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Elmira Ghasemi Narges Pachenari Saeed Semnanian Hossein Azizi 《Developmental psychobiology》2019,61(2):254-260
The number of adolescents who use illicit drugs has increased dramatically. Adolescence is a critical period for brain development and maturation. The importance of the study of pain perception and the possible mechanisms involved is crystal clear. Up until now, there has been no evidence regarding the long-term effect of adolescence morphine administration on pain perception. The objective of the present study was to investigate long-lasting effect of adolescent morphine exposure on pain perception as well as analgesic response to a single dose of morphine injection. Adolescent and adult rats received morphine or saline, and then after 30 days of washout period, formalin test was performed. To evaluate morphine analgesia, in a separate group of animals, formalin test was performed after injection of a single dose of morphine during adulthood. The results demonstrated that the adolescent rats treated by morphine exhibited higher pain-related behaviors compared to the control group, while the same results were not observed in adult rats that had been treated by morphine. Moreover, there was no significant difference in analgesic response to a single dose of morphine between two experimental groups. This study demonstrates enduring effect of morphine exposure during adolescence on pain perception. 相似文献
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In situ electrochemical activation as a new pre-treatment method is extremely effective for enhanced electrocatalytic performances for different applications. With the help of this method, in situ surface modification of electrocatalyst is achieved without using pre-made seeds or complex synthesis procedure. Herein, with the purpose of finding an in situ and simple electrochemical activation protocol, the green synthesis of Au/Pd nanoparticles (AuPd) by means of polyoxometalate (POM) is reported. Structural analysis of the AuPd nanohybrid unveil the Au-core/Pd-shell structure which surrounded by POM. We propose a novel cathodic electrochemical activation in phosphate buffer solution which can greatly boost the electrocatalytic activity of the as-prepared AuPd and Pd electrocatalyst not only for hydrogen evolution reaction (HER) as a model of electro-reduction, but also for methanol and ethanol electro-oxidation reaction (MOR & EOR). For the HER in 1 M NaOH solution, after the electrochemical activation, the needed potential to drive a geometrical current density of 10 mA cm−2 significantly decreases from – 400 mV vs. the reversible hydrogen electrode (RHE) to −290 mV vs. RHE. For the EOR and MOR, electrochemically activated AuPd realized 3.4- and 2.9- fold increase in mass current density (mA mgPd−1) with respect to the pristine AuPd electrocatalyst, respectively. In situ electrochemical activation as a new pre-treatment method is extremely effective for enhanced electrocatalytic performances for different applications. 相似文献
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Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women
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Narges Roomandeh AboTaleb SaremiJavad ArastehFatemeh PakMajid MirmohammadkhaniParviz Kokhaei Ahad Zare 《Iranian journal of immunology : IJI》2018,15(1):59-67
Background: Increased evidences have shown that unexplained recurrent spontaneous abortion (URSA) is associated with inflammatory responses and breakage of immunological autotolerance. Therefore, the balance between Th17 and Treg cells may elucidate the pathophysiology of URSA. Objective: To investigate the serum concentration of regulatory and inflammatory cytokines associated with Treg and Th17 in both normal and URSA females. Methods: Forty-six women with URSA and 28 non-pregnant control women with at least one successful pregnancy were included. Serum was obtained from both groups and stored at -70°C. The serum concentrations of IL-17, IL-21, IL-22, IL-10, and TGF-β were quantitatively determined by ELISA. Results: The levels of IL-17, IL-21, and IL-22 in sera were significantly higher (P<0.001, P=0.01 and P<0.001, respectively) and TGF-β serum concentration was significantly lower (P=0.02) in URSA women compared with normal controls. Conclusion: Our results suggest that enhancement in Th17-associated cytokine levels and reduction in TGF-β may be one of the factors involved in URSA. 相似文献
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Michael Kongnyuy Courtney J. Berg Kaitlin E. Kosinski David J. Habibian Jeffrey T. Schiff Anthony T. Corcoran 《International journal of hyperthermia》2017,33(7):810-813
Introduction: Salvage treatment options for recurrent unilateral prostate cancer (PCa) after primary radiation are limited and associated with severe complications and poor quality of life measures. Salvage focal cryotherapy (SFC) has shown success in biochemical recurrence (BCR) free survival. We aim to determine if SFC can delay use of androgen deprivation therapy (ADT) in recurrent PCa with low morbidity.Methods: A retrospective review of patients who underwent SFC at our institution from 2007 to 2015 was performed. Patients with?<2 follow-up prostate-specific antigen (PSA) values, metastatic disease, and a history of radical prostatectomy were excluded. Age at treatment, prior treatment history, PSA nadir, complications, BCR status (nadir?+2?ng/ml), and follow-up data were obtained/analysed. ADT was commenced if patient experienced BCR and had a PSA doubling time?<6?months or positive confirmatory biopsy or positive imaging. Cox regression and survival analysis were used to assess confounding and time to BCR respectively.Results: A total of 65 patients were included and followed for a median of 26.6 (8.0–99.0) months. Thirty-one (47.7%) patients did not experience BCR. An even higher number of patients (52/65, 80.0%) are yet to receive ADT. Of those who experienced BCR [median time to BCR, 17.1 [interquartile range (IQR):11.4–23.3] months], 22/34 (64.7%) are currently carefully monitored without ADT. Survival analysis showed a biochemical recurrence-free survival of 48.1 at 1- and 3-year follow up. No patient died/experienced major complications.Conclusions: SFC may be used to delay the use of ADT. Further assessment of our findings with high-powered studies and longer follow-up is required. 相似文献
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Bazazzadegan N Nikzat N Fattahi Z Nishimura C Meyer N Sahraian S Jamali P Babanejad M Kashef A Yazdan H Sabbagh Kermani F Taghdiri M Azadeh B Mojahedi F Khoshaeen A Habibi H Reyhanifar F Nouri N Smith RJ Kahrizi K Najmabadi H 《International journal of pediatric otorhinolaryngology》2012,76(8):1164-1174
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Narges Khosravanian Mazdak Razi Farah Farokhi Hajar Khosravanian 《Journal of assisted reproduction and genetics》2014,31(3):341-354