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91.
92.
M. Jiménez-Mejías C. Pichardo-Guerrero F. Márquez-Rivas D. Martín-Lozano T. Prados J. Pachón 《European journal of clinical microbiology & infectious diseases》2002,21(3):212-214
Described here is a case of meningitis caused by multidrug-resistant Acinetobacter baumannii susceptible only to colistin, which was treated successfully with intravenous colistin sulfomethate sodium (5 mg/kg/day).
The levels of colistin in serum and cerebrospinal fluid and the pharmacokinetic/pharmacodynamic parameters of colistin were
determined. In this case, intravenously administered colistin penetrated cerebrospinal fluid (25% of serum levels) at levels
sustaining bactericidal concentrations.
Electronic Publication 相似文献
93.
A Sánchez-Picó J E Peris-Ribera C Toledano F Torres-Molina V G Casabó A Martín-Villodre J M Plá-Delfina 《The Journal of pharmacy and pharmacology》1989,41(3):179-185
Absorption of cefadroxil in a selective intestinal absorption area (the proximal third of the small intestine) of the anaesthetized rat, at seven initial perfusion concentrations, ranging from 0.01 to 10.0 mg mL-1, is shown to be a non-linear transport mechanism. With the aid of computer-fitting procedures based on differential and integrated forms of Michaelis-Menten equation, Vm and Km values of 36.7-37.3 mg h-1 and 12.0-13.0 mg, respectively, were found. The statistical parameters were better than those obtained both for first-order and for combined Michaelis-Menten and first-order kinetics. There is no evidence for substantial passive diffusion processes. The results reported here, together with allometric considerations and literature data analysis, may help to explain some particular non-linear features of plasma level curves associated with the administration of fairly high oral doses of cefadroxil to humans. 相似文献
94.
95.
96.
M Goihman-Yahr J Pereira G Istúriz N Viloria M Carrasquero N Saavedra M H de Gómez A Román B San Martín M C Bastardo de Albornoz 《Mycoses》1992,35(11-12):269-274
Peripheral blood neutrophils (PMN) from patients with paracoccidioidomycosis killed and digested Paracoccidioides brasiliensis much less than did PMN from normal individuals or from patients with other diseases. However, deficiency in killing ability was less specific than digestive deficiency and correlated poorly with it. We conclude that the capacities of PMN to digest and kill P. brasiliensis are not intimately related phenomena, and that in paracoccidioidomycosis the key deficiency of neutrophil function is that of digestion of P. brasiliensis. 相似文献
97.
Fernando Regla Vargas Jos Carlos Cabral de Almeida Juan Clinton Llerena Dimas Fagundes Reis 《American journal of medical genetics. Part A》1992,44(6):716-719
We report on a boy with severe radial hypoplasia, absent thumbs and patellae, short stature, persistent diarrhea, slender nose and normal intelligence as another example of the RAPADILINO syndrome. © 1992 Wiley-Liss, Inc. 相似文献
98.
C A Mestres M Acosta C Paré R Carta?á A Martínez J L Pomar 《Revista espa?ola de cardiología》1991,44(6):408-410
Minor experience still exists in our country with regard to the use of valve homografts in cardiac surgery. Only a few implantations have been performed in cases of right ventricular outflow tract reconstruction in addition to our own experience in cases of infective endocarditis of the aortic valve. We present a case of aortic valve replacement by using an antibiotic-sterilized fresh pulmonary valve autograft. The case is described and the possible advantages of the use of pulmonary allografts in the aortic position are discussed. 相似文献
99.
María de Gracia García-Martín María Violante de Paz Juan Antonio Galbis 《Macromolecular chemistry and physics.》1997,198(1):219-227
A chiral poly(3-substituted isobutyl D -aspartate) 12 was synthesized by polymerization of the chiral β-lactam 11 derived from D -glyceraldehyde. The new polyamide was characterized by elemental analyses, and infrared, 1H- and 13C nuclear magnetic resonance spectroscopies. The molecular weight was estimated as 543 000 and 230 000 on the basis of viscosimetric measurements and gel-permeation chromatography, respectively. Polyamide 12 is soluble in a variety of organic solvents including chloroform. 相似文献
100.
胶束电动毛细管色谱法测定复方酮康唑霜中酮康唑和特美呋的含量 总被引:1,自引:0,他引:1
目的:毛细管电泳法测定酮康唑霜中酮康唑和特美味的含量。方法:分离缓冲液为胆汁酸钠(70 mmol/L)-三羟甲基氨基甲烷-磷酸(50 mmol/L)(pH 8.14),分离电压30 kV、温度25 C、50 μm(内径)×48.5cm(有效长度40cm)空心熔融石英毛细管柱、检测波长240nm。结果:以丙酸睾酮为内标,酮康唑质量浓度在140.5~702.5 μg/ml、特美呋质量浓度在151~755μg/ml之间成良好的线性关系;加样回收率分别为95.4%~103.9%、95.9%~102.6%,RSD%分别为2.8%~4.2%(n=3)、2.9%~3.6%。结论:本法简便、快速、可靠,可用于该复方制剂中酮康唑及特美呋的含量测定。 相似文献