全文获取类型
收费全文 | 243篇 |
免费 | 9篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 12篇 |
妇产科学 | 1篇 |
基础医学 | 31篇 |
口腔科学 | 7篇 |
临床医学 | 40篇 |
内科学 | 53篇 |
皮肤病学 | 14篇 |
神经病学 | 10篇 |
外科学 | 35篇 |
综合类 | 4篇 |
预防医学 | 3篇 |
眼科学 | 1篇 |
药学 | 11篇 |
肿瘤学 | 30篇 |
出版年
2022年 | 3篇 |
2021年 | 2篇 |
2016年 | 6篇 |
2015年 | 5篇 |
2014年 | 6篇 |
2013年 | 2篇 |
2012年 | 4篇 |
2011年 | 3篇 |
2010年 | 7篇 |
2009年 | 9篇 |
2008年 | 2篇 |
2007年 | 3篇 |
2006年 | 9篇 |
2004年 | 4篇 |
2003年 | 9篇 |
2002年 | 3篇 |
1999年 | 3篇 |
1998年 | 12篇 |
1997年 | 15篇 |
1996年 | 12篇 |
1995年 | 10篇 |
1994年 | 7篇 |
1993年 | 6篇 |
1992年 | 2篇 |
1991年 | 4篇 |
1989年 | 3篇 |
1988年 | 3篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1982年 | 5篇 |
1981年 | 6篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1977年 | 3篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1973年 | 1篇 |
1971年 | 1篇 |
1968年 | 1篇 |
1959年 | 3篇 |
1958年 | 8篇 |
1957年 | 12篇 |
1956年 | 12篇 |
1955年 | 7篇 |
1954年 | 6篇 |
1949年 | 1篇 |
1948年 | 2篇 |
排序方式: 共有253条查询结果,搜索用时 29 毫秒
41.
Narikazu BOKU Atsushi OHTSU Takahiro FUJII Ikuro KOBA Koichi HOSOKAWA Yasushi ODA Kei MURO Keisho CHIN Kazuhiro KANEKO Hisao TAJIRI Shigeaki YOSHIDA Masahiro ONO Taira KINOSHITA Takahiro HASEBE Kiyoshi MUKAI Kaoru ABE 《Digestive endoscopy》1996,8(2):122-126
Abstract: Accurately diagnosing the depth of invasion in small early gastric cancers is essential for determining whether endoscopic resection of a lesion is indicated. It is often difficult, however, to demonstrate such small lesions by conventional endoscopic ultrasonography (EUS) which is considered to be a useful tool for assessing depth of invasion. To facilitate demonstration by EUS, we injected 2-5 ml of saline into the submucosal layer at an appropriate point 1 -2 cm from the lesion. With the collection of saline serving as a guide, the lesion was demonstrable on the same EUS image (“para-lesional” injection method). Using this method, we were able to evaluate all 12 of the small early gastric cancers we examined. Five of these lesions were endoscopically resected uneventfully after EUS examination. The accuracy of the diagnosis of vertical invasion with this method was 83% (10/12). Histologically, fibrotic changes were observed beside the lesion, but no EUS-related effects were recognized beneath the lesion. The present results suggest that the “para-lesional” injection method is useful for assessing small early gastric cancers by conventional EUS. 相似文献
42.
M. MASUZAWA T. KAMADA H. ABE Y. SAKOYAMA S. OKUBO 《Scandinavian journal of immunology》1978,8(S8):519-526
Human serum alkaline phosphatase (E.C. 3.1.3.1.) was subclassified into several isoenzymes including carcinoplacental alkaline phosphatase isoenzyme (CPALP) by electrophoretic procedures. Since CPALP has three subtypes, such as Regan, Nagao and Variant type, their properties are somewhat different among them, and have no specific property, no simple method has yet been ascertained to detect CPALP separately.
CPALP was detected as the fastest migrating isoenzyme band to the anode, using the polyacrylamide gel electrophoresis of more than 8.0% gel concentration. Thus, a polyacrylamide gradient gel electrophoresis of 16–8% gel concentration in Tris-borate buffer system was introduced, which resulted in CPALP being found to be the fastest migrating isoenzyme band to the anode and microheterogeneities of each CPALP were also identified: CPALP (Variant) was electrophoresed rather faster to the anode, CPALP (Nagao); intermediate, and CPALP (Regan), as well as placental alkaline phosphatase isoenzyme; rather slower. In addition, each isoenzyme of CPALP and placental alkaline phosphatase further differentiated clearly into a few subbands.
Slow moving new bands appeared by Triton X-100 treatment. 相似文献
CPALP was detected as the fastest migrating isoenzyme band to the anode, using the polyacrylamide gel electrophoresis of more than 8.0% gel concentration. Thus, a polyacrylamide gradient gel electrophoresis of 16–8% gel concentration in Tris-borate buffer system was introduced, which resulted in CPALP being found to be the fastest migrating isoenzyme band to the anode and microheterogeneities of each CPALP were also identified: CPALP (Variant) was electrophoresed rather faster to the anode, CPALP (Nagao); intermediate, and CPALP (Regan), as well as placental alkaline phosphatase isoenzyme; rather slower. In addition, each isoenzyme of CPALP and placental alkaline phosphatase further differentiated clearly into a few subbands.
Slow moving new bands appeared by Triton X-100 treatment. 相似文献
43.
When compared with their older counterparts, younger women are more likely to have
depressive symptoms because they more often experience interrupted work history and a
heavy childrearing burden. The purposes of the present study were 1) to investigate the
possible association of psychosocial work environment with psychological distress and 2)
to examine the way by which communication and support in the workplace affect to
psychological distress among young women. We studied 198 women aged 20 to 39 yr in a
cross-sectional study. The Kessler Scale-10 (K10 Scale) was used to examine psychological
distress. In employees who experienced interpersonal conflict, those who had little or no
conversations with their supervisor and/or co-workers had a significantly increased risk
of psychological distress (OR, 4.2), and those who received little or no support from
their supervisor and/or co-workers had a significantly increased risk of psychological
distress (OR, 3.8) compared to those who had more frequent communication and received more
support. Harmonious communication in the workplace can help prevent psychological distress
among employees, which in turn may enable them to be satisfied with their work. 相似文献
44.
Ultrastructural features of goat oviductal secretory cells at follicular and luteal phases of the oestrous cycle 总被引:1,自引:0,他引:1
HIROYUKI ABE MASAKAZU ONODERA SHICHIRO SUGAWARA TAKESHI SATOH HIROYOSHI HOSHI 《Journal of anatomy》1999,195(4):515-521
The aim of the present study was to investigate the ultrastructure of secretory cells in the various regions of the goat oviduct during the follicular and luteal phases of the oestrous cycle. During the follicular phase in the fimbriae, the secretory cells contained small secretory granules with electron-dense matrices. In the luteal phase, the secretory granules disappeared and cytoplasmic protrusions, extending beyond the luminal border of the ciliated cells and often containing the nucleus, were predominant. During the follicular phase in ampullary secretory cells, numerous secretory granules with moderately electron-dense matrices were present in the supranuclear cytoplasm and exocytosis of secretory granules was observed. The number of secretory granules was dramatically reduced in the ampullary secretory cells at the luteal phase. Conspicuous cytoplasmic protrusions of secretory cells were observed similar to those of the fimbrial epithelium. Isthmic cells were almost free of secretory granules and lysosome-like bodies were found both at the follicular and luteal phases. In conclusion, our ultrastructural observations of goat oviduct revealed marked cyclic changes in the ultrastructural features of secretory cells and the ultrastructural features and the numbers of secretory granules were distinctive for each particular segment. 相似文献
45.
TETUO KUZE NAOYA NAKAMURA YUKO HASHIMOTO MASAFUMI ABE HARUKI WAKASA 《The Journal of pathology》1996,180(3):236-242
The clinicopathological features, the immunophenotype, and the presence of Epstein–Barr virus (EBV)-associated genomes and gene products were examined in 17 cases of CD30+ anaplastic large cell lymphoma (ALCL) of B-cell type. Microscopically, the 17 cases were divided into ten cases of the monomorphic type and seven cases of the pleomorphic type. EBV was detected in 6 of 17 cases (38 per cent) by RNA in situ hybridization (ISH) with EBV-encoded RNA (EBER1). EBER1+ cases consisted of two cases (20 per cent) of the monomorphic type and four cases (57 per cent) of the pleomorphic type. The five EBER1+ cases showed clonality of the EBV genome by Southern blotting, consistent with the presence of EBV in a monoclonal proliferation. The EBV-encoded latent membrane protein 1 (LMP1) was found in all six EBER1+ cases and EBV-encoded nuclear antigen 2 (EBNA2) was present in two cases by immunohistochemistry. No expression of LMP1 or EBNA2 was observed in the EBER1− cases. The EBER1+ cases had a tendency for a more favourable prognosis than the EBER1− cases. It is concluded that EBV has an association with CD30+ ALCL of B-cell type in the Japanese population studied, and especially with the large pleomorphic type. EBV infection may play a pathoaetiological role and may influence clinical behaviour. 相似文献
46.
47.
48.
KENSHI UEMURA M.D. HIDEKAZU KONDO M.D. Ph.D. YUMI ISHII M.D. MAMI KOBUKATA M.D. MIHO HARAGUCHI M.D. TAKAAKI IMAMURA M.D. TOYOKAZU OTSUBO M.D. YUKI IKEBE‐EBATA M.D. ICHITARO ABE M.D. REIKA AYABE M.D. SHOTARO SAITO M.D. Ph.D. KOHEI AOKI M.D. YASUKO NAGANO‐TORIGOE M.D. Ph.D. HIDEFUMI AKIOKA M.D. TETSUJI SHINOHARA M.D. Ph.D. YASUSHI TESHIMA M.D. Ph.D. TAKAYUKI MASAKI M.D. Ph.D. KUNIO YUFU M.D. Ph.D. MIKIKO NAKAGAWA M.D. Ph.D. NAOHIKO TAKAHASHI M.D. Ph.D. 《Journal of cardiovascular electrophysiology》2016,27(8):981-989
49.
Suppression of contact sensitivity by local hyperthermia treatment due to reduced Langerhans cell population in mice 总被引:1,自引:0,他引:1
A. YOSHIOKA Y. MIYACHI S. IMAMURA M. HIRAOKA S. JO M. ABE 《The British journal of dermatology》1989,120(4):493-501
The effects of local hyperthermia treatment on contact sensitivity (CS) and on the number of Langerhans cells (LCs) were studied in mice. CS was significantly suppressed when mice were sensitized in the hyperthermia treated skin I, 2 or 4 days after treatment (43 degrees C for 45 min). This suppressive effect was not observed 7 or 14 days after the treatment. CS was also suppressed when mice were sensitized in non-treated skin I day after the treatment. The density of LCs detected as ATPase-positive cells also decreased significantly 1, 2, 4 and 7 days after the treatment. There appeared to be a positive correlation between the number of LCs and the extent of CS when mice were sensitized at hyperthermia treated skin. It was observed that this suppressive effect on CS was dose- and temperature-dependent. It could be transferred by spleen cells from the hyperthermia treated and DNFB-sensitized donors, and was antigen specific when spleen cells were transferred before sensitization of the recipient mice. This indicated it was, in part, associated with the induction of suppressor cells. These findings suggest that local hyperthermia treatment reduces the number of LCs with subsequent suppression of the induction phase of delayed-type hypersensitivity by the generation of antigen-specific suppressor cells. 相似文献
50.