全文获取类型
收费全文 | 2376850篇 |
免费 | 176433篇 |
国内免费 | 3394篇 |
专业分类
耳鼻咽喉 | 32407篇 |
儿科学 | 76841篇 |
妇产科学 | 63313篇 |
基础医学 | 351942篇 |
口腔科学 | 64531篇 |
临床医学 | 213477篇 |
内科学 | 464978篇 |
皮肤病学 | 52668篇 |
神经病学 | 187896篇 |
特种医学 | 88677篇 |
外国民族医学 | 489篇 |
外科学 | 358117篇 |
综合类 | 47655篇 |
现状与发展 | 12篇 |
一般理论 | 857篇 |
预防医学 | 185295篇 |
眼科学 | 55105篇 |
药学 | 176714篇 |
11篇 | |
中国医学 | 4686篇 |
肿瘤学 | 131006篇 |
出版年
2021年 | 19874篇 |
2019年 | 20400篇 |
2018年 | 28313篇 |
2017年 | 21069篇 |
2016年 | 23387篇 |
2015年 | 26405篇 |
2014年 | 37014篇 |
2013年 | 55313篇 |
2012年 | 77025篇 |
2011年 | 81878篇 |
2010年 | 48375篇 |
2009年 | 45687篇 |
2008年 | 76668篇 |
2007年 | 81597篇 |
2006年 | 82311篇 |
2005年 | 79645篇 |
2004年 | 76045篇 |
2003年 | 73234篇 |
2002年 | 70832篇 |
2001年 | 109208篇 |
2000年 | 112004篇 |
1999年 | 93876篇 |
1998年 | 27163篇 |
1997年 | 23776篇 |
1996年 | 24185篇 |
1995年 | 22819篇 |
1994年 | 20996篇 |
1993年 | 19794篇 |
1992年 | 72171篇 |
1991年 | 70205篇 |
1990年 | 68520篇 |
1989年 | 65768篇 |
1988年 | 60384篇 |
1987年 | 59205篇 |
1986年 | 55289篇 |
1985年 | 53071篇 |
1984年 | 39377篇 |
1983年 | 33446篇 |
1982年 | 19900篇 |
1979年 | 35899篇 |
1978年 | 25682篇 |
1977年 | 21262篇 |
1976年 | 20358篇 |
1975年 | 21833篇 |
1974年 | 26183篇 |
1973年 | 24850篇 |
1972年 | 23227篇 |
1971年 | 22065篇 |
1970年 | 20273篇 |
1969年 | 19348篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
131.
Weiyu Ye Anna Olsson-Brown Robert A. Watson Vincent T. F. Cheung Robert D. Morgan Isar Nassiri Rosalin Cooper Chelsea A. Taylor Umair Akbani Oliver Brain Rubeta N. Matin Nicholas Coupe Mark R. Middleton Mark Coles Joseph J. Sacco Miranda J. Payne Benjamin P. Fairfax 《British journal of cancer》2021,124(10):1661
Background Immune checkpoint blockers (ICBs) activate CD8+ T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters and clinical outcome is unclear.Methods Retrospective evaluation of irAEs on survival was performed across primary (N = 144) and secondary (N = 211) independent cohorts of patients with metastatic melanoma receiving single agent (pembrolizumab/nivolumab—sICB) or combination (nivolumab and ipilimumab—cICB) checkpoint blockade. RNA from pre-treatment and post-treatment CD8+ T cells was sequenced and differential gene expression according to irAE development assessed.Results 58.3% of patients developed early irAEs and this was associated with longer progression-free (PFS) and overall survival (OS) across both cohorts (log-rank test, OS: P < 0.0001). Median survival for patients without irAEs was 16.6 months (95% CI: 10.9–33.4) versus not-reached (P = 2.8 × 10−6). Pre-treatment monocyte and neutrophil counts, but not BMI, were additional predictors of clinical outcome. Differential expression of numerous gene pathway members was observed in CD8+ T cells according to irAE development, and patients not developing irAEs demonstrating upregulated CXCR1 pre- and post-treatment.Conclusions Early irAE development post-ICB is associated with favourable survival in MM. Development of irAEs is coupled to expression of numerous gene pathways, suggesting irAE development in-part reflects baseline immune activation.Subject terms: Immunotherapy, Melanoma 相似文献
132.
Qiaojie Wang Karan Goswami Noam Shohat Arash Aalirezaie Jorge Manrique Javad Parvizi 《The Journal of arthroplasty》2019,34(5):947-953
Background
Whether prolonged operative time is an independent risk factor for subsequent surgical site infection (SSI) and periprosthetic joint infection (PJI) following total joint arthroplasty (TJA) remains a clinically significant and underexplored issue. The aim of this study is to investigate the association between operative time and the risk of subsequent SSI and PJI in patients undergoing primary TJA.Methods
We retrospectively reviewed 17,342 primary unilateral total knee arthroplasty and total hip arthroplasty performed at a single institution between 2005 and 2016, with a minimum follow-up of 1 year. A multivariate logistic regression model was conducted to identify the association between operative time and the development of SSI within 90 days and PJI within 1 year.Results
Overall, the incidence of 90-day SSI and 1-year PJI was 1.2% and 0.8%, respectively. Patients with an operative time of >90 minutes had a significantly higher incidence of SSI and PJI (2.1% and 1.4%, respectively) compared to cases lasting between 60 and 90 minutes (1.1% and 0.7%), and those lasting ≤60 minutes (0.9% and 0.7%, P < .01). In the multivariate model, the risk for infection increased by an odds ratio of 1.346 (95% confidential interval 1.114-1.627) for 90-day SSI and 1.253 (95% confidential interval 1.060-1.481) for 1-year PJI for each 20-minute increase in operative time.Conclusion
In patients undergoing primary TJA, each 20-minute increase in operative time was associated with nearly a 25% increased risk of subsequent PJI. We advocate that surgeons pay close attention to this underappreciated risk factor while maintaining safe operative practices, which minimize unnecessary steps and wasted time in the operating room. 相似文献133.
134.
135.
136.
137.
138.
139.
140.