全文获取类型
| 收费全文 | 424218篇 |
| 免费 | 13166篇 |
| 国内免费 | 457篇 |
专业分类
| 耳鼻咽喉 | 4503篇 |
| 儿科学 | 14184篇 |
| 妇产科学 | 8043篇 |
| 基础医学 | 52024篇 |
| 口腔科学 | 8090篇 |
| 临床医学 | 31809篇 |
| 内科学 | 87002篇 |
| 皮肤病学 | 7300篇 |
| 神经病学 | 38506篇 |
| 特种医学 | 16004篇 |
| 外国民族医学 | 101篇 |
| 外科学 | 59656篇 |
| 综合类 | 3337篇 |
| 一般理论 | 75篇 |
| 预防医学 | 40466篇 |
| 眼科学 | 7698篇 |
| 药学 | 27097篇 |
| 中国医学 | 1410篇 |
| 肿瘤学 | 30536篇 |
出版年
| 2023年 | 1406篇 |
| 2022年 | 954篇 |
| 2021年 | 3933篇 |
| 2020年 | 2321篇 |
| 2019年 | 4449篇 |
| 2018年 | 29269篇 |
| 2017年 | 21857篇 |
| 2016年 | 23993篇 |
| 2015年 | 7148篇 |
| 2014年 | 7340篇 |
| 2013年 | 11301篇 |
| 2012年 | 24719篇 |
| 2011年 | 37959篇 |
| 2010年 | 27057篇 |
| 2009年 | 17819篇 |
| 2008年 | 33920篇 |
| 2007年 | 37056篇 |
| 2006年 | 15730篇 |
| 2005年 | 17128篇 |
| 2004年 | 17235篇 |
| 2003年 | 16917篇 |
| 2002年 | 14357篇 |
| 2001年 | 6453篇 |
| 2000年 | 6685篇 |
| 1999年 | 5766篇 |
| 1998年 | 1168篇 |
| 1997年 | 1001篇 |
| 1996年 | 856篇 |
| 1995年 | 802篇 |
| 1992年 | 3268篇 |
| 1991年 | 2990篇 |
| 1990年 | 2875篇 |
| 1989年 | 2591篇 |
| 1988年 | 2435篇 |
| 1987年 | 2246篇 |
| 1986年 | 2125篇 |
| 1985年 | 1929篇 |
| 1984年 | 1441篇 |
| 1983年 | 1224篇 |
| 1979年 | 1215篇 |
| 1978年 | 862篇 |
| 1977年 | 804篇 |
| 1975年 | 816篇 |
| 1974年 | 1014篇 |
| 1973年 | 1001篇 |
| 1972年 | 936篇 |
| 1971年 | 927篇 |
| 1970年 | 881篇 |
| 1969年 | 929篇 |
| 1968年 | 806篇 |
排序方式： 共有10000条查询结果，搜索用时 0 毫秒
71.
Giorgio Gandaglia Guillaume Ploussard Massimo Valerio Agostino Mattei Cristian Fiori Nicola Fossati Armando Stabile Jean-Baptiste Beauval Bernard Malavaud Mathieu Roumiguié Daniele Robesti Paolo Dell’Oglio Marco Moschini Stefania Zamboni Arnas Rakauskas Francesco De Cobelli Francesco Porpiglia Francesco Montorsi Alberto Briganti 《European urology》2019,75(3):506-514
Background
Available models for predicting lymph node invasion (LNI) in prostate cancer (PCa) patients undergoing radical prostatectomy (RP) might not be applicable to men diagnosed via magnetic resonance imaging (MRI)-targeted biopsies.Objective
To assess the accuracy of available tools to predict LNI and to develop a novel model for men diagnosed via MRI-targeted biopsies.Design, setting, and participants
A total of 497 patients diagnosed via MRI-targeted biopsies and treated with RP and extended pelvic lymph node dissection (ePLND) at five institutions were retrospectively identified.Outcome measurements and statistical analyses
Three available models predicting LNI were evaluated using the area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analyses. A nomogram predicting LNI was developed and internally validated.Results and limitations
Overall, 62 patients (12.5%) had LNI. The median number of nodes removed was 15. The AUC for the Briganti 2012, Briganti 2017, and MSKCC nomograms was 82%, 82%, and 81%, respectively, and their calibration characteristics were suboptimal. A model including PSA, clinical stage and maximum diameter of the index lesion on multiparametric MRI (mpMRI), grade group on targeted biopsy, and the presence of clinically significant PCa on concomitant systematic biopsy had an AUC of 86% and represented the basis for a coefficient-based nomogram. This tool exhibited a higher AUC and higher net benefit compared to available models developed using standard biopsies. Using a cutoff of 7%, 244 ePLNDs (57%) would be spared and a lower number of LNIs would be missed compared to available nomograms (1.6% vs 4.6% vs 4.5% vs 4.2% for the new nomogram vs Briganti 2012 vs Briganti 2017 vs MSKCC).Conclusions
Available models predicting LNI are characterized by suboptimal accuracy and clinical net benefit for patients diagnosed via MRI-targeted biopsies. A novel nomogram including mpMRI and MRI-targeted biopsy data should be used to identify candidates for ePLND in this setting.Patient summary
We developed the first nomogram to predict lymph node invasion (LNI) in prostate cancer patients diagnosed via magnetic resonance imaging-targeted biopsy undergoing radical prostatectomy. Adoption of this model to identify candidates for extended pelvic lymph node dissection could avoid up to 60% of these procedures at the cost of missing only 1.6% patients with LNI. 相似文献72.
Renaud Snanoudj Nassim Kamar Elisabeth Cassuto Sophie Caillard Marie Metzger Pierre Merville Antoine Thierry Isabelle Jollet Philippe Grimbert Dany Anglicheau Marc Hazzan Gabriel Choukroun Bruno Hurault De Ligny Bénedicte Janbon Vincent Vuiblet Anne Devys Yann Le Meur Michel Delahousse Jean-Luc Taupin 《Kidney international》2019,95(6):1471-1485
73.
74.
75.
76.
M. Masson Regnault J. Castañeda-Sanabria M.H.T. Diep Tran M. Beylot-Barry H. Bachelez N. Beneton O. Chosidow A. Dupuy P. Joly D. Jullien E. Mahé M.-A. Richard M. Viguier F. Tubach E. Sbidian C. Paul The PsoBioTeq Study Group 《Journal of the European Academy of Dermatology and Venereology》2020,34(2):293-300
77.
78.
79.
Béla Nagy Zsolt Bene Zsolt Fejes Sonya L. Heltshe David Reid Nicola J. Ronan Yvonne McCarthy Daniel Smith Attila Nagy Elizabeth Joseloff György Balla János Kappelmayer Milan Macek Scott C. Bell Barry J. Plant Margarida D. Amaral István Balogh 《Journal of cystic fibrosis》2019,18(2):271-277
Background
We have recently shown that human epididymis protein 4 (HE4) levels correlate with the severity of cystic fibrosis (CF) lung disease. However, there are no data on how HE4 levels alter in patients receiving CFTR modulating therapy.Methods
In this retrospective clinical study, 3 independent CF patient cohorts (US-American: 29, Australian: 12 and Irish: 19 cases) were enrolled carrying at least one Class III CFTR CF-causing mutation (p.Gly551Asp) and being treated with CFTR potentiator ivacaftor. Plasma HE4 was measured by immunoassay before treatment (baseline) and 1–6?months after commencement of ivacaftor, and were correlated with FEV1 (% predicted), sweat chloride, C-reactive protein (CRP) and body mass index (BMI).Results
After 1?month of therapy, HE4 levels were significantly lower than at baseline and remained decreased up to 6?months. A significant inverse correlation between absolute and delta values of HE4 and FEV1 (r?=??0.5376; P?<?.001 and r?=??0.3285; P?<?.001), was retrospectively observed in pooled groups, including an independent association of HE4 with FEV1 by multiple regression analysis (β?=??0.57, P?=?.019). Substantial area under the receiver operating characteristic curve (ROC-AUC) value was determined for HE4 when 7% mean change of FEV1 (0.722 [95% CI 0.581–0.863]; P?=?.029) were used as classifier, especially in the first 2?months of treatment (0.806 [95% CI 0.665–0.947]; P?<?.001).Conclusions
This study shows that plasma HE4 levels inversely correlate with lung function improvement in CF patients receiving ivacaftor. Overall, this potential biomarker may be of value for routine clinical and laboratory follow-up of CFTR modulating therapy. 相似文献80.
Modena Débora Aparecida Oliveira Miranda Ana Carolina Godoy Grecco Clovis Liebano Richard Eloin Cordeiro Raquel Cristina Tancsik Guidi Renata Michelini 《Lasers in medical science》2020,35(4):797-806
Lasers in Medical Science - Using light sources in phototherapy has presented promising results regarding several types of facial and body skin affections for centuries. The neodymium-doped yttrium... 相似文献