全文获取类型
收费全文 | 1652篇 |
免费 | 134篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 27篇 |
妇产科学 | 53篇 |
基础医学 | 448篇 |
口腔科学 | 7篇 |
临床医学 | 199篇 |
内科学 | 321篇 |
皮肤病学 | 20篇 |
神经病学 | 85篇 |
特种医学 | 37篇 |
外科学 | 274篇 |
综合类 | 7篇 |
一般理论 | 2篇 |
预防医学 | 102篇 |
眼科学 | 23篇 |
药学 | 107篇 |
肿瘤学 | 47篇 |
出版年
2023年 | 8篇 |
2022年 | 19篇 |
2021年 | 37篇 |
2020年 | 35篇 |
2019年 | 44篇 |
2018年 | 48篇 |
2017年 | 37篇 |
2016年 | 48篇 |
2015年 | 54篇 |
2014年 | 75篇 |
2013年 | 125篇 |
2012年 | 165篇 |
2011年 | 140篇 |
2010年 | 81篇 |
2009年 | 64篇 |
2008年 | 109篇 |
2007年 | 113篇 |
2006年 | 108篇 |
2005年 | 106篇 |
2004年 | 74篇 |
2003年 | 60篇 |
2002年 | 48篇 |
2001年 | 12篇 |
2000年 | 12篇 |
1999年 | 14篇 |
1998年 | 15篇 |
1997年 | 9篇 |
1996年 | 10篇 |
1995年 | 15篇 |
1994年 | 12篇 |
1993年 | 10篇 |
1992年 | 4篇 |
1991年 | 9篇 |
1990年 | 9篇 |
1989年 | 7篇 |
1988年 | 9篇 |
1987年 | 7篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1983年 | 2篇 |
1982年 | 6篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1969年 | 2篇 |
1933年 | 1篇 |
排序方式: 共有1795条查询结果,搜索用时 15 毫秒
31.
BackgroundThe increasing prevalence of obesity has resulted in an increased number of revision total hip arthroplasties (rTHAs) performed in patients with a high body mass index (BMI). The aim of this study is to evaluate whether obesity negatively affects (1) complication rate, (2) reoperation and revision rate, and (3) patient-reported outcome in rTHA.MethodsIn this registry-based study, we prospectively followed 444 rTHAs (cup: n = 265, stem: n = 57, both: n = 122) performed in a specialized high-volume orthopedic center between 2013 and 2015. The number of complications, and reoperation and revision surgery was registered until 5 years postoperatively. Oxford Hip Score (OHS) was evaluated preoperatively, and at 1 and 2 years postoperatively. Patients were categorized based on BMI to nonobese (<30 kg/m2, n = 328), obese (30-35 kg/m2, n = 82), and severe obese (≥35 kg/m2, n = 34).ResultsSevere obese patients, but not obese patients, had higher risks of complications and re-revision than nonobese patients. In particular, the risk of infection following rTHA was higher in severe obese patients (24%) compared to nonobese patients (3%; relative risk, 7.7). Severe obese patients had overall poorer OHS than nonobese patients, but improvement in OHS did not differ between severe obese and nonobese patients. No differences between obese and nonobese groups on OHS were observed.ConclusionIn our study, severe obesity was associated with an increased risk of infection following rTHA. Patients with high BMI should be counseled appropriately before surgery. 相似文献
32.
33.
Xavier Henry Oliver Verlaine Ana Amoroso Jacques Coyette Jean-Marie Frère Bernard Joris 《Antimicrobial agents and chemotherapy》2013,57(12):6358-6360
The opportunistic human pathogen Enterococcus faecium overproduces the low-affinity PBP5. In clinical strains, mutations in PBP5 further reduce its acylation rate by β-lactams. Previous studies have reported that ceftaroline had poor inhibitory activity against β-lactam-resistant E. faecium strains. In this study, we show that ceftaroline exhibits killing activity against our laboratory-derived ampicillin-resistant E. faecium mutant that overproduces a wild-type PBP5 and that ceftaroline inactivates PBP5 much faster than benzylpenicillin and faster than ceftobiprole. 相似文献
34.
A minority of patients with newly diagnosed polycythemia vera (PV) have an abnormal karyotype in their myeloid cells but no invariant chromosomal aberration has been found. The most frequent visible alteration is a 20q deletion, also characterized in other myeloproliferative diseases (MPD) and myeloid malignancies; among other chromosomal changes, trisomy 9 appears more common in PV than in other MPDs. When a myelofibrosis complicates the course of the disease, cytogenetic anomalies become quite common with a striking frequency of partial duplication 1q; an evolution towards myelodysplasia or acute leukemia is almost always associated with nonspecific chromosomal aberrations. Modern cytogenetic methods have disclosed cryptic anomalies and pointed out the high frequency of 9p alterations affecting a restricted region, thus stimulating an active search for candidate genes or specific mutations. 相似文献
35.
36.
Joris W J Vriend Wim Drenthen Petronella G Pieper Jolien W Roos-Hesselink Aeiko H Zwinderman Dirk J van Veldhuisen Barbara J M Mulder 《European heart journal》2005,26(20):2173-2178
AIMS: Nowadays, most women born with aortic coarctation reach childbearing age. However, data on outcome of pregnancy in women after repair of aortic coarctation are scarce. The aim of this study was to report on maternal and neonatal outcome of pregnancy in women after aortic coarctation repair. METHODS AND RESULTS: The CONCOR national registry on congenital heart disease in The Netherlands was reviewed for women of childbearing age (> or =18 years old) with a history of aortic coarctation repair. Medical history and maternal, obstetrical, and neonatal outcome were determined. Fifty-four of the 100 women included had a history of pregnancy. The 54 women had 126 pregnancies resulting in 98 successful pregnancies, 22 miscarriages, and six abortions. The success rate was estimated as 0.778 (SE 0.002) including abortions and 0.817 (SE 0.002) excluding abortions. There were 85 vaginal deliveries, seven vaginal deliveries with epidural analgesia, and six caesarean sections. There were two neonatal deaths. A total of 26 pregnancies were complicated by a hypertensive disorder of pregnancy. There were 21 pregnancies in 14 women complicated by hypertension and five pregnancies in four women complicated by pre-eclampsia. The hypertension- and pre-eclampsia-probabilities were estimated as 0.183 (SE 0.285) and 0.061 (SE 0.211), respectively. During pregnancy, five patients had an increase > or =15 mmHg across the site of repair at echocardiography, but only one patient required reintervention for recoarctation after delivery. Four of the 98 children (4%) had a congenital heart defect. CONCLUSION: Pregnancy is well tolerated in women after repair of aortic coarctation. However, an excess of miscarriages and hypertensive disorders of pregnancy were found. 相似文献
37.
38.
39.
Taes YE De Bacquer D De Backer G Delanghe JR 《The Journal of clinical endocrinology and metabolism》2005,90(1):594; author reply 594-594; author reply 595