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排序方式: 共有95条查询结果,搜索用时 15 毫秒
71.
Marius Wunderle Paul Gass Lothar Häberle Vivien M. Flesch Claudia Rauh Mayada R. Bani Carolin C. Hack Michael G. Schrauder Sebastian M. Jud Julius Emons Ramona Erber Arif B. Ekici Juliane Hoyer Georgia Vasileiou Cornelia Kraus Andre Reis Arndt Hartmann Michael P. Lux Matthias W. Beckmann Peter A. Fasching Alexander Hein 《Breast cancer research and treatment》2018,171(1):85-94
Purpose
BRCA1/2 mutations influence the molecular characteristics and the effects of systemic treatment of breast cancer. This study investigates the impact of germline BRCA1/2 mutations on pathological complete response and prognosis in patients receiving neoadjuvant systemic chemotherapy.Methods
Breast cancer patients were tested for a BRCA1/2 mutation in clinical routine work and were treated with anthracycline-based or platinum-based neoadjuvant chemotherapy between 1997 and 2015. These patients were identified in the tumor registry of the Breast Center of the University of Erlangen (Germany). Logistic regression and Cox regression analyses were performed to investigate the associations between BRCA1/2 mutation status, pathological complete response, disease-free survival, and overall survival.Results
Among 355 patients, 59 had a mutation in BRCA1 or in BRCA2 (16.6%), 43 in BRCA1 (12.1%), and 16 in BRCA2 (4.5%). Pathological complete response defined as “ypT0; ypN0” was observed in 54.3% of BRCA1/2 mutation carriers, but only in 22.6% of non-carriers. The adjusted odds ratio was 2.48 (95% CI 1.26–4.91) for BRCA1/2 carriers versus non-carriers. Patients who achieved a pathological complete response had better disease-free survival and overall survival rates compared with those who did not achieve a pathological complete response, regardless of BRCA1/2 mutation status.Conclusions
BRCA1/2 mutation status leads to better responses to neoadjuvant chemotherapy in breast cancer. Pathological complete response is the main predictor of disease-free survival and overall survival, independently of BRCA1/2 mutation status.72.
Judé S Martel E Vincent F Besson P Couet C Ogilvie GK Pinault M De Chalendar C Bougnoux P Richard S Champeroux P Crozatier B Le Guennec JY 《The British journal of nutrition》2007,98(6):1143-1151
The effects of an n-3 PUFA-enriched diet on cardiac cell membrane phospholipid fraction compositions and associated protein kinase-C (PKC) translocation modification have never been studied in higher mammals. This is of importance since membrane fatty acid composition has been shown to influence PKC signalling pathways. In the present study, we have tested whether the incorporation of n-3 PUFA in cardiac membrane phospholipids correlated with changes in the fatty acid composition of diacylglycerols (DAG) and led to a differential translocation of PKC isoforms. Two groups of five dogs were fed the standard diet supplemented with palm oil or fish oil for 8 weeks. Dogs fed a fish oil-enriched diet showed a preferential incorporation of EPA and, to a lesser extent, of DHA, at the expense of arachidonic acid, in the circulating TAG, plasma phospholipids, erythrocyte phospholipids and cardiomyocyte phospholipid fractions. Analysis of 1,2-DAG fatty acid composition also indicated a preferential enrichment of EPA compared with DHA. Associated with these results, a reduction in the expression of PKC-delta and PKC-epsilon isoforms in the particulate fractions was observed whereas no effect was seen for PKC-alpha and PKC-zeta. We conclude that a fish oil-enriched diet induces a modification in fatty acid composition of cardiac membrane phospholipids, associated with a differential translocation of PKC isoforms. These results can be explained by the production of structurally different DAG that may participate in some of the protective effects of n-3 PUFA against various chronic diseases. 相似文献
73.
Prof. Dr. R. Schulz-Wendtland T. Wittenberg T. Michel A. Hartmann M.W. Beckmann C. Rauh S.M. Jud B. Brehm M. Meier-Meitinger G. Anton M. Uder P.A. Fasching 《Der Radiologe》2014,54(3):217-223
Mammography is the central diagnostic method for clinical diagnostics of breast cancer and the breast cancer screening program. In the clinical routine complementary methods, such as ultrasound, tomosynthesis and optional magnetic resonance imaging (MRI) are already combined for the diagnostic procedure. Future developments will utilize investigative procedures either as a hybrid (combination of several different imaging modalities in one instrument) or as a fusion method (the technical fusion of two or more of these methods) to implement fusion imaging into diagnostic algorithms. For screening there are reasonable hypotheses to aim for studies that individualize the diagnostic process within the screening procedure. Individual breast cancer risk prediction and individualized knowledge about sensitivity and specificity for certain diagnostic methods could be tested. The clinical implementation of these algorithms is not yet in sight. 相似文献
74.
75.
Vachon CM Scott CG Fasching PA Hall P Tamimi RM Li J Stone J Apicella C Odefrey F Gierach GL Jud SM Heusinger K Beckmann MW Pollan M Fernández-Navarro P Gonzalez-Neira A Benitez J van Gils CH Lokate M Onland-Moret NC Peeters PH Brown J Leyland J Varghese JS Easton DF Thompson DJ Luben RN Warren RM Wareham NJ Loos RJ Khaw KT Ursin G Lee E Gayther SA Ramus SJ Eeles RA Leach MO Kwan-Lim G Couch FJ Giles GG Baglietto L Krishnan K Southey MC Le Marchand L Kolonel LN Woolcott C Maskarinec G Haiman CA 《Cancer epidemiology, biomarkers & prevention》2012,21(7):1156-1166
76.
Staller JA 《The American journal of orthopsychiatry》2006,76(1):98-102
Outpatient child psychiatrists appear to be treating a broadening array of complex, highly comorbid, and difficult-to-treat youths. In this study, designed to evaluate the current demographic and diagnostic profile of outpatient child psychiatric patients 1,292 outpatient records from 8 treatment settings were reviewed. Patient age, race, gender, and diagnoses were recorded and analyzed. Externalizing disorders (ADHD and/or behavior disorders) were diagnosed most frequently, followed by internalizing (depressive and anxiety) disorders. Comorbidity was evident in nearly half of all patients, regardless of age. Substance abuse was infrequently reported as a comorbid condition. Externalizing and internalizing pathology frequently co-occurred. Findings reinforce the need for clinician vigilance and thorough assessment of outpatient children and adolescents. 相似文献
77.
Cajochen C Jud C Münch M Kobialka S Wirz-Justice A Albrecht U 《The European journal of neuroscience》2006,23(4):1082-1086
We developed a non-invasive method to measure and quantify human circadian PER2 gene expression in oral mucosa samples and show that this gene oscillates in a circadian (= about a day) fashion. We also have the first evidence that induction of human PER2 expression is stimulated by exposing subjects to 2 h of light in the evening. This increase in PER2 expression was statistically significant in comparison to a non-light control condition only after light at 460 nm (blue) but not after light exposure at 550 nm (green). Our results indicate that the non-image-forming visual system is involved in human circadian gene expression. The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders. 相似文献
78.
Jud W Gurney 《AJR. American journal of roentgenology》2002,178(1):41-45
OBJECTIVE: The purpose of this study was to index the contents of the pre-MEDLINE American Journal of Roentgenology into a database that could then be accessed over the World Wide Web. CONCLUSION: The database is composed of more than 8,000 citations from the years 1914 (volume 1) to 1965 (volume 95). Using a Web browser, a user can search the database by year, volume, title word, page, or author. Results are returned sorted by year and page number in a bibliographic format. The database is accessed approximately 200 times per month. 相似文献
79.
Mammographic density is the main correlate of tumors detected on ultrasound but not on mammography 下载免费PDF全文
Lothar Häberle Peter A. Fasching Barbara Brehm Katharina Heusinger Sebastian M. Jud Christian R. Loehberg Carolin C. Hack Caroline Preuss Michael P. Lux Arndt Hartmann Celine M. Vachon Martina Meier‐Meitinger Michael Uder Matthias W. Beckmann Rüdiger Schulz‐Wendtland 《International journal of cancer. Journal international du cancer》2016,139(9):1967-1974
Although mammography screening programs do not include ultrasound examinations, some diagnostic units do provide women with both mammography and ultrasonography. This article is concerned with estimating the risk of a breast cancer patient diagnosed in a hospital‐based mammography unit having a tumor that is visible on ultrasound but not on mammography. A total of 1,399 women with invasive breast cancer from a hospital‐based diagnostic mammography unit were included in this retrospective study. For inclusion, mammograms from the time of the primary diagnosis had to be available for computer‐assisted assessment of percentage mammographic density (PMD), as well as Breast Imaging Reporting and Data System (BIRADS) assessment of mammography. In addition, ultrasound findings were available for the complete cohort as part of routine diagnostic procedures, regardless of any patient or imaging characteristics. Logistic regression analyses were conducted to identify predictors of mammography failure, defined as BIRADS assessment 1 or 2. The probability that the visibility of a tumor might be masked at diagnosis was estimated using a regression model with the identified predictors. Tumors were only visible on ultrasound in 107 cases (7.6%). PMD was the strongest predictor for mammography failure, but age, body mass index and previous breast surgery also influenced the risk, independently of the PMD. Risk probabilities ranged from 1% for a defined low‐risk group up to 40% for a high‐risk group. These findings might help identify women who should be offered ultrasound examinations in addition to mammography. 相似文献
80.
Johannes Lermann Petra Segl Sebastian M. Jud Matthias W. Beckmann Peter Oppelt Falk C. Thiel Stefan P. Renner Andreas Müller 《Archives of gynecology and obstetrics》2014,289(2):329-335