and 0.4 (0.1) mg kg-1 for
infants and children, respectively. Infants differed from children in
plasma clearance (4.2 (0.4) vs 6.7 (1.1) ml min-1 kg-1), distribution
volume at steady state (231 (32) vs 165 (44) ml kg-1), mean residence time
(56 (10) vs 26 (9) min), concentration in the effect compartment at 50%
block (1.2 (0.4) vs 1.7 (0.4) mg litre-1) and the slope of the
concentration-effect relationship (5.7 (1.3) vs 3.9 (0.5)). Calculated mean
ED90 values were 0.26 and 0.34 mg kg-1 for infants and children,
respectively. The time course of neuromuscular block after equipotent doses
did not differ.
相似文献
997.
The complement system in human reproduction. 总被引:3,自引:0,他引:3
O A Vanderpuye C A Labarrere J A McIntyre 《American journal of reproductive immunology (New York, N.Y. : 1989)》1992,27(3-4):145-155
Regulation of the complement system in reproduction is unique inasmuch as reproductive tissues represent the only condition where allogeneic interactions occur naturally. Both allogeneic extraembryonic membranes and semen that contact and interact with maternal cells and tissues must avert complement-mediated damage to ensure reproductive success. Several regulators of complement activation exist. Membrane cofactor protein (MCP) and decay accelerating factor (DAF) inactivate C3 and C5 convertases on cell surfaces. In addition, CD59 inhibits the membrane attack complex (MAC) of the complement cascade. Strong expression of these membrane glycoproteins by trophoblast and amniotic epithelium has been observed. MCP, DAF, and CD59 likely safeguard extraembryonic tissues from complement damage originating from maternal and fetal blood or amniotic fluid. Different reproductive tract fluids vary in complement levels. With the exception of ovarian follicular fluid, these levels are generally much less than those in blood. Endometrial and cervical content of C3 appear to be regulated by hormones. These observations suggest that the effects of complement activation may vary in reproductive tissues. MCP is absent from the surfaces of oocytes. Sperm express MCP and DAF in discrete areas that would not be associated with the known complement-regulatory functions of these proteins. Seminal plasma contains MCP and the MAC inhibitor SP-40,40 but not DAF.SP-40,40 may exemplify how complement-regulatory proteins perform alternative functions as it interacts with molecules other than complement components. We have reviewed aspects of the complement system that relate to allogeneic interactions in reproduction and that suggest fruitful areas for further research. 相似文献
998.
Summary. Divers have worked at 500 m depth in the sea and have reached 700 m in simulated chamber dives. A prerequisite for this has been extensive physiological studies of the body's reactions to pressure and pressure changes. This paper reviews such physiological and pathophysiological studies with emphasis on recent developments. 相似文献
999.
1000.
W D Haire R P Lieberman G B Lund J A Edney A Kessinger J O Armitage 《Bone marrow transplantation》1991,7(1):57-59
Thrombosis is common after placement of silicone rubber subclavian vein catheters in patients with malignancy receiving conventional doses of chemotherapy. To determine the incidence of this complication in marrow transplant patients and the effect of different catheter designs on thrombosis rates, patients were randomized to receive either open-ended Hickman catheters or valve-ended Groshong catheters for venous access during the transplantation procedure. A total of 35 catheters were placed, of which 23 were double-lumen (11 Groshong and 12 Hickman) and 12 were single-lumen (six Groshong and six Hickman). Arm venograms were performed on all patients at the time of hematopoietic recovery or occurrence of symptoms of subclavian vein thrombosis. There were 10 cases of total subclavian vein thrombosis (three were symptomatic) and 12 cases of asymptomatic non-occlusive mural thrombi. Only 13 normal veins were found. There was no difference in thrombosis rate between the Hickman and Groshong catheters. Double lumen catheters tended to be more likely to cause total venous occlusion (nine of 23) than single lumen catheters (one of 12) (p = 0.06, Fisher's exact test). We conclude that subclavian vein thrombosis is a common occurrence after placement of silicone rubber catheters for venous access during marrow transplantation. Most cases are asymptomatic. Groshong catheters are just as likely to cause this complication as Hickman catheters. 相似文献