全文获取类型
收费全文 | 206257篇 |
免费 | 8382篇 |
国内免费 | 540篇 |
专业分类
耳鼻咽喉 | 2675篇 |
儿科学 | 5856篇 |
妇产科学 | 4944篇 |
基础医学 | 29233篇 |
口腔科学 | 6453篇 |
临床医学 | 12696篇 |
内科学 | 46654篇 |
皮肤病学 | 5426篇 |
神经病学 | 17041篇 |
特种医学 | 5682篇 |
外国民族医学 | 7篇 |
外科学 | 24115篇 |
综合类 | 1056篇 |
一般理论 | 38篇 |
预防医学 | 23248篇 |
眼科学 | 5003篇 |
药学 | 15564篇 |
中国医学 | 792篇 |
肿瘤学 | 8696篇 |
出版年
2023年 | 1065篇 |
2022年 | 1353篇 |
2021年 | 3873篇 |
2020年 | 2101篇 |
2019年 | 3860篇 |
2018年 | 7452篇 |
2017年 | 4601篇 |
2016年 | 3984篇 |
2015年 | 4278篇 |
2014年 | 5207篇 |
2013年 | 7619篇 |
2012年 | 12438篇 |
2011年 | 13106篇 |
2010年 | 6836篇 |
2009年 | 5325篇 |
2008年 | 10808篇 |
2007年 | 11426篇 |
2006年 | 10859篇 |
2005年 | 10542篇 |
2004年 | 9841篇 |
2003年 | 9223篇 |
2002年 | 8766篇 |
2001年 | 5890篇 |
2000年 | 6514篇 |
1999年 | 5032篇 |
1998年 | 1171篇 |
1992年 | 2713篇 |
1991年 | 2369篇 |
1990年 | 2382篇 |
1989年 | 2032篇 |
1988年 | 1925篇 |
1987年 | 1807篇 |
1986年 | 1821篇 |
1985年 | 1680篇 |
1984年 | 1210篇 |
1983年 | 1037篇 |
1979年 | 1332篇 |
1978年 | 913篇 |
1977年 | 880篇 |
1976年 | 830篇 |
1975年 | 989篇 |
1974年 | 1220篇 |
1973年 | 1277篇 |
1972年 | 1205篇 |
1971年 | 1171篇 |
1970年 | 1097篇 |
1969年 | 1165篇 |
1968年 | 1194篇 |
1967年 | 1069篇 |
1966年 | 942篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
121.
122.
123.
124.
Laureano Fernández-Cruz Rebeca Cosa Laia Blanco Sammy Levi Miguel-Angel López-Boado Salvador Navarro 《Journal of gastrointestinal surgery》2007,11(12):1607-1622
Laparoscopic pancreatic surgery (LPS) has seen significant development but much of the knowledge refers to small and benign
pancreatic tumors. This study aims to evaluate the feasibility, safety, and long-term outcome of the laparoscopic approach
in patients with benign, premalignant, and overt malignant lesions of the pancreas. This study, currently, is the largest
single center experience worldwide. One hundred twenty-three consecutive patients underwent laparoscopic pancreatic surgery
from April 1998 to April 2007, 20 patients with cysts or pseudocysts for acute and chronic pancreatitis, laparoscopic pancreatic
drainage was performed, and were excluded from the analysis. The 103 patients were divided based on preoperative diagnosis:
group I, inflammatory tumors for chronic pancreatitis (eight patients); group II, cystic pancreatic neoplasms (29 patients);
group III, intraductal papillary mucinous neoplasms (10 patients); group IV, neuroendocrine pancreatic tumors (NETs) (43 patients);
and group V ductal adenocarcinoma (13 patients). The median tumor size was 5.3 cm. Pathologic data include R
0 or R
1 resection (transection margins on the specimen were inked). Perioperative data, postoperative complications, and resection
modalities were compared using statistical analysis. Long-term outcomes were analysed by tumor recurrence and patient survival.
The overall conversion rate was 7%. Laparoscopic distal pancreatic resection was performed in 82 patients (79.6%). Laparoscopic
spleen-preserving distal pancreatectomy (Lap SPDP) was performed in 52 patients (63.7%), but with splenic vessels preservation
in 22% and without splenic vessels preservation in 41.5%. Laparoscopic en-bloc splenopancreatectomy (Lap SxDP) was performed
in 30 patients (36.6%) and laparoscopic enucleation (Lap En) in 20 patients (19.4%). There was no mortality. The overall complication
rate was 25.2, 16.7, and 40% after Lap SPDP, Lap SxDP, and Lap En, respectively. The overall morbidity rate was significantly
higher (p > 0.05) in the group of Lap SPDP without splenic vessels preservation comparing with Lap SPDP with splenic vessels preservation
because of the occurrence of splenic complications (20.6%). The overall pancreatic fistulas was 7.7, 10, and 35% after Lap
SPDP, Lap SxDP, and Lap En, respectively; the severity of fistula was significantly higher in the Lap En group (p > 0.05). The mean hospital stay was within 1 week in all groups, except in the group of ductal adenocarcinoma, which is 8 days.
In this series, 27 patients (26.2%) had malignant disease. R
0 resection was achieved in 90% of ductal adenocarcinoma and 100% for other malignant tumors. The median survival for ductal
adenocarcinoma patients was 14 months. This series demonstrates that LPS is feasible and safe in benign-appearing and malignant
lesions of the pancreas. 相似文献
125.
126.
L Crespo J Graus F García-Hoz R Bárcena L Gil Grande V F Moreira J M Milicua J Sánchez J Blázquez 《Revista española de enfermedades digestivas》2007,99(11):667-670
Hepatic encephalopathy is a reversible state of altered cognition that may occur in patients with acute or chronic liver disease or porto-systemic shunt, and in which known neurological or psychiatric signs may develop. Nitrogenated substances from intestinal digestion reach the brain without being cleared by their passage through the liver due to the presence of porto-systemic shunt. We report two cases of patients with porto-systemic shunt diagnosed with recurrent chronic hepatic encephalopathy refractory to conventional medical treatment. They were satisfactorily treated with shunt embolization using interventionist radiology techniques. 相似文献
127.
128.
Moisés A Arriaga Douglas A Chen Kathleen A Cenci 《Otolaryngology--head and neck surgery》2005,133(3):329-333
OBJECTIVES: To compare the sensitivity of rotational chair (ROTO) versus electronystagmography (ENG) in peripheral vestibular pathology. METHODS: Retrospective chart review. RESULTS: One thousand consecutive patients undergoing evaluation for dizziness and imbalance at a tertiary care referral balance center were reviewed. ROTO was the primary vestibular study used in all patients with ENG used as a confirmatory test at the discretion of the treating physician. A subgroup of 478 patients underwent both ROTO and ENG. Among the patients diagnosed with peripheral vestibulopathy, sensitivity for peripheral vestibulopathy was 71% for ROTO and 31% for ENG. However, specificity was 54% for ROTO and 86% for ENG. CONCLUSIONS: We conclude that in this retrospective cohort with the authors' clinical diagnoses, ROTO is a more sensitive diagnostic study of peripheral vestibular pathology. The higher sensitivity of ROTO and the higher specificity of ENG may support the use of ROTO as the primary vestibular study and ENG as a supplemental vestibular study. Prospective analysis with distinct diagnostic criteria and defined inclusion criteria are necessary before these results can be widely extrapolated. 相似文献
129.
Javier Garzón Almudena López-Fando Pilar Sánchez-Blázquez 《Neuropsychopharmacology》2003,28(11):1983-1990
Members of the R7 subfamily of regulators of G-protein signaling (RGS) proteins (RGS6, RGS7, RGS9-2, and RGS11) are found in the mouse CNS. The expression of these proteins was effectively reduced in different neural structures by blocking their mRNA with antisense oligodeoxynucleotides (ODNs). This was achieved without noticeable changes in the binding characteristics of labeled beta-endorphin to opioid receptors. Knockdown of R7 proteins enhanced the potency of antinociception promoted by morphine and [D-Ala(2), N-MePhe(4), Gly-ol(5)]-enkephalin (DAMGO)-both agonists at mu-opioid receptors. The duration of morphine analgesia was greatly increased in RGS9-2 and in RGS11 knockdown mice. The impairment of R7 proteins brought about different changes in the analgesic activity of selective delta agonists. Knockdown of RGS11 reduced [D-Ala(2)]deltorphin II analgesic effects. Those of RGS6 and RGS9-2 proteins caused [D-Ala(2)]deltorphin II to produce a smoothened time-course curve-the peak effect blunted and analgesia extended during the declining phase. RGS9-2 impairment also promoted a similar pattern of change for [D-Pen(2,5)]-enkephalin (DPDPE). RGS7-deficient mice showed an increased response to both [D-Ala(2)]deltorphin II and DPDPE analgesic effects. A single intracerebroventricular (i.c.v.) ED(80) analgesic dose of morphine gave rise to acute tolerance in control mice, but did not promote tolerance in RGS6, RGS7, RGS9-2, or RGS11 knockdown animals. Thus, R7 proteins play a critical role in agonist tachyphylaxis and acute tolerance at mu-opioid receptors, and show differences in their modulation of delta-opioid receptors. 相似文献
130.