Synthesis and antinociceptive activity of (5-chloro-2(3<Emphasis Type="Italic">H</Emphasis>)-benzoxazolon-3-yl) propanamide derivatives

In this study, (5-chloro-2(3H)-benzoxazolon-3-yl)propanamide derivatives were synthesized. The chemical structures of the compounds were elucidated by their IR and 1H-NMR spectral data and microanalysis. The compounds were tested for antinociceptive activity by using the tail clip, tail flick, hot plate, and writhing methods. The varying levels of antinociceptive activity of the compounds were compared with those of dipyrone and aspirin. Among these compounds, compound 5e, 5g, and 5h have been found to be significantly more active than the others and the standards in all the tests.     

Evaluation of finishing and polishing techniques on surface roughness of chromium-cobalt castings

The effect of finishing and polishing techniques on surface roughness of a chromium-cobalt alloy was evaluated by means of a stylus profile instrumentation and scanning electron microscopy. Scanning electron micrographs, surface profile tracings, surface roughness recordings, and statistical analysis of data support the finding that the best surface finish is obtained when sandblasting, hard stone, medium abrasive disk, second sandblasting, electropolishing, hard rubber point, hard felt disk with pumice slurry, and felt disk and soft brush with polishing paste are used progressively. The results of this study indicate that the finishing procedure should be carried out in a logical, systematic sequence of steps.     

The Effect of Dexpanthenol on Ototoxicity Induced by Cisplatin

ObjectivesThis study was aimed to investigate the protective effects of dexpanthenol (Dxp) on against cisplatin-induced ototoxicity. MethodsTo examine this effect, distortion product otoacoustic emissions (DPOAEs) measurements and serum levels of oxidative and antioxidant status (including malondialdehyde, superoxide dismutase, catalase, glutathione, glutathione peroxidase, total oxidant status, total antioxidant status, and oxidative stress index) were evaluated. Thirty-two adult female Wistar albino rats were randomly divided into 4 equal groups; control (K), cisplatin (C), cisplatin plus Dxp (CD), and Dxp (D). In all groups DPOAEs measurements, between 996 and 10,078 Hz as DPOAEs and input/output functions, were performed on days 0, 1th, 5th, and 12th. Prior to death, the last DPOAEs measurements and blood samples were taken. ResultsIn the C group, statistically significant differences were detected at all frequencies between 0 and 5 days and 0 and 12 days measurements (P<0.05). Serum level of oxidant and antioxidant status were detected statistically significantly changed in this group versus K group (P<0.05). Contrary to the C group, in the CD group hearing ability was seen largely preserved at many frequencies and serum levels of all biochemical parameters were shifted toward normal values, similar to the K group. No significant differences were detected in the either D or K group’s measurements. ConclusionAccording to these results, Dxp may prevent cisplatin-induced ototoxicity.     

Phakic posterior chamber plate intraocular lenses for high myopia.

PURPOSE: Refractive correction of high myopia with phakic minus power intraocular lenses (IOLs) may give dramatic visual results. Various types of lenses developed for this purpose have not gained widespread use due to complications. Long-term results and complications of phakic posterior chamber lenses are yet unknown. The purpose of this study was to evaluate long-term refractive results and complications of early design phakic posterior chamber lenses. METHODS: Thirty-four high myopic eyes implanted with phakic posterior chamber IOLs designed by Fyodorov were evaluated retrospectively. Follow-up time ranged from 36 to 62 months. Corneal endothelial cell counts were made at the central cornea preoperatively and in the sixth month in 18 eyes and in the twelfth month in 14 eyes. RESULTS: Preoperative refractions were between -7.75 and -21.00 D; refractions at the end of the follow-up period were between -5.75 and +3.00 D. Sixty-three percent of eyes were in the +/-2.00-D range. Endothelial cell loss was 9% at 6 months and 10.22% at 12 month. The difference in endothelial cell counts at 6 and 12 months was not statistically significant. CONCLUSIONS: Early design phakic posterior chamber IOLs implanted in this study were developed by Fyodorov and are not used currently. These IOLs provided a stable and reversible refractive correction without leading to cataract formation. Endothelial loss was limited to surgical trauma. Moderate predictability of refractive correction and frequent decentrations with these lenses were linked to the early design of these IOLs.     

Health literacy and knowledge of antenatal care among pregnant women

Health literacy has a direct impact on pregnancy from the perspectives of both the mother and the baby. This study aimed to determine the level of health literacy and assess the knowledge of antenatal care among pregnant women. From among all pregnant women who presented to the hospital's obstetric polyclinic during the study's timeline, the study group consisted of 460 women who agreed to take part (492 women were invited and a response rate of 93.5% was achieved). A questionnaire prepared based on the literature in line with the study's objectives was completed by the participants under supervision. The Turkish Health Literacy Scale (THLS-32) was used to assess health literacy. In order to determine the women's prenatal care knowledge levels, a total of 20 knowledge-testing statements prepared using the literature were applied, 14 of which were true and six of which were false. The internal consistency of antenatal information questions during pregnancy was made and the Cronbach alpha coefficient was calculated as 0.77. It was determined that 33.9% of the participants had a sufficient level of health literacy. Health literacy was sufficient in young married women (19 years and less) in their first pregnancy and those who had regular reading habits, participated in healthcare activities and received postpartum care at a family health clinic (p < 0.05 for each). While the most accurately evaluated statement about antenatal care was ‘It is normal to experience nausea/vomiting in the first trimester of pregnancy’, the least accurately evaluated statement was ‘Over 35% of women incorrectly believed it was normal to gain 20 kg of weight during pregnancy’. It was found that pregnant women with sufficient health literacy had higher levels of knowledge about antenatal care (p < 0.05). In this study, it was determined that approximately two-thirds of the participants had insufficient health literacy and the women with insufficient health literacy had low levels of knowledge about antenatal care.