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991.
992.
Jaroslav Men?ík Li Hong He Michael V. Swain 《Journal of the Mechanical Behavior of Biomedical Materials》2009,2(4):318-325
Load response of viscoelastic–plastic materials depends on the load magnitude and history, and can be described by rheological models consisting of springs and dashpots. The parameters in these models can be obtained by instrumented indentation. Time-dependent properties are determined best from the time course of indenter displacement under constant load, but one must consider also the initial loading history. For characterization of instantaneous elastic and plastic response, fast loading and unloading are necessary. The paper summarizes the formulae for indentation into elastic–plastic and viscoelastic–plastic materials, and proposes a procedure for testing and data evaluation. Its application is illustrated on the indentation of human enamel. 相似文献
993.
994.
Miroslava Krzyzankova Silvia Chovanova Petr Chlapek Matej Radsetoulal Jakub Neradil Karel Zitterbart Jaroslav Sterba Renata Veselska 《Tumour biology》2014,35(8):7617-7627
The induced differentiation of tumor cells into mature phenotypes is a promising strategy in cancer therapy. In this study, the effects of combined treatment with all-trans retinoic acid (ATRA) and lipoxygenase/cyclooxygenase inhibitors were examined in two osteosarcoma cell lines, Saos-2 and OSA-01. Caffeic acid and celecoxib were used as inhibitors of 5-lipoxygenase and of cyclooxygenase-2, respectively. Changes in the cell proliferation, matrix mineralization, and occurrence of differentiation markers were evaluated in treated cell populations at intervals. The results confirmed the capability of caffeic acid to enhance the antiproliferative effect of ATRA in both cell lines. In contrast, celecoxib showed the same effect in Saos-2 cells only. Furthermore, the extension of matrix mineralization was observed after combined treatment with ATRA and celecoxib or caffeic acid. The increased expression of osteogenic differentiation markers was observed in both cell lines after the combined application of ATRA and inhibitors. The obtained results clearly demonstrate the capability of lipoxygenase/cyclooxygenase inhibitors to enhance the antiproliferative and differentiating effect of ATRA in osteosarcoma cells, although some of these effects are specific and depend on the biological features of the respective tumor or cell line. 相似文献
995.
Krystyna Kluz Ondřej Toman Jiří Pařenica Martin Poloczek Martin Tesák Jaroslav Boudný Jindřich Špinar Martin Fiala 《Cor et vasa》2013,55(5):e453-e456
We present a case of a young woman, who was examined for polymorphic complaints. Life-threatening complications during a standard treatment occurred, because of severe left ventricular dysfunction caused by an incessant atrial tachycardia and subsequent tachycardia induced cardiomyopathy. The only symptom reflecting the serious diagnosis was a mild dyspnoea on exertion. Because of patient's dissimulation, this symptom was uncovered late. Focal atrial tachycardia was successfully treated with catheter ablation and the treatment resulted in normalization of the left ventricular systolic function in three months. 相似文献
996.
Francesco Dal Dosso Tadej Kokalj Jaroslav Belotserkovsky Dragana Spasic Jeroen Lammertyn 《Biomedical microdevices》2018,20(2):44
In this work, we present a new iSIMPLE concept (infusion Self-powered Imbibing Microfluidic Pump by Liquid Encapsulation), which requires no external power for activation nor liquid manipulation, it is easy to use while its fabrication method is extremely simple, inexpensive and suited for mass replication. The pump consists of a working liquid, which is - after finger activation - absorbed in a porous material (e.g. filter paper). The air expelled from the porous material increases the pressure in the downstream outlet channel and propels the outlet liquid (i.e. the sample) through the channel or ejects it. Here we investigated the influence of different filter papers on the iSIMPLE flow rates, achieving a wide range from 30 down to 0.07 μL/min. We also demonstrated the versatility of the iSIMPLE in terms of the liquid volume that can be manipulated (from 0.5 μL up to 150 μL) and the working pressure reaching 64 kPa, unprecedented high for a self-powered microfluidics pump. In addition, using a 34 G microneedle mounted on the iSIMPLE, we successfully injected liquids with different viscosities (from 0.93 up to 55.88 cP) both into an agarose matrix and a skin-like biological ex vivo substrate (i.e. chicken breast tissue). This work validated the compatibility of the iSIMPLE with drug delivery in a controlled way into a skin-like matrix, envisioning a whole new scenario for intradermal injections using self-contained skin patch. In addition, due to the extreme flexibility of the design and manufacturing, the iSIMPLE concept offers enormous opportunities for completely autonomous, portable and cost effective LOC devices. 相似文献
997.
Marcela Kopáčová Ilja Tachecí Jaroslav Květina Jan Bureš Martin Kuneš Stanislav Špelda Věra Tyčová Zbyněk Svoboda Stanislav Rejchrt 《Digestive diseases and sciences》2010,55(3):626-630
The aim of this project was to develop a methodology to introduce wireless video capsule endoscopy in preclinical research.
Five mature female pigs (Sus scrofa domestica) were selected for the study. Capsule endoscopes (the EndoCapsule system; Olympus) were introduced into the duodenum endoscopically
in each of the animals. The life span of batteries (i.e., total time of endoscopy recording) was 487–540 min (median 492 min).
The capsule endoscope reached the cecum during enteroscopy once (after 7 h 57 min), in the remaining cases, endoscopy recordings
terminated in the distal or terminal ileum. All capsule enteroscopies found a normal pattern of the small intestine. The intestinal
lumen is narrower, transverse folds are sparse or even absent, villi are wider but less prominent in pigs compared to humans.
Capsule endoscopy in experimental pigs will be helpful for future trials on injury of different drugs and xenobiotics to the
small bowel. 相似文献
998.
Jaroslav Tumas Kotryna Kvederaviciute Marius Petrulionis Benediktas Kurlinkus Arnas Rimkus Greta Sakalauskaite Jonas Cicenas Audrius Sileikis 《Medical oncology (Northwood, London, England)》2016,33(12):133
Pancreatic cancer is one of the worst prognoses of all malignancies. More than 40,000 deaths a year from this disease are observed in European Union alone. The only possibly curative treatment of pancreatic cancer is surgery, yet only 15–20% of patients have operable disease and even patients, which go through surgery and adjuvant chemotherapy, survival is less than 30%. The sensitive and specific biomarkers which could be used for the advance of early diagnostics are needed and constantly researched. Metabolomics is a technology which analyzes the concentrations of low-molecular-weight metabolites (the metabolome) has lately effectively developed due to the improvements in analytical technology. Metabolome analysis can be a one of the useful approaches for the biomarker discovery and disease diagnosis. Here we discuss recent discoveries in the field of pancreatic cancer metabolomics as well as the most promising biomarkers for diagnostics, prognosis and prediction. 相似文献
999.
Kamil Zeleňák Du?an Mi?tuna Jaroslav Lú?an Hubert Polá?ek 《Cardiovascular and interventional radiology》2010,33(3):643-645
Esophageal stent fractures occur quite rarely. A 61-year-old male patient was previously treated for rupture of benign stenosis,
occurring after dilatation, by implanting an esophageal stent. However, a year after implantation, the patient suffered from
dysphagia caused by the broken esophageal stent. He was treated with the interventional radiology technique, whereby a second
implantation of the esophageal stent was carried out quite successfully. 相似文献
1000.