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71.
72.
Lenny H.E. Winkel Bas Vriens Gerrad D. Jones Leila S. Schneider Elizabeth Pilon-Smits Gary S. Ba?uelos 《Nutrients》2015,7(6):4199-4239
Selenium (Se) is an essential element for humans and animals, which occurs ubiquitously in the environment. It is present in trace amounts in both organic and inorganic forms in marine and freshwater systems, soils, biomass and in the atmosphere. Low Se levels in certain terrestrial environments have resulted in Se deficiency in humans, while elevated Se levels in waters and soils can be toxic and result in the death of aquatic wildlife and other animals. Human dietary Se intake is largely governed by Se concentrations in plants, which are controlled by root uptake of Se as a function of soil Se concentrations, speciation and bioavailability. In addition, plants and microorganisms can biomethylate Se, which can result in a loss of Se to the atmosphere. The mobilization of Se across soil-plant-atmosphere interfaces is thus of crucial importance for human Se status. This review gives an overview of current knowledge on Se cycling with a specific focus on soil-plant-atmosphere interfaces. Sources, speciation and mobility of Se in soils and plants will be discussed as well as Se hyperaccumulation by plants, biofortification and biomethylation. Future research on Se cycling in the environment is essential to minimize the adverse health effects associated with unsafe environmental Se levels. 相似文献
73.
Guerrero P Fuchs FD Moreira LM Martins VM Bertoluci C Fuchs SC Gus M 《Clinical and experimental hypertension (New York, N.Y. : 1993)》2008,30(7):553-564
A large proportion of patients with hypertension need a second drug to reach satisfactory control of blood pressure (BP), but there are few well-designed controlled trials comparing the efficacy of drugs added as a second option. In a double-blind randomized clinical trial, 82 patients with uncontrolled BP, receiving hydrochlorothiazide 25 mg daily, were selected to receive amiloride 2.5-5 mg/day (n = 39) or enalapril 10-20 mg/day (n = 43). Ambulatory blood pressure monitoring (ABPM) was done before and after 12-weeks of treatment. Office BP was measured in the 4(th), 8(th), and 12(th) weeks. The doses of amiloride and enalapril were doubled in the fourth week, and propranolol was added in the 8th week if office BP was above 140/90 mm Hg. There was a greater BP reduction in patients treated with enalapril. The ABPM delta values between the groups were 3.6 +/- 2.2, 3.9 +/- 2.2, and 1.1 +/- 2.7 mmHg for 24-h, daily, and nightly systolic blood pressure, respectively, favoring enalapril. For diastolic blood pressure (DBP), the deltas were 1.7 +/- 2.0, 3.2 +/- 1.5, and 1.2 +/- 1.9 mmHg, respectively (p = 0.039 for daily DBP). Office SBP decreased more and sooner in patients allocated to enalapril (p = 0.003). More patients taking amiloride required propranolol to control BP (p = 0.035). Potassium increased 0.3 mEq/L on the average in both groups. Cough, albeit predominantly mild, was reported more frequently by participants treated with enalapril. We conclude that enalapril is more effective than amiloride to lower BP of patients on hydrochlorothiazide with uncontrolled BP. 相似文献
74.
Teimourian S Rezvani Z Badalzadeh M Kannengiesser C Mansouri D Movahedi M Zomorodian E Parvaneh N Mamishi S Pourpak Z Moin M 《International journal of hematology》2008,87(4):398-404
Chronic granulomatous disease (CGD) is an inherited disorder of pathogen killing by phagocytic leukocytes caused by mutations
in NADPH oxidase subunits. Patients with CGD have life-threatening bacterial and fungal infections. Children’s Medical Center
at Tehran University is the referral center for immunodeficiency in Iran. During 2 years of study, 11 non-consanguineous families
with clinically diagnosed CGD were referred to this center. In functional assays performed on neutrophils from affected children
and their mothers; no activity or strongly decreased oxidase activity was detected in the patients’ cells. In oxidase tests
that scored this activity on a per-cell basis, a mosaic pattern was detected in the neutrophils from all 11 mothers. Western
blot analysis revealed an X91° phenotype in all patients. Mutation screening in the CYBB gene encoding gp91phox by SSCP analysis followed by sequencing showed nine different mutations, including two novel mutations. The present survey
is the first study aimed to analyze the clinical features and the molecular diagnosis of X-CGD in Iranian patients. 相似文献
75.
Camila Alexandrina Figueiredo PhD Maurício Lima Barreto Neuza Maria Alcantara-Neves Laura Cunha Rodrigues Philip John Cooper Alvaro A. Cruz Lain Carlos Pontes-de-Carvalho Denise C. Lemaire Ryan dos Santos Costa Leila D. Amorim Candelaria Vergara Nicholas Rafaels Li Gao Cassandra FosterMonica Campbell BS Rasika A. Mathias Kathleen C. Barnes 《The Journal of allergy and clinical immunology》2013
76.
Maryam Razzaghy-Azar Ali Moghimi Nader Sadigh Mehdi Montazer Pedram Golnari Leila Zahedi-Shoolami 《Annals of human biology》2013,40(5-6):628-633
The aim of this study was to determine the age of appearance of secondary sexual characteristics in Iranian girls living in Tehran. A cross-sectional study was conducted between 2003 and 2004 on 1420 6–17-year-old females in different parts of Tehran. Data were collected on the basis of a multistage probability sampling. Secondary sexual characteristics were evaluated by inspection and palpation, and were recorded according to Tanner staging. The subjects were asked about the occurrence of menarche and the age of its onset. Generalized additive logistic modelling was used for the analysis of data. The median age (percentile 10–percentile 90) of Tanner 2 of breast development (B2) and Tanner 2 of pubic hair growth (P2) among 1136 girls was 9.74 years (8.23–11.94) and 10.49 years (8.86–12.17), respectively. The ages of the 2.5 percentile for B2 and P2 were 7.42 and 7.03 years, respectively, so the onset of puberty at <7 years and 5 months is considered precocious in this population. The median age of menarche in 399 girls was 12.68 years (11.27–15.96). 相似文献
77.
Rogier Thomas Eberl Isabelle Moretto Florian Sixt Thibault Catherine François-Xavier Estève Clémentine Abdallahoui Maroua Behague Lucile Coussement Antoine Mathey Lucas Mahy Sophie Buisson Marielle Salmon-Rousseau Arnaud Duong Michel Chavanet Pascal Bernard Quentin Nicolas Barbara Benguella Leila Bonnotte Bernard Blot Mathieu Piroth Lionel 《European journal of clinical microbiology & infectious diseases》2021,40(9):2023-2028
European Journal of Clinical Microbiology & Infectious Diseases - During an epidemic period, we compared patients hospitalized for initial suspicion of COVID-19 but for whom an alternative... 相似文献
78.
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80.
Eli E. Machtei Georgios Romanos Philip Kang Suncica Travan Stephan Schmidt Evangelos Papathanasiou Nikolaos Tatarakis Moshik Tandlich Leila H. Liberman Jacob Horwitz Seyed Hossein Bassir Srinivas Myneni Harlan J. Shiau Lior Shapira Nikos Donos Athena Papas Joerg Meyle William V. Giannobile Panos N. Papapanou David M. Kim 《Journal of periodontology》2021,92(1):11-20