Toward Understanding Suicide Among Youths: Results From the White Mountain Apache Tribally Mandated Suicide Surveillance System, 2001�C2006

Objectives. We examined suicide and suicide attempt rates, patterns, and risk factors among White Mountain Apache youths (aged < 25 years) from 2001 to 2006 as the first phase of a community-based participatory research process to design and evaluate suicide prevention interventions.Methods. Apache paraprofessionals gathered data as part of a tribally mandated suicide surveillance system. We compared findings to other North American populations.Results. Between 2001 and 2006, 61% of Apache suicides occurred among youths younger than 25 years. Annual rates among those aged 15 to 24 years were highest: 128.5 per 100 000, 13 times the US all-races rate and 7 times the American Indian and Alaska Native rate. The annual suicide attempt incidence rate in this age group was 3.5%. The male-to-female ratio was 5:1 for suicide and approximately 1:1 for suicide attempts. Hanging was the most common suicide method, and third most common attempt method. The most frequently cited attempt precipitants were family or intimate partner conflict.Conclusions. An innovative tribal surveillance system identified high suicide and attempt rates and unique patterns and risk factors of suicidal behavior among Apache youths. Findings are guiding targeted suicide prevention programs.Suicide is the third leading cause of death among US youths aged 10 to 24 years,¹ and suicide attempts are a major source of adolescent morbidity in the United States. As behavioral scientists have increasingly recognized youths'' suicide behavior as an important and preventable public health problem, Healthy People 2010 has set specific objectives to reduce suicide and suicide attempt rates among youths. Past evidence supports the premise that youth suicide can be prevented by addressing risk factors and promoting early identification, referral, and treatment of mental and substance use disorders. However, risk factors vary across races, ethnic groups, and regions, necessitating targeted formative research and community-specific prevention approaches.²It is well-documented that American Indians and Alaska Natives have the highest rates of suicide of all US races.³ American Indian and Alaska Native (AIAN) suicides occur predominantly among youths ( < 25 years), in contrast to the US general population, in which deaths from suicide are concentrated among the elderly ( ≥ 65 years).⁴ Further, there is significant variability in suicide rates among youths across tribes and rural versus urban AIAN populations. Among the 1.3 million American Indians and Alaska Natives residing on or near rural reservation lands tracked by the Indian Health Service, the average rate of suicide per 100 000 is 20.2, with a range of 7.7 (Nashville area) to 45.9 (Alaska area).⁵ In comparison, for all 4.1 million American Indians and Alaska Natives identified by the US Census, the suicide rate is 11.7.⁶ Because urban AIAN residents compose approximately 60% of the US Census AIAN population,⁷ the lower overall census suicide rate indicates that rural reservation suicide rates are higher than urban AIAN suicide rates.To date, little reservation-specific information on suicide behavior or related risk factors exists to explain differences in rates across AIAN communities and in comparison with other US populations. Developing the means to collect and analyze local tribal data is key to discerning unique risk factors that are driving local and national disparities in suicide among AIAN youths, and to the public health mission of reducing suicide among youths across the United States and the world.There are approximately 15 500 White Mountain Apache (Apache) tribal members who reside on the 1.6 million acre Fort Apache Reservation in east-central Arizona. More than half (54%) of the tribal members are younger than 25 years, compared with approximately 35% of the US all-races population.⁸ In 2001, a cluster of suicides among youths on the Apache reservation led the Tribal Council to enact a resolution to mandate tribal members and community providers to report all suicidal behavior (ideation, attempts, and deaths) to a central data registry. The resulting surveillance system is the first of its kind, gathering data from both community-based and clinical settings.In 2004, as part of the Johns Hopkins Center for American Indian Health, we partnered with the Apaches to conduct a community-based participatory research (CBPR) project that included formalizing the mandated reporting process, transferring the registry system to an electronic format, analyzing quarterly trends, and engaging community leaders in interpreting surveillance data to inform prevention strategies. Because of the contentious history of research in tribal communities, CBPR methodologies are essential to ensuring a culturally sensitive interpretation of findings and culturally relevant interventions.⁹ A CBPR approach is particularly important in the complex area of mental health because explanatory models for cause and treatment of mental illness can vary widely across tribal and nontribal cultures.¹⁰We describe the Apache suicide behavior surveillance system, report patterns of Apache youths'' suicide and suicide attempts between 2001 and 2006, and compare those rates with those of other tribal and North American populations. We discuss the relevance of the paraprofessional-administered surveillance system and its findings to public health prevention of suicide behavior among youths.     

Compensation for fear and worry‐induced psychiatric illness: The Australian position

New species of claims for psychiatric injury will cause courts to reassess the principles governing the way the common law has compensated those compromised by careless exposure to trauma. Pleas are emerging in an increasing variety of scenarios far removed from those which gave rise to the earliest suits for damages for nervous conditions. Recent litigation highlights the inadequacies of the traditional limitations on liability for the negligent infliction of psychiatric disorder, their conflict with contemporary medical and psychological opinion, and the impossibility of analysing many modem allegations by reference to them. The shortcomings of the orthodox approach are no better exposed than by the claims of those who suffer psychiatric damage through the fear or worry of future consequences following their actual or perceived exposure to disease‐causing agents.     

Comparison of the morphological transforming activities of dibenzo[a,l]pyrene and benzo[a]pyrene in C3H10T1/2CL8 cells and characterization of the dibenzo[a,l]pyrene-DNA adducts

C3H10T1/2CL8 (C3H10T1/2) mouse embryo fibroblasts were used to study the in vitro carcinogenic activities of dibenzo[a,l]pyrene (DB[a,l]P) and benzo[a]pyrene (B[a]P). The morphological transforming activities of these rodent carcinogens were compared using replicate concentration- response studies. In concentration ranges where both polycyclic aromatic hydrocarbons (PAHs) were active, DB[a,l]P proved to be four to 12 times as potent as B[a]P based on concentration. At lower concentrations DB[a,l]P was active at 0.10 and 0.20 microM, concentrations where B[a]P was inactive. This makes DB[a,l]P the most potent non-methylated PAH evaluated to date in C3H10T1/2 cells. DNA adducts of DB[a,l]P in C3H10T1/2 cells were analyzed by both TLC and TLC/HPLC 32P-postlabeling methods using mononucleotide 3'-phosphate adduct standards derived from the reactions of anti-DB[a,l]P-11,12-diol- 13,14-epoxide (anti-DB[a,l]PDE) and syn-DB[a,l]P-11,12-diol-13,14- epoxide (syn-DB[a,l]PDE) with deoxyadenosine 3'-monophosphate and deoxyguanosine 3'-monophosphate. All of the DNA adducts observed in C3H10T1/2 cells treated with DB[a,l]P were identified as being derived from the metabolism of DB[a,l]P to its fjord region diol epoxides through DB[a,l]P-11,12-diol. The predominant adduct was identified as an anti-DB[a,l]PDE-deoxyadenosine adduct. Other major adducts were anti- DB[a,l]PDE-deoxyguanosine and syn-DB[a,l]PDE-deoxyadenosine adducts with minor amounts of syn-DB[a,l]PDE-deoxyguanosine adducts. These DNA adduct data are consistent with similar findings of DB[a,l]PDE- deoxyadenosine adducts in mouse skin studies and human mammary cells in culture.      

An experimental in vivo study of the canine internal mammary artery and its response to vasoactive drugs

The internal mammary artery is clearly the preferred conduit for most patients undergoing coronary artery bypass grafting. However, the hemodynamic responses of this graft to vasoactive agents immediately after bypass have not been documented. We have therefore studied blood flow in the canine internal mammary artery after anastomosis to the left anterior descending artery, and its response to epinephrine, metaraminol, isoproterenol, and calcium chloride. Blood flow in the internal mammary artery clearly paralleled changes in systolic blood pressure with perfusion pressure being of prime importance in maintaining flow in the internal mammary artery. No deleterious effect of systemic vasoconstricting agents was demonstrated. We suggest that the administration of these drugs is safe in patients with internal mammary artery grafts.     

Influence of preoperative lipid-lowering therapy on postoperative outcome in patients undergoing coronary artery bypass grafting

Statin therapy has recently been shown to decrease adverse perioperative events in patients undergoing vascular surgery. The potential beneficial effect of lipid-lowering therapy in patients undergoing coronary artery bypass grafting (CABG) is not well known. This was an observational analysis of 4,739 patients who underwent first-time isolated CABG at a single institution from 1995 to 2001. Patients were categorized into 2 groups based on treatment with a lipid-lowering agent within 30 days before surgery. Univariate and multivariate analyses were used to determine the association between lipid-lowering therapy and survival to hospital discharge. Patients in the lipid-lowering group (n = 2,334) tended to be younger (mean age 66 +/- 10 vs 68 +/- 10 years), were more likely to be diabetic (31% vs 28%), and on beta blockers (77% vs 70%) than patients in the nonlipid-lowering group (n = 2,405). In-hospital mortality was significantly lower in the lipid-lowering group than in the nonlipid-lowering therapy group (1.4% vs 2.2%, odds ratio 0.62, 95% confidence interval 0.40 to 0.96, p = 0.03). A multivariable model demonstrated a loss of statistical significance for the effect of lipid-lowering therapy on in-hospital mortality (adjusted odds ratio 0.83, 95% confidence interval 0.5 to 1.37, p = 0.46). In conclusion, preoperative use of lipid-lowering therapy in patients undergoing CABG appears safe and is associated with improved survival to hospital discharge compared with patients not receiving lipid-lowering therapy. However, patient risk factors and other cardioprotective medication use associated with the use of preoperative lipid-lowering therapy appear to explain the association with improved survival.     

Intraoperative hyperglycemia and perioperative outcomes in cardiac surgery patients

OBJECTIVE: To estimate the magnitude of association between intraoperative hyperglycemia and perioperative outcomes in patients who underwent cardiac surgery. PATIENTS AND METHODS: We conducted a retrospective observational study of consecutive adult patients who underwent cardiac surgery between June 10, 2002, and August 30, 2002, at the Mayo Clinic, a tertiary care center in Rochester, Minn. The primary independent variable was the mean intraoperative glucose concentration. The primary end point was a composite of death and infectious (sternal wound, urinary tract, sepsis), neurologic (stroke, coma, delirium), renal (acute renal failure), cardiac (new-onset atrial fibrillation, heart block, cardiac arrest), and pulmonary (prolonged pulmonary ventilation, pneumonia) complications developing within 30 days after cardiac surgery. RESULTS: Among 409 patients who underwent cardiac surgery, those experiencing a primary end point were more likely to be male and older, have diabetes mellitus, undergo coronary artery bypass grafting, and receive insulin during surgery (P< or =.05 for all comparisons). Atrial fibrillation (n=105), prolonged pulmonary ventilation (n=53), delirium (n=22), and urinary tract infection (n=16) were the most common complications. The initial, mean, and maximal intraoperative glucose concentrations were significantly higher in patients experiencing the primary end point (P<.01 for all comparisons). In multivariable analyses, mean and maximal glucose levels remained significantly associated with outcomes after adjusting for potentially confounding variables, including postoperative glucose concentration. Logistic regression analyses indicated that a 20-mg/dL increase in the mean intraoperative glucose level was associated with an increase of more than 30% in outcomes (adjusted odds ratio, 1.34; 95% confidence Interval, 1.10-1.62). CONCLUSION: Intraoperative hyperglycemia is an independent risk factor for complications, including death, after cardiac surgery.