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51.
JP Ortonne† HC Korting‡ C Viguié-Vallanet§ C Larnier¶ E Savaluny¶ 《Journal of the European Academy of Dermatology and Venereology》2006,20(10):1307-1313
BACKGROUND: Tinea pedis is a common dermatophyte infection with frequent recurrences. Terbinafine (presently used as a 1-week topical treatment of tinea pedis) is now available in a novel topical solution (film-forming solution--FFS), developed to allow single application. OBJECTIVES: To demonstrate the efficacy and safety of terbinafine 1% FFS in a randomized, double-blind, placebo-controlled, phase III trial, and to determine relapse or re-infection rate of tinea pedis at 12 weeks. PATIENTS/METHODS: Fifty-four centres (27 in France; 27 in Germany) enrolled 273 evaluable patients (2 : 1 randomization). Patients applied terbinafine 1% FFS or placebo only once between, under and over the toes, soles and sides of both feet. Efficacy assessments included direct microscopy, mycological culture, and clinical signs and symptoms at baseline, and at weeks 1, 6 and 12 after the single drug application. RESULTS: Effective treatment (negative mycology plus absent/minimal symptoms) at week 6 in the terbinafine 1% FFS group was 63%; vehicle was 17% (P相似文献
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Organophosphate insecticides, such as Vapona, Naled, and Rabon, are highly potent inhibitors of an enzyme found in human monocytes. The enzyme, a specific monocyte esterase, could be inhibited by Vapona in blood samples via airborne contamination at levels easily achieved from commercial slow-release insecticide strips. Fifty percent inhibition (I50)--as measured on the Hemalog D (Technicon Corp.)--occurred at solution concentrations of 0.22, 1.5, and 2.6 X 10(-6) g/liter for Vapona, Rabon, and Naled, respectively. Parathion (a thiophosphate) and Baygon (a carbamate) were less potent, with I50 values of 3.7 X 10(-5) and 1.5 X 10(-4) g/liter, respectively. Dursban (another thiophosphate) and Carbaryl (a carbamate) showed only marginal inhibition. Eserine, malathion, nicotine and pyrethrum had no inhibitory effect up to 0.5 g/liter. The occurrence of this effect in vivo has not yet been shown, nor is it clear what the implications of such an effect would be. The inhibition of this enzyme by airborne contaminants, however, may interfere with the proper functioning of the Hemalog D. 相似文献
57.
Congenital left ventricular aneurysm: clinical, imaging, pathologic, and surgical findings in seven new cases 总被引:5,自引:0,他引:5
Papagiannis J Van Praagh R Schwint O D'Orsogna L Qureshi F Reynolds J Kallfelz C Nozar J 《American heart journal》2001,141(3):491-499
BACKGROUND: Congenital left ventricular aneurysm is a poorly understood and potentially lethal entity.Methods and Results In a clinicopathologic study of 7 new cases, the major presenting features in 6 patients were congestive heart failure in 4, ventricular arrhythmias in a 32-week fetus, and multiple congenital anomalies in a fetus with trisomy 13. Accurate diagnosis was achieved in all 3 living patients by echocardiography, angiocardiography, and magnetic resonance imaging. The aneurysm was predominantly apical in 3 and involved most of the left ventricular free wall in 4. Of the 3 living patients, medical management alone sufficed in 2. The third, a newborn boy, underwent a new and successful aneurysm-exclusion left ventriculoplasty. The mitral valve was abnormal in all 4 autopsied cases, the papillary muscles being short, thin, or absent. The aneurysm was thinner and its area was larger than that of the nonaneurysmal left ventricle in all necropsied patients. CONCLUSIONS: Congenital left ventricular aneurysm appears to be a developmental anomaly, an idiopathic dysplasia of left ventricular endocardium and myocardium. No evidence of a viral etiology was found. Some neonates can be managed medically, but others require urgent surgical intervention. A new surgical operation is presented, a functional left ventricular aneurysmectomy that minimizes intraoperative and postoperative blood loss and that preserves the coronary arteries. 相似文献
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Damario MA; Barmat L; Liu HC; Davis OK; Rosenwaks Z 《Human reproduction (Oxford, England)》1997,12(11):2359-2365
Certain patients have a tendency for high response to gonadotrophin therapy
which is often not ameliorated with prior gonadotrophin- releasing hormone
agonist (GnRHa) suppression. As a result, these patients are frequently
cancelled and often experience ovarian hyperstimulation syndrome (OHSS)
episodes during in-vitro fertilization (IVF)-embryo transfer cycles.
Patients with polycystic ovarian syndrome (PCOS) have been noted to be
particularly sensitive to exogenous gonadotrophin therapy. We have
developed a protocol which is effective in improving IVF outcome in high
responder patients, including those with PCOS. Oral contraceptive pills
(OCP) are taken for 25 days followed by s.c. leuprolide acetate, 1 mg/day,
which is overlapped with the final 5 days of oral contraceptive
administration. Low-dose gonadotrophin stimulation is then initiated on the
third day of withdrawal bleeding in the form of either human menopausal
gonadotrophins or purified urinary follicle-stimulating hormone at a dosage
of 150 IU/day. Over a 5 year period, we reviewed our experience utilizing
this dual method of suppression in 99 cycles obtained in 73 high responder
patients. There were only 13 cancellations prior to embryo transfer
(13.1%). The clinical and ongoing pregnancy rates per initiated cycle were
46.5 and 40.4% respectively. Only eight patients experienced mild-moderate
OHSS following treatment. For those patients who had undergone previous
IVF-embryo transfer cycles at our centre, significant improvements were
noted in oocyte fertilization rates, embryo implantation rates and
clinical/ongoing pregnancy rates with this protocol. Hormonal analyses
revealed that the chief mechanism may be through an improved luteinizing
hormone/follicle-stimulating hormone ratio following dual suppression. An
additional feature of this dual method of suppression is significantly
lower serum androgen concentrations, particularly dehydroepiandrosterone
sulphate.
相似文献
60.
G Frank D Baumgart H Klein I Luhmer D Lowes H C Kallfelz H G Borst 《Zeitschrift für Kardiologie》1987,76(2):118-123
Focal atrial tachycardia with frequencies up to 200/min in an 11-year-old girl had been resistant to drugs over a period of 5 years. An electrophysiological study demonstrated a left atrial ectopic tachycardia. Intraoperative epicardial mapping localized the automatic focus at the base of the left atrial appendage. Excision of the appendage and cryoablation of the adjacent area were performed using cardiopulmonary bypass. Histological examination of the excised tissue showed no specific alterations aside from islets of fatty tissue. The girl has been in sinus rhythm and has shown no tachycardias during the 6 months following the operation. Review of the literature covering 17 cases of right and 12 cases of left atrial focal tachycardia indicates excision of the atrial tissue in combination with cryoablation to be the treatment of choice to ensure success. 相似文献