全文获取类型
收费全文 | 662篇 |
免费 | 23篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 54篇 |
妇产科学 | 29篇 |
基础医学 | 72篇 |
口腔科学 | 43篇 |
临床医学 | 44篇 |
内科学 | 100篇 |
皮肤病学 | 7篇 |
神经病学 | 52篇 |
特种医学 | 24篇 |
外科学 | 79篇 |
综合类 | 7篇 |
预防医学 | 22篇 |
眼科学 | 43篇 |
药学 | 46篇 |
中国医学 | 8篇 |
肿瘤学 | 40篇 |
出版年
2023年 | 7篇 |
2022年 | 10篇 |
2021年 | 11篇 |
2020年 | 13篇 |
2019年 | 9篇 |
2018年 | 22篇 |
2017年 | 6篇 |
2016年 | 18篇 |
2015年 | 17篇 |
2014年 | 26篇 |
2013年 | 33篇 |
2012年 | 52篇 |
2011年 | 39篇 |
2010年 | 18篇 |
2009年 | 17篇 |
2008年 | 46篇 |
2007年 | 51篇 |
2006年 | 44篇 |
2005年 | 44篇 |
2004年 | 49篇 |
2003年 | 35篇 |
2002年 | 30篇 |
2001年 | 8篇 |
2000年 | 5篇 |
1999年 | 5篇 |
1998年 | 2篇 |
1996年 | 4篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1992年 | 4篇 |
1991年 | 9篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1987年 | 4篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 1篇 |
1983年 | 3篇 |
1982年 | 3篇 |
1981年 | 1篇 |
1978年 | 1篇 |
1976年 | 1篇 |
1972年 | 1篇 |
1971年 | 4篇 |
1969年 | 3篇 |
1968年 | 4篇 |
1967年 | 6篇 |
1966年 | 5篇 |
1965年 | 1篇 |
1888年 | 1篇 |
排序方式: 共有687条查询结果,搜索用时 15 毫秒
71.
Candan C Sever L Civilibal M Caliskan S Arisoy N 《Pediatric nephrology (Berlin, Germany)》2009,24(3):581-587
The aim of this study was to adjust dry weight by short-term blood volume monitoring (BVM)-guided ultrafiltration and evaluate
the effects of optimizing dry weight on blood pressure (BP) control and intradialytic symptoms (IDS) in a group of hypertensive
hemodialysis (HD) patients. The study was performed in four sequential phases, each of which lasted for 1 week, on nine hypertensive
HD patients (six girls, age 16.9 ± 3.1 years). In phase I, patients were observed by BVM. In phase II, BVM was used to guide
ultrafiltration to adjust dry weight. Antihypertensive drugs were gradually tapered or withheld in phase III, when the patients
were hypotensive and/or their IDS increased. In phase IV, this particular weight was maintained without any intervention.
Pre- and post-HD body weight, pre-HD, post-HD, 30 min after HD casual BP values, and IDS in each HD session were recorded.
The BP was also assessed by 44-h ambulatory BP monitoring (ABPM), which is an ideal method to determine BP changes throughout
the interdialytic period at the beginning of phase I and at the end of phase IV. There was a decrease in mean dry weight,
all casual systolic BPs, and systolic/diastolic ABPM at the end of the study (all p ≤ 0.05). Antihypertensive drugs were stopped in five patients and reduced in two during phase III of the study. The IDS was
more frequent (36%) in phase IV than in phase I (16%); however, this increase did not reach statistical significance. The
results of this study suggest that short-term BVM guided-ultrafiltration may be a useful tool to diagnose volume overload
and to adjust dry weight and, consequently, to achieve a better control of BP in pediatric HD patients. 相似文献
72.
Ertan AA Celebi N Bayolken M Onur MA Aboushelib MN Feilzer A Cehreli M 《Journal of biomedical materials research. Part B, Applied biomaterials》2009,88(1):182-190
The purpose of this study was to explore the effects of airborne-particle abrasion and selective infiltration etching of a yttrium-partially stabilized tetragonal zirconia polycrystal (Y-TZP) implant surfaces on nerve conduction. Particle-abraded Y-TZP (P/Y-TZP), selective infiltration etched Y-TZP (SIE/Y-TZP), and commercially pure titanium (CP-Ti) were used in the study (n = 5).The compound action potentials of the right and left sciatic nerves of eight sacrificed rats were quantified at the in vitro level. The implants were brought into intimate contact with the nerves and the time required for initiation of compound action potentials (TcAP), depolarization (Dp), repolarization (Rp), and amplitude of evoked compound action potentials (cAPs) were recorded before and after contact with the implants. The difference in cAPs between the basal response and after contact with CP-Ti implant was significant (p < 0.05). Time-dependent changes in cAPs of P/Y-TZP and SIE/Y-TZP groups and their basal nerve responses were similar (p > 0.05). Within- and between-subject comparisons revealed that TcAP, Dp, and Rp values for all groups were similar (p > 0.05). Particle-abraded and selective infiltration-etched zirconia implant surfaces do not alter nerve conduction beyond physiologic limits. 相似文献
73.
We report a 53-year-old male patient who underwent paravertebral mass excision at the D10-11-12 vertebral levels in 2007. The histopathological evaluation of the mass showed the presence of neuroblastoma. The patient was diagnosed with stage IV neuroblastoma. He received 6 courses of chemotherapy and exhibited a stable course until March 2010. When he was reevaluated in March 2010, progression in the metastatic lesion as well as local recurrence was detected. The patient, who was restarted on chemotherapy, developed progressive weakness and loss of sensation of the lower extremity. The neurosurgical investigation revealed an irreversible loss in motor functions. The patient is currently on symptomatic treatment. 相似文献
74.
Selcukbiricik F Tural D Bay A Sahingoz G Ilvan S Mandel NM 《Case reports in oncology》2011,4(3):521-525
A 37-year-old woman presented to the Internal Medicine Clinic with complaints of abdominal pain and constipation which had begun 3 months earlier. A colonoscopy was performed, and wall thickening of the sigmoid colon was detected. A biopsy of the sigmoid colon revealed a poorly differentiated, mucin-producing adenocarcinoma with a signet-ring pattern. No distant metastasis was detected. The patient was treated with chemotherapy consisting of 5-fluorouracil, leucovorin, and oxaliplatin. One and a half years later, a painless mass, which was not fixed to the skin, measuring 1 cm in diameter, was found in the lower outer quadrant of the left breast. A core biopsy of the mass was performed, and a histopathological report confirmed metastasis to the breast from mucinous adenocarcinoma of an intestinal primary. 相似文献
75.
M. Aylin Akgun Arıcı Sule KalkanOmer Demir Nil Hocaoglu AksaySedef Gidener Yesim Tuncok 《Toxicology letters》2009
Aims
To investigate the role of beta receptor blockade via adenosine A1 receptor stimulation on amitriptyline-induced QRS prolongation.Methods
Isolated rat hearts were randomized into three groups (n = 8 for each group). After pretreatment with 5% dextrose (control) or DPCPX (8-cyclopentyl-1,3-dipropylxanthine), or propranolol + DPCPX, amitriptyline infusion was given to all groups. Intact beta adrenergic receptor response was verified with a bolus dose of isoproteranol (3 × 10−5 M).Results
Amitriptyline (5.5 × 10−5 M) infusion following pretreatment with 5% dextrose or 10−4 M DPCPX prolonged QRS by 40–110% and 30–75%, respectively. After the beta receptor blockade with 10−2 M propranolol bolus, amitriptyline infusion following pretreatment with DPCPX prolonged QRS by 40–130%. Amitriptyline infusion following pretreatment with DPCPX (10−4 M) shortened the QRS at 40, 50 and 60 min significantly when compared to propranolol + DPCPX group (168.8 ± 4.9%, p < 0.05; 170.8 ± 6.9%, p < 0.01; 174.0 ± 6.9%, p < 0.01, respectively). Amitriptyline infusion following pretreatment with 5% dextrose prolonged QRS duration significantly at 50th minutes (209.5 ± 6.1%, p < 0.05) compared to DPCPX pretreatment group.Conclusion
DPCPX pretreatment shortened amitriptyline-induced QRS prolongation. Beta adrenergic receptor blockade enhanced QRS prolongation shortened by DPCPX pretreatment. Adenosine A1 receptor stimulation related to beta adrenergic receptor blockade may play a role in amitriptyline-induced QRS prolongation in isolated rat hearts. 相似文献76.
Onak-Kandemir N Ege-Gül A Karadayi N 《Acta orthopaedica et traumatologica turcica》2008,42(2):145-147
Calcified aponeurotic fibroma is a rare benign fibrous tumor with well-characterized histopathologic features. It is usually seen in distal extremities of children and youngsters. A 23-year-old male patient underwent surgical excision of a free, painless soft tissue mass that developed in the palmar aspect of the left hand. Histopathologic examination showed fibroblastic proliferation areas and dense collagenous stroma surrounding calcifications and chondroid metaplasia. The diagnosis was made as calcified aponeurotic fibroma. No recurrences were detected within a year follow-up. 相似文献
77.
Hepatoblastoma is a rare neoplasm of all pediatric cancers. The goal of treatment is to remove the tumor completely because cure without complete resection is extremely unusual. Accurate assessment of tumor resectability following preoperative chemotherapy is of crucial importance. It is sometimes difficult, especially when the tumor is as large and calcified as in the described case. Detailed radiological imaging such as computed tomography angiography or magnetic resonance angiography is the key for selecting the proper treatment method in hepatoblastoma during the preoperative period. In this article, we report a successfully treated giant calcified hepatoblastoma despite radiological assessment complexity. 相似文献
78.
79.
80.
Depression, automatic thoughts, alexithymia, and assertiveness in patients with tension-type headache 总被引:1,自引:0,他引:1
OBJECTIVE: The role of psychological factors related to headache has long been a focus of investigation. The aim of this study was to evaluate depression, automatic thoughts, alexithymia, and assertiveness in persons with tension-type headache and to compare the results with those from healthy controls. METHODS: One hundred five subjects with tension-type headache (according to the criteria of the International Headache Society classification) and 70 controls were studied. The Beck Depression Inventory, Automatic Thoughts Scale, Toronto Alexithymia Scale, and Rathus Assertiveness Schedule were administered to both groups. Sociodemographic variables and headache features were evaluated via a semistructured scale. RESULTS: Compared with healthy controls, the subjects with headache had significantly higher scores on measures of depression, automatic thoughts, and alexithymia and lower scores on assertiveness. Subjects with chronic tension-type headache had higher depression and automatic thoughts scores than those with episodic tension-type headache. CONCLUSIONS: These findings suggested that persons with tension-type headache have high depression scores and also may have difficulty with expression of their emotions. Headache frequency appears to influence the likelihood of coexisting depression. 相似文献