全文获取类型
收费全文 | 1941篇 |
免费 | 91篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 168篇 |
妇产科学 | 106篇 |
基础医学 | 206篇 |
口腔科学 | 75篇 |
临床医学 | 180篇 |
内科学 | 435篇 |
皮肤病学 | 78篇 |
神经病学 | 138篇 |
特种医学 | 32篇 |
外科学 | 284篇 |
综合类 | 36篇 |
预防医学 | 57篇 |
眼科学 | 50篇 |
药学 | 69篇 |
中国医学 | 1篇 |
肿瘤学 | 76篇 |
出版年
2024年 | 1篇 |
2023年 | 25篇 |
2022年 | 27篇 |
2021年 | 65篇 |
2020年 | 41篇 |
2019年 | 59篇 |
2018年 | 56篇 |
2017年 | 47篇 |
2016年 | 63篇 |
2015年 | 67篇 |
2014年 | 95篇 |
2013年 | 100篇 |
2012年 | 156篇 |
2011年 | 155篇 |
2010年 | 92篇 |
2009年 | 78篇 |
2008年 | 136篇 |
2007年 | 128篇 |
2006年 | 124篇 |
2005年 | 117篇 |
2004年 | 94篇 |
2003年 | 70篇 |
2002年 | 63篇 |
2001年 | 30篇 |
2000年 | 24篇 |
1999年 | 23篇 |
1998年 | 13篇 |
1997年 | 10篇 |
1996年 | 6篇 |
1995年 | 6篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1992年 | 10篇 |
1991年 | 5篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1986年 | 1篇 |
1984年 | 8篇 |
1983年 | 5篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 4篇 |
1978年 | 1篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1972年 | 2篇 |
1970年 | 1篇 |
排序方式: 共有2033条查询结果,搜索用时 15 毫秒
21.
22.
23.
Kaptan Yagmur Suner Asli Taş Mehmet Nedim Oksel Fahrettin Aksu Kenan Sayiner Abdullah 《Clinical rheumatology》2021,40(9):3783-3788
Clinical Rheumatology - Although latent tuberculosis infection (LTBI) treatment is given before anti-tumor necrosis factor (TNF) treatment, tuberculosis (TB) still develops in these patients and... 相似文献
24.
The protective effect of severe mitral regurgitation (MR) against left atrial thrombus formation has been well documented. It was also proposed that severe MR may prevent thrombus formation within the left ventricle (LV) with systolic dysfunction. Therefore, we investigated whether ischemic MR prevents thrombus formation within the LV in patients with systolic dysfunction. The study population was comprised of 1313 patients (1133 males, 180 females, age 56+/-18) with ischaemic LV dysfunction documented by coronary angiography and left ventriculography. None of the patients had a history of chronic anticoagulation. Epicardial coronary arteries were normal in 91 patients, and single-vessel, two-vessel, and triple-vessel disease were detected in 328, 330, and 564 patients, respectively. Left ventricular thrombus and severe MR were detected in 191 (14.5%) and 125 (9.5%) patients, respectively. Overall incidence of LV thrombus was lower in patients with severe MR than in patients without severe MR (4% vs 15.6%, OR: 0.2, P<0.001). Severe MR compared with absence of severe MR was associated with a lower incidence of LV thrombus both in patients with ischemic dilated cardiomyopathy (6.8% vs 34.2%, OR: 0.19, P<0.001), and in patients with aneurysm (3% vs 18%, OR: 0.14, P<0.0001) involving anterolateral, septal and/or apical LV segments. A similar trend without statistical significance was also observed in patients with dyskinesia (4.7% vs 16%, OR: 0.26, P=0.1) related to anterolateral, septal and/or apical LV segments. However, MR had no impact on the incidence of LV thrombus in patients with aneurysm or dyskinesia related to posterior and/or inferior segments (3.7% vs 3%, OR: 1.2, P>0.05). In conclusion, severe MR seems to prevent LV mural thrombus formation in patients with ischemic dilated cardiomyopathy, and in patients with aneurysm related to anterolateral, septal, and/or apical LV segments. This relative risk reduction may be associated with diastolic volume overloading due to severe MR which may overcome stagnation and a procoagulant state within the LV with severe systolic dysfunction. 相似文献
25.
Kaela Drzewiecki Jungmin Choi Joseph Brancale Michael A. Leney-Greene Sinan Sari Buket Dalgi Aysel Ünlüsoy Aksu Gülseren Evirgen ahin Ahmet Ozen Safa Baris Elif Karakoc-Aydiner Dhanpat Jain David Kleiner Michael Schmalz Kadakkal Radhakrishnan Junhui Zhang Kasper Hoebe Helen C. Su Joo P. Pereira Michael J. Lenardo Richard P. Lifton Sílvia Vilarinho 《The Journal of experimental medicine》2021,218(7)
26.
Nihal Buzkan Bülent B. Arpaci Vincent Simon Hatem Fakhfakh Benoît Moury 《Archives of virology》2013,158(4):881-885
Open-field pepper crops were sampled in 2011 in Turkey and Tunisia and surveyed for the major pepper-infecting viruses. As expected, potato virus Y and cucumber mosaic virus (in both countries), and tobacco etch virus (in Turkey only) were quite frequent. However, poleroviruses were the most common viruses, with prevalences above 70 %. Partial sequence analyses revealed the occurrence of poleroviruses resembling either beet western yellows virus (BWYV) or pepper vein yellows virus in the sampled areas, with BWYV being predominant in Turkey but in the minority in Tunisia. Poleroviruses should therefore be taken into account in disease control of pepper crops in the Mediterranean area. 相似文献
27.
Kocagoz Tanil Can Ozge Yurttutan Uyar Neval Aksoy Ece Polat Tuba Cankaya Dilara Karakus Betul Mozioglu Erkan Kocagoz Sesin 《European journal of clinical microbiology & infectious diseases》2021,40(12):2617-2622
European Journal of Clinical Microbiology & Infectious Diseases - Since its emergence in December 2019, SARS-CoV-2 is causing one of the most devastating pandemics in human history. Currently,... 相似文献
28.
29.
Radiotherapy (XRT) is a curative treatment option for prostate cancer (PCa). Recent XRT technologies allow higher dose therapy that lead to increased local control with less adjacent tissue damage. Additionally, receiving neo-adjuvant or adjuvant hormonotherapy (HT) during radiation therapy increases the curative effect. The aim of this paper is to review the current literature and guidelines on external beam radiation therapy for PCa. However, brachytherapy and radiosurgery, a recently evolving relatively new technology for the radiotherapeutic management of localized PCa, are beyond the scope of this paper. 相似文献
30.
Ömer Nuri Pamuk Umut Kalyoncu Kenan Aksu Ahmet Omma Yavuz Pehlivan Yonca Çağatay Orhan Küçükşahin Salim Dönmez Gözde Yıldırım Çetin Rıdvan Mercan Özün Bayındır Ayşe Çefle Fatih Yıldız Ayşe Balkarlı Levent Kılıç Necati Çakır Bünyamin Kısacık Mustafa Ferhat Öksüz Veli Çobankara Ahmet Mesut Onat Mehmet Sayarlıoğlu Mehmet Akif Öztürk Gülsüm Emel Pamuk Nurullah Akkoç 《Rheumatology international》2016,36(7):945-953
In this multicenter, retrospective study, we evaluated the efficacy and safety of biologic therapies, including anti-TNFs, in secondary (AA) amyloidosis patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA). In addition, the frequency of secondary amyloidosis in RA and AS patients in a single center was estimated. Fifty-one AS (39M, 12F, mean age: 46.7) and 30 RA patients (11M, 19F, mean age: 51.7) with AA amyloidosis from 16 different centers in Turkey were included. Clinical and demographical features of patients were obtained from medical charts. A composite response index (CRI) to biologic therapy—based on creatinine level, proteinuria and disease activity—was used to evaluate the efficacy of treatment. The mean annual incidence of AA amyloidosis in RA and AS patients was 0.23 and 0.42/1000 patients/year, respectively. The point prevalence in RA and AS groups was 4.59 and 7.58/1000, respectively. In RA group with AA amyloidosis, effective response was obtained in 52.2 % of patients according to CRI. RA patients with RF positivity and more initial disease activity tended to have higher response rates to therapy (p values, 0.069 and 0.056). After biologic therapy (median 17 months), two RA patients died and two developed tuberculosis. In AS group, 45.7 % of patients fulfilled the criteria of good response according to CRI. AS patients with higher CRP levels at the time of AA diagnosis and at the beginning of anti-TNF therapy had higher response rates (p values, 0.011 and 0.017). During follow-up after anti-TNF therapy (median 38 months), one patient died and tuberculosis developed in two patients. Biologic therapy seems to be effective in at least half of RA and AS patients with AA amyloidosis. Tuberculosis was the most important safety concern. 相似文献