全文获取类型
收费全文 | 957篇 |
免费 | 123篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 60篇 |
儿科学 | 55篇 |
妇产科学 | 17篇 |
基础医学 | 105篇 |
口腔科学 | 33篇 |
临床医学 | 105篇 |
内科学 | 214篇 |
皮肤病学 | 15篇 |
神经病学 | 36篇 |
特种医学 | 42篇 |
外科学 | 220篇 |
综合类 | 17篇 |
一般理论 | 6篇 |
预防医学 | 48篇 |
眼科学 | 10篇 |
药学 | 35篇 |
肿瘤学 | 74篇 |
出版年
2023年 | 8篇 |
2022年 | 18篇 |
2021年 | 36篇 |
2020年 | 21篇 |
2019年 | 31篇 |
2018年 | 38篇 |
2017年 | 35篇 |
2016年 | 24篇 |
2015年 | 27篇 |
2014年 | 30篇 |
2013年 | 31篇 |
2012年 | 40篇 |
2011年 | 48篇 |
2010年 | 38篇 |
2009年 | 34篇 |
2008年 | 49篇 |
2007年 | 47篇 |
2006年 | 39篇 |
2005年 | 21篇 |
2004年 | 31篇 |
2003年 | 18篇 |
2002年 | 15篇 |
2001年 | 14篇 |
2000年 | 14篇 |
1999年 | 16篇 |
1998年 | 18篇 |
1997年 | 14篇 |
1996年 | 19篇 |
1994年 | 14篇 |
1993年 | 11篇 |
1992年 | 15篇 |
1991年 | 16篇 |
1990年 | 9篇 |
1989年 | 18篇 |
1988年 | 7篇 |
1987年 | 12篇 |
1986年 | 15篇 |
1985年 | 17篇 |
1984年 | 16篇 |
1983年 | 14篇 |
1982年 | 10篇 |
1980年 | 12篇 |
1979年 | 12篇 |
1978年 | 13篇 |
1977年 | 9篇 |
1976年 | 6篇 |
1973年 | 12篇 |
1972年 | 18篇 |
1971年 | 8篇 |
1970年 | 7篇 |
排序方式: 共有1092条查询结果,搜索用时 203 毫秒
41.
B G Neel S C Jhanwar R S Chaganti W S Hayward 《Proceedings of the National Academy of Sciences of the United States of America》1982,79(24):7842-7846
We have used in situ chromosome hybridization techniques to map the human cellular counterparts (c-onc genes) of the transforming genes of two RNA tumor viruses on human meiotic pachytene and somatic metaphase chromosomes. We find that the human c-mos gene is located on chromosome 8 at a position corresponding to band 8q22 on the somatic map. The human c-myc gene is found on chromosome 8 at position 8q24. These regions on the long arm of chromosome 8 have been previously reported to be involved in specific translocations found in the M-2 subset of acute nonlymphoblastic leukemias. Burkitt lymphoma, and other forms of non-Hodgkin lymphoma, and a familial abnormality that predisposes to renal cell carcinoma. These results suggest that translocations of the human c-mos or c-myc genes may be causally related to neoplastic transformation. 相似文献
42.
43.
44.
45.
46.
Ensanya Ali Abou Neel Wojciech Chrzanowski Vehid M. Salih Hae-Won Kim Jonathan C. Knowles 《Journal of dentistry》2014
Objectives
of this review is to inform practitioners with the most updated information on tissue engineering and its potential applications in dentistry.Data
The authors used “PUBMED” to find relevant literature written in English and published from the beginning of tissue engineering until today. A combination of keywords was used as the search terms e.g., “tissue engineering”, “approaches”, “strategies” “dentistry”, “dental stem cells”, “dentino-pulp complex”, “guided tissue regeneration”, “whole tooth”, “TMJ”, “condyle”, “salivary glands”, and “oral mucosa”.Sources
Abstracts and full text articles were used to identify causes of craniofacial tissue loss, different approaches for craniofacial reconstructions, how the tissue engineering emerges, different strategies of tissue engineering, biomaterials employed for this purpose, the major attempts to engineer different dental structures, finally challenges and future of tissue engineering in dentistry.Study selection
Only those articles that dealt with the tissue engineering in dentistry were selected.Conclusions
There have been a recent surge in guided tissue engineering methods to manage periodontal diseases beyond the traditional approaches. However, the predictable reconstruction of the innate organisation and function of whole teeth as well as their periodontal structures remains challenging. Despite some limited progress and minor successes, there remain distinct and important challenges in the development of reproducible and clinically safe approaches for oral tissue repair and regeneration. Clearly, there is a convincing body of evidence which confirms the need for this type of treatment, and public health data worldwide indicates a more than adequate patient resource. The future of these therapies involving more biological approaches and the use of dental tissue stem cells is promising and advancing. Also there may be a significant interest of their application and wider potential to treat disorders beyond the craniofacial region.Clinical Significance
Considering the interests of the patients who could possibly be helped by applying stem cell-based therapies should be carefully assessed against current ethical concerns regarding the moral status of the early embryo. 相似文献47.
Waldmann TA; Goldman CK; Bongiovanni KF; Sharrow SO; Davey MP; Cease KB; Greenberg SJ; Longo DL 《Blood》1988,72(5):1805-1816
Human T-cell lymphotropic virus I (HTLV-I)-induced adult T-cell leukemia (ATL) cells constitutively express interleukin-2 (IL-2) receptors identified by the anti-Tac monoclonal antibody (MoAb), whereas normal resting cells do not. This observation provided the scientific basis for a trial of intravenous anti-Tac in the treatment of nine patients with ATL. The patients did not suffer untoward reactions and did not have a reduction in the normal formed elements of the blood, and only one of the nine produced antibodies to the anti-Tac MoAb. Three patients had transient mixed, partial, or complete remissions lasting from 1 to more than 8 months after anti-Tac therapy, as assessed by routine hematologic tests, immunofluorescence analysis of circulating cells, and molecular genetic analysis of HTLV-I provirus integration and of the T-cell receptor gene rearrangement. The precise mechanism of the antitumor effects is unclear; however, the use of a MoAb that prevents the interaction of IL-2 with its receptor on ATL cells provides a rational approach for the treatment of this malignancy. 相似文献
48.
Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: Implications for cell therapy of bone 总被引:25,自引:0,他引:25 下载免费PDF全文
Horwitz EM Gordon PL Koo WK Marx JC Neel MD McNall RY Muul L Hofmann T 《Proceedings of the National Academy of Sciences of the United States of America》2002,99(13):8932-8937
Treatment with isolated allogeneic mesenchymal cells has the potential to enhance the therapeutic effects of conventional bone marrow transplantation in patients with genetic disorders affecting mesenchymal tissues, including bone, cartilage, and muscle. To demonstrate the feasibility of mesenchymal cell therapy and to gain insight into the transplant biology of these cells, we used gene-marked, donor marrow-derived mesenchymal cells to treat six children who had undergone standard bone marrow transplantation for severe osteogenesis imperfecta. Each child received two infusions of the allogeneic cells. Five of six patients showed engraftment in one or more sites, including bone, skin, and marrow stroma, and had an acceleration of growth velocity during the first 6 mo postinfusion. This improvement ranged from 60% to 94% (median, 70%) of the predicted median values for age- and sex-matched unaffected children, compared with 0% to 40% (median, 20%) over the 6 mo immediately preceding the infusions. There was no clinically significant toxicity except for an urticarial rash in one patient just after the second infusion. Failure to detect engraftment of cells expressing the neomycin phosphotransferase marker gene suggested the potential for immune attack against therapeutic cells expressing a foreign protein. Thus, allogeneic mesenchymal cells offer feasible posttransplantation therapy for osteogenesis imperfecta and likely other disorders originating in mesenchymal precursors. 相似文献
49.