全文获取类型
收费全文 | 13801篇 |
免费 | 592篇 |
国内免费 | 52篇 |
专业分类
耳鼻咽喉 | 223篇 |
儿科学 | 220篇 |
妇产科学 | 178篇 |
基础医学 | 1807篇 |
口腔科学 | 312篇 |
临床医学 | 820篇 |
内科学 | 3811篇 |
皮肤病学 | 289篇 |
神经病学 | 804篇 |
特种医学 | 693篇 |
外科学 | 2206篇 |
综合类 | 56篇 |
预防医学 | 403篇 |
眼科学 | 146篇 |
药学 | 989篇 |
中国医学 | 60篇 |
肿瘤学 | 1428篇 |
出版年
2023年 | 43篇 |
2022年 | 104篇 |
2021年 | 202篇 |
2020年 | 131篇 |
2019年 | 190篇 |
2018年 | 208篇 |
2017年 | 186篇 |
2016年 | 234篇 |
2015年 | 217篇 |
2014年 | 330篇 |
2013年 | 444篇 |
2012年 | 729篇 |
2011年 | 790篇 |
2010年 | 428篇 |
2009年 | 401篇 |
2008年 | 758篇 |
2007年 | 808篇 |
2006年 | 887篇 |
2005年 | 878篇 |
2004年 | 783篇 |
2003年 | 757篇 |
2002年 | 708篇 |
2001年 | 331篇 |
2000年 | 343篇 |
1999年 | 345篇 |
1998年 | 231篇 |
1997年 | 149篇 |
1996年 | 146篇 |
1995年 | 114篇 |
1994年 | 107篇 |
1993年 | 104篇 |
1992年 | 224篇 |
1991年 | 200篇 |
1990年 | 184篇 |
1989年 | 184篇 |
1988年 | 160篇 |
1987年 | 159篇 |
1986年 | 144篇 |
1985年 | 140篇 |
1984年 | 105篇 |
1983年 | 74篇 |
1982年 | 42篇 |
1981年 | 56篇 |
1980年 | 57篇 |
1979年 | 66篇 |
1978年 | 40篇 |
1977年 | 53篇 |
1975年 | 43篇 |
1971年 | 45篇 |
1968年 | 43篇 |
排序方式: 共有10000条查询结果,搜索用时 375 毫秒
41.
Peritumoral brain edema associated with meningioma--histological study of the tumor margin and surrounding brain. 总被引:2,自引:0,他引:2
Thirty-nine cases of intracranial meningiomas were analyzed to identify factors causing brain edema. Edema was significantly correlated with tumor size and the destruction of the leptomeninges and cortex. Meningotheliomatous meningioma tended to have more peritumoral edema. There was no correlation between the presence of edema and location of the tumor or histological features including lymphocytic infiltration and the presence of glial fibrillary acidic protein-positive cells in the tumor tissue. Larger tumors destroy the leptomeninges and cerebral cortex, allowing direct transmission of humoral edema-promoting factor or edema fluid into the white matter, resulting in vasogenic edema. 相似文献
42.
43.
E Ohshima H Takami H Sato S Mohri H Obase I Miki A Ishii S Shirakura A Karasawa K Kubo 《Journal of medicinal chemistry》1992,35(18):3402-3413
A series of 11-[2-(1-benzimidazolyl)ethylidene]-6,11-dihydrodibenz[b,e]oxep in-2- carboxylic acid derivatives and related compounds were synthesized and found to be potent TXA2/PGH2 receptor antagonists. Each compound synthesized was tested for its ability to displace [3H]U-46619 binding from guinea pig platelet TXA2/PGH2 receptors. Structure-activity relationship studies revealed that the following key elements were required for enhanced activities: (1) an (E)-2-(1-benzimidazolyl)ethylidene side chain in the 11-position of the dibenzoxepin ring system and (2) a carboxyl group in the 2-position of the dibenzoxepin ring system. The studies also indicated that the TXA2/PGH2 receptor binding affinities of this series of compounds in guinea pig platelet were poorly correlated with those in human platelet. Introduction of substituent(s) to the benzimidazole moiety was effective and sodium (E)-11-[2-(5,6-dimethyl-1-benzimidazolyl)ethylidene]- 6,11-dihydrodibenz[b,e]oxepin-2-carboxylate monohydrate (57) recorded the highest affinity for human platelet TXA2/PGH2 receptor with a K(i) value of 1.2 +/- 0.14 nM. It demonstrated potent inhibitory effects on U-46619-induced guinea pig platelet aggregation (in vitro and ex vivo) and human platelet aggregation (in vitro). Compound 57, now designated as KW-3635, is a novel, orally active, and specific TXA2/PGH2 receptor antagonist with neither TXA2/PGH2 receptor agonistic nor TXA2 synthase inhibitory effects. It is now under clinical evaluation. 相似文献
44.
45.
K Uchida M Tobe T Ozaki T Hamada N Kubo S Satou 《[Zasshi] [Journal]. Nihon Kyōbu Geka Gakkai》1992,40(11):2087-2090
A 46-year-old man was referred to our hospital because of prosthetic valve regurgitation. Eight years previously he had undergone aortic valve replacement because of aortic regurgitation due to infective endocarditis. At reoperation, we found prosthetic valve endocarditis and discrete subaortic stenosis. The obstructing fibrous tissue was resected and the aortic valve was replaced. Because discrete subaortic stenosis is usually located just below the aortic valve, the aortic valve cusps are liable to become thickened by the jet through the discrete stenosis and thus are vulnerable to infective endocarditis. It is pointed out that care must be taken not to overlook discrete subaortic stenosis in the presence of other associated cardiac disorders. 相似文献
46.
Hiromitsu Matsuzaki Hiroyuki Hata Norio Asou Minoru Yoshida Fumihiko Matsuno Motohiro Takeya Kazunari Yamaguchi Isao Sanada Kiyoshi Takatsuki 《Cancer science》1992,83(5):450-457
A stable cell line, KHM-3S, was established from a patient with small cell lung cancer (SCLC), who had a high serum level of soluble interleukin 2 receptors (sIL2-R) and was seropositive for human T cell leukemia virus (HTLV)-l. KHM-3S cells were positive for IL2-R (Tac) and NKH-1, but negative for other lymphocytic markers such as OKT 11, OKT 4, OKT 8, T cell receptor (WT 31), B 1, and B 4. Moreover, the KHM-3S cells were negative for leukocyte common antigen and strongly positive for neuron-specific enolase (NSE). Secretion of sIL2-R and NSE by the KHM-3S line was detected by an enzyme-linked immunosorbent assay. Rearrangement of the T cell receptor gene and monoclonal HTLV-1 integration were found by Southern blot analysis of KHM-3S DNA. However, Northern blot analysis showed no T cell receptor mRNA. KHM-3S may be useful for studies on the role of HTLV-1 in carcinogenesis and IL2-R expression in SCLC. 相似文献
47.
Satoshi Yoneda Yozo Kobayashi Takehiro Nunoi Kosuke Takeda Atsushi Matsumori Minoru Andoh Hirohisa Tsujinoue Kimio Nishimura Hiroshi Fukui 《Nihon Shokakibyo Gakkai zasshi》2006,103(11):1270-1273
A 23-year-old woman had lower abdominal pain, diarrhea and bloody stool was admitted and given a diagnosis of influenza B. Her home doctor had started treatment by neuraminidase inhibitor (oseltamivir) the previous day. Colonoscopic examination revealed an area of hemorrhage and erosion in the left transverse colon. After halting oseltamivir treatment these symptoms disappeared and her colonoscopic findings improved. A drug-induced lymphocyte stimulation test was positive for oseltamivir. This case is the first reported case of acute hemorrhagic colitis induced by oseltamivir. 相似文献
48.
Shinji Homma Kenji Satoh Hitoshi Matsuo Minoru Yagi Jun Hasegawa Tomoyuki Maruta Naozumi Watanabe Tsuneo Iiai Katsuyoshi Hatakeyama 《Journal of Smooth Muscle Research》2004,40(6):271-280
Electrogastrograms (EGGs) were recorded in patients both before and after receiving proximal gastrectomy plus jejunal interposition (PGJI) or just after receiving total gastrectomy plus jejunal interposition (TGJI). Intraluminal pressure was also recorded in some postoperative patients. The EGG 3 cpm component (2.5-4.9 cpm) remained after PGJI, but subsequently decreased with a significant reduction in the preoperative to postoperative ratio of the 3 cpm components (P<0.05). The mean frequency of the 3 cpm components increased significantly after PGJI (P<0.05) and its instability factor increased. The EGG 10 cpm components became relatively dominant compared to other frequency components in 2 out of 8 of patients having PGJI but the mean amplitude of 10 cpm decreased. In TGJI patients, only the 10 cpm component was conspicuous in EGG as in the case of total gastrectomy and Roux en Y anastomosis procedures. The spectral frequencies of intraluminal pressure in the interposed jejunum were similar to the EGG of 10 cpm components both in the case of PGJI and TGJI patients. In conclusion, surface EGG could record the electrical activities of the interposed jejunum more easily in patients having had TGJI than in PGJI. 相似文献
49.
Denopamine (15 mg/day) was administered to 20 patients with residual left ventricular dysfunction after successful percutaneous transluminal coronary angioplasty (75% or more diameter stenosis). Echocardiography was performed before and 6 months after denopamine administration to analyze the left ventricular function. There were significant decreases in both end-diastolic and end-systolic dimensions from 58 +/- 8.3 to 54 +/- 8.4 mm (p = 0.001), and from 44 +/- 10.1 to 40 +/- 10.3 mm (p = 0.005)), respectively, while % fractional shortening remained nearly constant (from 25 +/- 8.3 to 27 +/- 9.6%). Thus, denopamine improved the left ventricular function by decreasing left ventricular size while maintaining wall contractility. 相似文献
50.