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991.
Roger Badia Antoni Iborra José Ramón Palacio Marta Antich Paz Martínez 《American journal of reproductive immunology (New York, N.Y. : 1989)》2008,60(4):354-360
Problem Human seminal plasma (SP) has an important immunosuppressive function that enables sperm survival in the female reproductive tract. The aim of this study was to evaluate how oxidized proteins, by oxidative stress, may influence seminal plasma immunosuppressive properties in male infertility. Method of study Human SP immunosuppressive ability was evaluated by a lymphocyte proliferation assay. We used phytohemagglutinin mitogen to induce lymphocyte proliferation in the presence of human SP from infertile and fertile men, and under in vitro oxidizing conditions. Human SP‐oxidized proteins (MDA‐protein) were determined by the thiobarbituric acid test. Results Significant high levels of oxidized proteins were found in SP from asthenozoospermic patients. There was a significant difference (P < 0.05) between lymphocyte proliferation in the presence of SP from normozoospermic and asthenozoospermic group compared to the fertile donor group. Oxidized human SP in vitro allows for higher lymphocyte proliferation than non‐oxidized SP. Conclusion Human SP proteins have an inhibitory ability on lymphocyte proliferation, but under oxidative stress conditions, these proteins lose their immunosuppressive function. 相似文献
992.
993.
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995.
Ventral approach to the rat middle ear for otologic research. 总被引:1,自引:0,他引:1
M Pinilla R Ramírez-Camacho E Jorge A Trinidad J Vergara 《Otolaryngology--head and neck surgery》2001,124(5):515-517
996.
Gabriel Mercadal Orfila Berta Gracia García Elisabet Leiva Badosa María Perayre Badía Concepción Reynaldo Martínez Ramón Jodar Masanés 《Pharmacy World & Science》2009,31(2):224-229
Objective There is currently a controversy regarding interactions between levofloxacin and warfarin. The aim of this study was to determine
the clinical relevance of this interaction in our setting. Setting A university hospital in Barcelona, Spain. Methods We carried out a retrospective evaluation of all patients hospitalized in our hospital during the period 2000–2005, selecting
all those concomitantly treated with levofloxacin and warfarin for the study. The following data were compiled: demographic
information, concomitant medication, comorbid conditions, and relevant analytical parameters, particularly the international
normalized ratio (INR), including values taken before, during, and after concomitant administration of the two study drugs.
Patients for whom INR values during concomitant administration were not available were excluded. Differences in INR before
and during the potential interaction, and before and after the interaction were analyzed with the Wilcoxon t test using SPSS (V12.0). In addition, patients were stratified according to presence or not of toxic habits (smoking/alcohol
consumption) to investigate the possible impact of these factors on the interaction under study. Results Among the 30 patients identified, 9 were excluded because INR data during concomitant administration of warfarin and levofloxacin
were not available. Statistical analysis demonstrated significant increase in INR (P = 0.001) following addition of levofloxacin to warfarin therapy. Conclusions. The results of this study reaffirm the hypothesis that concomitant administration of levofloxacin and warfarin leads to
INR increase; hence close monitoring of INR is advisable when patients are prescribed this combination of drugs.
This paper has not been submitted elsewhere in similar form, and all authors have contributed significantly to the publication.
All authors are aware of the submission and agree with it. 相似文献
997.
998.
Angel Josabad Alonso-Castro Candy Carranza-álvarez Ma Catalina Alfaro-De la Torre Leonardo Chávez-Guerrero Ramón Fernando García-De la Cruz 《Archives of environmental contamination and toxicology》2009,57(4):688-696
We investigated the effect of Cd and Pb on the growth of the aquatic macrophyte Typha latifolia; the removal from the solution and the accumulation of these elements by the plant were also studied. Thus, small plants
of T. latifolia, collected from a noncontaminated site, were exposed for 10 days to Cd and Pb, in a single solution or in mixture solutions,
at two concentrations of the metals (5 and 7.5 mg/L). Our results showed that T. latifolia removed effectively Cd and Pb from solutions and was able to accumulate these metals in the roots and, to a lesser extent,
in the leaves. Our findings suggested a synergistic effect of Cd and Pb with respect to the toxicity to T. latifolia. Additionally, Cd diminished the Pb absorption by T. latifolia. Our results confirmed, using scanning electron microscopy, the internalization of Cd and Pb in T. latifolia. 相似文献
999.
1000.