首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   7015篇
  免费   567篇
  国内免费   9篇
耳鼻咽喉   62篇
儿科学   134篇
妇产科学   192篇
基础医学   1218篇
口腔科学   285篇
临床医学   634篇
内科学   1267篇
皮肤病学   269篇
神经病学   983篇
特种医学   251篇
外科学   664篇
综合类   62篇
一般理论   6篇
预防医学   457篇
眼科学   187篇
药学   406篇
中国医学   8篇
肿瘤学   506篇
  2024年   21篇
  2023年   117篇
  2022年   185篇
  2021年   267篇
  2020年   184篇
  2019年   250篇
  2018年   281篇
  2017年   225篇
  2016年   278篇
  2015年   285篇
  2014年   315篇
  2013年   370篇
  2012年   584篇
  2011年   568篇
  2010年   292篇
  2009年   257篇
  2008年   374篇
  2007年   334篇
  2006年   343篇
  2005年   328篇
  2004年   246篇
  2003年   247篇
  2002年   202篇
  2001年   61篇
  2000年   77篇
  1999年   53篇
  1998年   37篇
  1997年   53篇
  1996年   31篇
  1995年   25篇
  1994年   36篇
  1992年   34篇
  1991年   46篇
  1990年   40篇
  1989年   37篇
  1988年   33篇
  1987年   31篇
  1986年   39篇
  1985年   22篇
  1984年   18篇
  1983年   26篇
  1982年   18篇
  1981年   18篇
  1979年   25篇
  1977年   18篇
  1975年   31篇
  1974年   20篇
  1972年   25篇
  1971年   21篇
  1969年   19篇
排序方式: 共有7591条查询结果,搜索用时 31 毫秒
321.

Introduction

Cone-beam computed tomographic (CBCT) imaging is a valuable tool for endodontic therapy. The aim of this study was to verify whether clinical use of CBCT imaging can accurately acquire parameters concerning molar pulp chamber landmarks, which are important data to help start a successful access cavity and avoid iatrogenic furcation perforations.

Methods

Seventy CBCT images were used to measure 118 maxillary and 104 mandibular molars. The following vertical distances were measured: from the cusp tip/central fossa to the pulp chamber floor, to the pulp chamber ceiling, and to furcation; from the pulp chamber ceiling to furcation; from the pulp chamber floor to furcation; and the pulp chamber height. Measurements were read to the nearest 0.05 mm.

Results

The measurements were as follows: the pulp chamber floor to furcation (maxillary molar: 1.97 ± 0.58 [mean ± standard deviation, mm], mandibular molar: 2.24 ± 0.47), the pulp chamber ceiling to furcation (maxillary molar: 4.09 ± 0.68, mandibular molar: 3.78 ± 0.70), the central fossa to furcation (maxillary molar: 8.78 ± 0.79, mandibular molar: 8.53 ± 0.65), the central fossa to the pulp chamber floor (maxillary molar: 6.81 ± 0.83, mandibular molar: 6.29 ± 0.65), the central fossa to the pulp chamber ceiling (maxillary molar: 4.69 ± 0.59, mandibular molar: 4.75 ± 0.56); and pulp chamber height (maxillary molar: 2.12 ± 0.81, mandibular molar: 1.53 ± 0.68). Measurements showing the least standard deviation were the central fossa to furcation and the central fossa to the pulp chamber floor.

Conclusions

CBCT imaging may be used for precise clinical acquisition of the pulp chamber landmark measurements for molars thereby facilitating successful access cavity.  相似文献   
322.

Objectives

Constituents of dental composites can be released from dental fillings after polymerization. The aim of this study was to examine the time-related elution and breakdown of separable constituents of polymerized composites using deuterated solvents.

Method

Elution and breakdown of constituents were investigated with deuterated solvents methanol and water by gas chromatography/mass spectrometry of following composites for 180 days: Filtek™ Supreme XT, Filtek™ Supreme XT Flow, Tetric Ceram®, Tetric Flow®, Grandio®, Grandio® Flow.

Results

Within 180 days no compounds were formed as the products of breakdown. 19 compounds were identified as elution products: Bis-EMA, TEGDMA, DDDMA, EGDMA, MAA, BPA, CQ, HQME, DMABEE, CSA, BL, TEG, BHT, TINP, TPP, TPSB, DEDHTP, DCHP, ß-PHEA.The highest concentration of Bis-EMA was measured for Tetric Flow® in deuterated methanol on day 90 at 36.993 mmol/l and in deuterated water also on day 90 at 0.031 mmol/l.The highest TEGDMA concentrations were measured for Grandio® Flow in deuterated methanol on day 60 at 1.322 mmol/l and for Filtek™ Supreme XT Flow in deuterated water on day 3 at 0.689 mmol/l. The highest BPA concentration was measured for Tetric Flow® in deuterated methanol on day 90 at 1.469 mmol/l. The highest BPA concentration was measured for Grandio® in deuterated water on day 180 at 0.007 mmol/l.Significance Examination of time-related elution indicates that various elution products (e.g. Bis-EMA, BPA) were only released in small quantities during the first 90 days, but in high quantities between day 90 and day 180.  相似文献   
323.
Stafne bone cavities are usually found in men 50–70 years old. Typically they appear as lingual, open, ovoid lesions of the molar region of the lower jaw, and most contain parts of the submandibular gland. We have retrospectively examined panoramic radiographs acquired over a 5-year period. All lesions suspected of being Stafne bone cavities were included and analysed further to retrieve statistical information and derive a systematic diagnostic algorithm. We identified 21 Stafne bone cavities among 2928 patients (0.7%). Four of these were confirmed on cone-beam computed tomography (CT). One patient had magnetic resonance imaging (MRI) to confirm the diagnosis. The M:F ratio was 14:7 and the mean age 53 years (range 22–82). All cavities were located in the posterior mandible, 9 on the right and 12 on the left. The mean length was 10.9 (range 4.5–23) mm and height 5.7 (range 3.3–17.3) mm. All cavities were located in the posterior mandible. Sixteen panoramic radiographs (0.6%) were classified as possibly having a Stafne bone cavity but did not fulfil enough criteria to confirm the diagnosis. These 16 were not further analysed. It is rare to diagnose a Stafne bone cavity on a panoramic radiograph. Thorough investigation is essential to exclude differential diagnoses such as keratocystic odontogenic tumour, ameloblastoma, or a metastasis.  相似文献   
324.
The impact of the heating rate on the Ni content at the surface of the oxide layer of biomedical NiTi is explored. Heat treatment emulating common shape-setting procedures was performed by means of conventional and inductive heating for similar annealing time and temperature, applying various heating rates from ∼0.25 K s−1 to 250 K s−1. A glow discharge optical emission spectroscopy method was established and employed to evaluate concentration profiles of Ni, Ti and O in the near-surface region at high resolution. The Ni content at the surface of the differently treated samples varies significantly, with maximum surface Ni concentrations of ∼20 at.% at the lowest and ∼1.5 at.% at the highest heating rate, i.e. the total amount of Ni contained in the surface region of the oxide layer decreases by >15 times. Consequently, the heating rate is a determinant for the biomedical characteristics of NiTi, especially since Ni available at the surface of the oxide layer may affect the hemocompatibility and be released promptly after surgical application of a respective implant. Furthermore, apparently contradictory results presented in the literature reporting surface Ni concentrations of ∼3 at.% to >20 at.% after heat treatment are consistently explained considering the ascertained effect of the heating rate.  相似文献   
325.

Objectives

The purpose of this prospective clinical study was to identify the bacterial spectra on the surface of oral squamous cell carcinomas (OSCC) in comparison to oral mucosa of patients with a higher risk to emerge an OSCC and a control group to determine their susceptibility to various common antibiotics.

Material and methods

Swabs from 90 patients, 30 patients of each group, were cultured on media for aerobes and anaerobes and tested with agar diffusion and Etest.

Results

The predominant pathogens of the normal healthy oral mucosa were aerobes. The ratio between aerobes and anaerobes was 2:1, balanced in risk patients and inverted in the OSCC group. Altogether, 1,006 isolates were cultured. The most frequent strains were 47 viridans streptococci, 30 Staphylococcus species, 14 Enterococcus faecalis, 36 Neisseria species, 14 Escherichia coli, and 23 other aerobes, 66 Peptostreptococcus species, 39 Fusobacterium species, and 34 Prevotella species. The resistance rates in the OSCC group were penicillin 40 %, ampicillin 57 %, doxycycline 23 %, clindamycin 47 %, and amoxicillin/clavulanic acid 20 %, but up to 100 % of pathogens were susceptible to azithromycin, telithromycin, levofloxacin, and moxifloxacin.

Conclusion

Gram-negative anaerobes play a decisive role in the development of postoperative infections in patients with OSCC. This tumor special type of colonization does not agree with the normal flora of the oral cavity. Clinical relevance: Biofilms on OSCC surfaces provide an important reservoir for anaerobic bacteria. As a consequence, a proposal for an antibiotic prophylactic regime should be given.  相似文献   
326.

Objectives

The aim of this study was to assess the diagnostic performance and accuracy of four plaque indices for orthodontic patients.

Materials and methods

The plaque accumulation of 140 maxillary incisors with bonded brackets was recorded using intra-oral photographs and assessed using four different plaque indices: the orthodontic plaque (OP) index, the modified orthodontic plaque (MOP) index, the Quigley and Hein (QHP) index and the modified Navy plaque (MNP) index. The assessment was performed twice within a time interval of 4 weeks by four different examiner groups: orthodontists, dentists, students and orthodontic assistants.

Results

No significant differences were detected for the OP and MOP indices among the examiner groups. A significant difference was found for the QHP and MNP indices. The inter- and intra-examiner reliability of the OP and MOP indices was good. In contrast, the reliability for the QHP and MNP indices was moderate to poor with few exceptions. The discrimination performance of the OP and MOP indices was excellent. The sum of the sensitivity and specificity was generally lower for the QHP and MNP indices compared with the OP and MOP indices.

Conclusion

OP and MOP indices showed good performance. The QHP and MNP indices are not appropriate for orthodontic purposes.

Clinical relevance

Traditional plaque indices reflect the typical pattern of plaque accumulation for patients without multi-bracket appliances. The performance of these indices for orthodontic patients has never been investigated. Orthodontic plaque indices that focus on the surface along the gingival margin and areas around the bracket exhibit higher diagnostic performance and accuracy compared with traditional indices.  相似文献   
327.
328.
329.
330.
This paper addresses the importance of correctly classifying eating disordered patients as to their weight. There seems to be no consistent approach to classification using the three most commonly used weight classification schemes: the Metropolitan Life Insurance Company tables of 1959 and 1983 and the DHEW weight tables of 1978. These three tables are discussed relative to their use in the classification of subjects as underweight, normal weight, or overweight. The tables and their various adjustments for heel height, clothing weight, and age are applied to 87 female patients coming to an eating disorder clinic. The percentage of subjects who were classified as underweight (range 16–71%), normal weight (range 25–51%), and overweight (range 3–33%) varied dramatically between tables and within tables using different applications. Differences between the tables based on height and age are discussed. Suggestions are made about the correct derivation and reporting of weight classification of subjects in research studies.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号