收费全文 | 1846篇 |
免费 | 100篇 |
国内免费 | 16篇 |
耳鼻咽喉 | 25篇 |
儿科学 | 63篇 |
妇产科学 | 82篇 |
基础医学 | 214篇 |
口腔科学 | 18篇 |
临床医学 | 199篇 |
内科学 | 265篇 |
皮肤病学 | 7篇 |
神经病学 | 347篇 |
特种医学 | 85篇 |
外科学 | 306篇 |
综合类 | 19篇 |
一般理论 | 1篇 |
预防医学 | 86篇 |
眼科学 | 50篇 |
药学 | 92篇 |
中国医学 | 5篇 |
肿瘤学 | 98篇 |
2024年 | 2篇 |
2023年 | 13篇 |
2022年 | 19篇 |
2021年 | 65篇 |
2020年 | 33篇 |
2019年 | 54篇 |
2018年 | 49篇 |
2017年 | 34篇 |
2016年 | 45篇 |
2015年 | 47篇 |
2014年 | 87篇 |
2013年 | 128篇 |
2012年 | 155篇 |
2011年 | 166篇 |
2010年 | 96篇 |
2009年 | 100篇 |
2008年 | 124篇 |
2007年 | 105篇 |
2006年 | 116篇 |
2005年 | 110篇 |
2004年 | 90篇 |
2003年 | 87篇 |
2002年 | 72篇 |
2001年 | 10篇 |
2000年 | 3篇 |
1999年 | 9篇 |
1998年 | 15篇 |
1997年 | 15篇 |
1996年 | 11篇 |
1995年 | 10篇 |
1994年 | 9篇 |
1993年 | 11篇 |
1992年 | 5篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1988年 | 3篇 |
1987年 | 7篇 |
1986年 | 2篇 |
1985年 | 7篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1974年 | 3篇 |
1971年 | 1篇 |
1964年 | 1篇 |
Background
The association of aspirin use and nonsteroid anti-inflammatory drug (NSAID) use with amyotrophic lateral sclerosis (ALS) risk is unclear. This study determined whether use of any individual compound is associated with ALS risk by conducting a total population-based case-control study in Taiwan.Methods
A total of 729 patients with newly diagnosed ALS who had a severely disabling disease certificate between January 1, 2002, and December 1, 2008, comprised the case group. These cases were compared with 7290 sex-, age-, residence-, and insurance premium-matched controls. Drug use by each Anatomical Therapeutic Chemical code was analyzed using conditional logistic regression models. False discovery rate (FDR)-adjusted P values were reported in order to avoid inflating false positives.Results
Of the 1336 compounds, only the 266 with use cases exceeding 30 in our database were included in the screening analysis. Without controlling for steroid use, the analysis failed to reveal any compound that was inversely associated with ALS risk according to FDR criteria. After controlling for steroid use, we found use of the following compounds to be associated with ALS risk: aspirin, diphenhydramine (one of the antihistamines), and mefenamic acid (one of the NSAIDs). A multivariate analysis revealed that aspirin was independently inversely associated with ALS risk after controlling for diphenhydramine, mefenamic acid, and steroid use. The inverse association between aspirin and ALS was present predominately in patients older than 55 years.Conclusions
The results of this study suggested that aspirin use might reduce the risk of ALS, and the benefit might be more prominent for older people.Key words: amyotrophic lateral sclerosis, aspirin, case-control study 相似文献Rhythmic (RG) and artistic gymnastics (AG) are very popular female sports. These two disciplines share some common points but, at the same time, they display some relevant differences in terms of physical and technical characteristics. The aim of this study was as follows: (1) to clarify how gymnastic training background over the years could lead to the development and motor learning of the motor skills and (2) to highlight differences of conditional skills achieved by RG and AG athletes.
MethodsFor these aims, 45 athletes were selected, belonging to three balanced groups: promotional (PG, n?=?15), RG (n?=?15), and AG (n?=?15). Participants were tested for joints mobility, balance, explosive strength, speed, and endurance tests.
ResultsStatistical analysis showed a good test–retest reliability of the measurements (ICC?>?0.870) and some significant differences between PG, RG, and AG. RG showed higher values in joint mobility tests (coxo-femoral mobility, 166.7?±?6.3°; sit and reach, 20.5?±?1.9 cm; and scapulo-humeral mobility, 45.5?±?4.4 cm) with respect to AG, while AG showed higher values in endurance (1626.7?±?7.4 m), balance (4.33?±?1.35 n/60 s), and explosive strength (164.1?±?11.6 cm) compared to RG (p?<?0.05).
ConclusionRG and AG seem to be effective in enhancing different and sport-specific physical fitness and conditioning. RG enables, indeed, to develop more joints mobility whereas AG improves more strength, balance, and endurance. However, given the small sample size employed, these results should be replicated by further studies utilizing larger samples.
相似文献