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81.
Tuberous sclerosis: characteristics at CT and MR imaging 总被引:7,自引:0,他引:7
Computed tomography (CT) and magnetic resonance (MR) imaging findings were reviewed in 26 patients with tuberous sclerosis. All patients underwent CT; 16 patients underwent both. The CT features included subependymal nodules in 25 of 26 patients (96%) and calcifications in 23 of 26 (88%). Parenchymal hamartomas (cortical tubers) were seen in 23 of 26 patients (88%). These lesions had less attenuation than surrounding brain in 16 of 26 patients (62%) and were calcified in 14 of 26 patients (54%). Contrast enhancement of a lesion, indicating a subependymal giant cell astrocytoma, occurred in three of 26 patients (12%). The MR imaging characteristics included subependymal nodules (periventricular nodules) of intermediate signal intensity in ten of the 16 patients (63%). Parenchymal hamartomas, demonstrated in 15 of the 16 patients (94%), usually exhibited long T1 and T2 relaxation characteristics. The pattern was noted to be reversed in the two newborn patients (13%). One parent demonstrated a forme fruste at CT but had a normal MR image. 相似文献
82.
Responsiveness of human male volunteers to immunization with ovine follicle stimulating hormone vaccine: results of a pilot study 总被引:4,自引:0,他引:4
Moudgal NR; Murthy GS; Prasanna Kumar KM; Martin F; Suresh R; Medhamurthy R; Patil S; Sehgal S; Saxena BN 《Human reproduction (Oxford, England)》1997,12(3):457-463
A study of 140 days duration was performed to examine if human male
volunteers (n = 5) respond to ovine follicle stimulating hormone (oFSH)
immunization (administered adsorbed on Alugel on days 1, 20, 40 and 70) by
producing antibodies capable of both binding and neutralizing bioactivity
of human FSH. The kinetics of antibody production for both the immunogen
(oFSH) and the cross-reactive antigen (hFSH) were essentially similar. The
volunteers responded only to the first two immunizations. The boosters
given on days 40 and 70 were ineffective, probably because of the presence
of substantial amounts of circulating antibody to oFSH. Of the antibodies
generated to oFSH, 25-45% bound hFSH with a mean binding affinity of 0.65 x
10(9) +/- 0.53 M(-1). The binding capacities at the time of high (30-80
days of immunization) and low (>110 days) titres were 346 +/- 185 and
10.5 +/- 5.8 ng hFSH/ml respectively. During the period of high titre, free
serum FSH (value in normal males 1-5 ng/ml) was not monitorable. A 50
microl aliquot of the antiserum obtained from different volunteers between
days 30 and 80 and on day 140 blocked binding of (125)I-labelled hFSH to
its receptor by 82 +/- 9.7 and 53 +/- 12.2% respectively. The antibody
produced was specific for FSH, and no significant change in the values of
related glycoprotein hormones (luteinizing hormone/testosterone and thyroid
stimulating hormone/thyroxine) were recorded. Seminal plasma transferrin, a
marker of Sertoli cell as well as of seminiferous tubular function, showed
marked reduction (30-90%) following immunization with oFSH. Considering
that endogenous FSH remained neutralized for approximately one sperm cycle
only (65 days), the reduction in sperm counts (30-74%) exhibited by some
volunteers is encouraging. Immunization with oFSH did not result in any
significant changes in haematology, serum biochemistry or hormonal
profiles. There was no production of antibodies capable of interacting with
non- specific tissues. It is concluded that it should be possible to obtain
a sustained long-term blockade of endogenous FSH action in men by using
oFSH as an immunogen. This is a prerequisite for obtaining significant
reduction in the quality and quantity of spermatozoa produced, thus leading
to infertility.
相似文献
83.
The firing behavior of 51 non-eye movement related central vestibular neurons that were sensitive to passive head rotation in the plane of the horizontal semicircular canal was studied in three squirrel monkeys whose heads were free to move in the horizontal plane. Unit sensitivity to active head movements during spontaneous gaze saccades was compared with sensitivity to passive head rotation. Most units (29/35 tested) were activated at monosynaptic latencies following electrical stimulation of the ipsilateral vestibular nerve. Nine were vestibulo-spinal units that were antidromically activated following electrical stimulation of the ventromedial funiculi of the spinal cord at C1. All of the units were less sensitive to active head movements than to passive whole body rotation. In the majority of cells (37/51, 73%), including all nine identified vestibulo-spinal units, the vestibular signals related to active head movements were canceled. The remaining units (n = 14, 27%) were sensitive to active head movements, but their responses were attenuated by 20-75%. Most units were nearly as sensitive to passive head-on-trunk rotation as they were to whole body rotation; this suggests that vestibular signals related to active head movements were cancelled primarily by subtraction of a head movement efference copy signal. The sensitivity of most units to passive whole body rotation was unchanged during gaze saccades. A fundamental feature of sensory processing is the ability to distinguish between self-generated and externally induced sensory events. Our observations suggest that the distinction is made at an early stage of processing in the vestibular system. 相似文献
84.
McGlinchey PG Spence MS Patterson CC Allen AR Murphy G Belton C McKeown PP 《Tissue antigens》2004,64(2):199-203
Using two recently described family-based tests of association, the possible role of the functional -2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population. One thousand and twelve individuals from 386 families with at least one member prematurely affected with IHD were genotyped for the MCP-1 -2518G/A polymorphism. Using the combined transmission disequilibrium test and the pedigree disequilibrium test, no association between the MCP-1 -2518G/A polymorphism and IHD was found. Our data demonstrate that, in an Irish population, the MCP-1 -2518G/A polymorphism is not strongly associated with IHD. 相似文献
85.
Coronary heart disease (CHD) remains a leading cause of death across the world. A region on chromosome 9p21.3 has been recently reported to be associated with CHD. We evaluated 3 SNPs and 3 common haplotypes in the 9p21.3 region in 1494 individuals from 580 Irish families, where at least 1 member had early-onset (males 相似文献
86.
Weihua Meng Anne Hughes Chris C Patterson Christine Belton Muhammad S Kamaruddin Paul G Horan Frank Kee Pascal P McKeown 《BMC medical genetics》2007,8(1):62
Background
The complement factor H (CFH) gene has been recently confirmed to play an essential role in the development of age-related macular degeneration (AMD). There are conflicting reports of its role in coronary heart disease. This study was designed to investigate if, using a family-based approach, there was an association between genetic variants of the CFH gene and risk of early-onset coronary heart disease. 相似文献87.
Background, purpose and methods: This observational study assessed the effect of continuous intraventricular infusion of pentosan polysulphate (PPS) in seven patients at different clinical centres in the UK.
Results: Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11–110 μ g/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly.
Conclusion: Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored. 相似文献
Results: Complications of intraventricular catheterization were frequent. PPS was well-tolerated over a wide dose range (11–110 μ g/kg/day) during the 6-month study. Four patients were assessed for the entire study period: one remained stable, two showed minimal deterioration and one progressed significantly.
Conclusion: Mean survival of all patients was longer than reported values for natural history of specific prion disorders. Possible reasons for these findings are explored. 相似文献
88.
A large observational study of patients with primary immune thrombocytopenia receiving romiplostim in European clinical practice 下载免费PDF全文
Michael Steurer Philippe Quittet Helen A. Papadaki Dominik Selleslag Jean‐François Viallard Georgia Kaiafa Ann Janssens Tomas Kozak Hans Wadenvik Marieke Schoonen Laura Belton Georg Kreuzbauer 《European journal of haematology》2017,98(2):112-120
Myelodysplastic Syndromes are oligo‐clonal stem cell disorders that are associated with cytopenias in the peripheral blood. Major causes for morbidity and mortality in myelodysplastic syndromes (MDS) patients are infections mostly due to bacteria or fungi. Beside leucopenia per se in affected patients, function of white blood cells particularly that of neutrophils seems to be impaired. Here we summarize the available data on infections in MDS patients in general and particularly those treated with 5‐azacitidine. 相似文献
89.
One thousand and thirty-one singleton children of teenage mothers were compared with 10 950 singleton children of older mothers in a national longitudinal cohort study. Children born to teenage mothers and living with them during the first 5 years were more liable to hospital admissions, especially after accidents and for gastroenteritis, than were children born to and living with older mothers. Frequent accidents, poisoning, burns, and superficial injuries or lacerations were more often reported by teenage mothers. The association of teenage mothering with greater likelihood that children would have accidents or be admitted to hospital remained highly significant even after controlling for social and biological confounding influences. Although in part a marker for adverse socioeconomic circumstances, low maternal age appears to be a health hazard for children. 相似文献
90.
IG Lawrence MRCP RJ Dalby MB ChB NR Lad MB ChB RJ Shepherd FRCP FRCP 《International journal of clinical practice》1996,50(6):346-348
SUMMARY A 23-year-old man, previously fit and well, presented with an atypical pneumonia, associated with microangiopathic anaemia, thrombocytopenia, rhabdomyolysis and renal impairment. Despite administration of intravenous fluids and antibiotics, his condition rapidly deteriorated, and the possibility of an aggressive connective tissue disorder was raised. Thus he was treated with high-dose oral steroids and plasma exchange until autoantibodies were shown to be negative. At this stage it transpired that the patient had swallowed water from a stream three weeks earlier, and leptospira antibody titres were subsequently found to be elevated. Antibiotics were continued, and after a protracted course he made a full recovery. Leptospirosis should be remembered as a rare cause of atypical pneumonia, particularly if there is associated hepatic or renal impairment. 相似文献