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991.
Acute epiphyseal osteomyelitis in children 总被引:1,自引:0,他引:1
Nine children over 20 months of age had acute osteomyelitis of the epiphysis of a long bone. The clinical features varied, but all of the patients had pain at the infected site and an elevated erythrocyte sedimentation rate. The distal femur was involved in seven cases, the proximal tibia in two, and the proximal humerus in one. In two patients there was a contiguous metaphyseal lesion, while the other seven patients (eight sites) had lesions limited to the epiphysis. Bone scintigraphy clearly identified the infected sites in all seven patients in whom it was performed, and allowed an early diagnosis in four cases. Radiographs showed a lytic lesion of the epiphysis that corresponded to the scintigraphic findings in all cases. The vascular supply to the epiphysis and the microscopic structure of the epiphyseal venous sinusoids provide locations that favor lodgement of blood-borne organisms. The epiphysis of the child should be recognized as another site of hematogenous osteomyelitis. 相似文献
992.
Shug AL; Shrago E; Bittar N; Folts JD; Koke JR 《The American journal of physiology》1975,228(3):689-692
993.
Macrofilaricides and onchocerciasis control, mathematical modelling of the prospects for elimination
William Soumbey Alley Gerrit J van Oortmarssen Boakye A Boatin Nico JD Nagelkerke Anton P Plaisier Jan HF Remme Janis Lazdins Gerard JJM Borsboom J Dik F Habbema 《BMC public health》2001,1(1):12-5
Background
In most endemic parts of the world, onchocerciasis (river blindness) control relies, or will soon rely, exclusively on mass treatment with the microfilaricide ivermectin. Worldwide eradication of the parasite by means of this drug is unlikely. Macrofilaricidal drugs are currently being developed for human use.Methods
We used ONCHOSIM, a microsimulation mathematical model of the dynamics of onchocerciasis transmission, to explore the potentials of a hypothetical macrofilaricidal drug for the elimination of onchocerciasis under different epidemiological conditions, as characterized by previous intervention strategies, vectorial capacity and levels of coverage.Results
With a high vector biting rate and poor coverage, a very effective macrofilaricide would appear to have a substantially higher potential for achieving elimination of the parasite than does ivermectin.Conclusions
Macrofilaricides have a substantially higher potential for achieving onchocerciasis elimination than ivermectin, but high coverage levels are still key. When these drugs become available, onchocerciasis elimination strategies should be reconsidered. In view of the impact of control efforts preceding the introduction of macrofilaricides on the success of elimination, it is important to sustain current control efforts. 相似文献994.
Bedwetting and behavioural and/or emotional problems 总被引:2,自引:0,他引:2
RA Hirasing FJM van Leerdam LB Bolk-Bennink JD Bosch 《Acta paediatrica (Oslo, Norway : 1992)》1997,86(10):1131-1134
Objective: To assess the link between enuresis nocturna and the severity of behavioural and/or emotional problems in Dutch children and the course of these problems. Setting: West-Mine Region in the Netherlands. Subjects and methods: Prospective cohort study involving 66 of the 80 bedwetting children from all 1652 children born in 1983 in this region. After 1 y, contact was still possible with 64 of the enuretics. We used the Dutch version of the Child Behaviour Checklist (CBCL) and a questionnaire about bedwetting. Results: The mean T-score for Total Problems (CBCL score) in 1992 (M1; mean age 8. 6) was 52. 1, and 1 y later was 49. 2 (M2). There was no significant difference in the CBCL scores for Ml, M2 and a matching group from the Dutch CBCL norm population, either in the group who remained wet or in the group who became dry. There were no differences between the sexes. There was no link between the severity of behavioural and emotional problems and the frequency of bedwetting. However, more children with bedwetting than expected were in the clinical range. Conclusion: There was no difference in behavioural and/or emotional problems between the first and the second measurement and the matching group from the CBCL norm group. There were no differences in behavioural and/or emotional problems between primary and secondary bedwetters, nor were there any consequences related to the frequency of bedwetting. 相似文献
995.
JR BOWEN FL GIBSON Gl LESLIE JD ARNOLD PJ MA DR STARTE 《Journal of paediatrics and child health》1996,32(1):25-30
Objective : To assess the relationship between the Griffiths Mental Development Scales at 1 and 3 years and the Stanford-Binet Intelligence Scale (S-B) and Beery Test of Visual-Motor Integration (VMI) at 5 years in extremely low birthweight (ELBW) children.
Methodology : Prospective study of 45 ELBW infants, without severe neurosensory impairment, cared for in a single Level III neonatal intensive care unit.
Results : At 5 years, 36 (80%) children were of average intelligence, 8 (18%) had borderline intelligence and one was mentally retarded. The Griffiths general quotient (GQ) at 1 year had a weak correlation with the S year IQ (corr. coeff. = 0.47), with only 17% of children with a GQ< — 1 s.d. at 1 year receiving an IQ< — 1s.d. at 5 years. In contrast, the Griffiths GQ at 3 years correlated strongly with 5 year IQ (corr. coeff. = 0.78). Among those children with a 3 year GQ< — 1s.d., 67% had a 5 year IQ< — 1 s.d. and all had a 5 year IQ<89. The 3 year hearing and speech subscale correlated strongly with the 5 year S-B verbal comprehension factor (corr. coeff = 0.753) and the 3 year combined eye/hand co-ordination/performance quotient had a moderate correlation with the S-B non-verbal reasoning factor (corr coeff = 0.597) and with the Beery VMI (corr coeff = 0.49).
Conclusions : The 3 year Griffiths GQ is a good predictor of 5 year S-B IQ in ELBW children and can be used to identify children who may benefit from intervention prior to school entry. 相似文献
Methodology : Prospective study of 45 ELBW infants, without severe neurosensory impairment, cared for in a single Level III neonatal intensive care unit.
Results : At 5 years, 36 (80%) children were of average intelligence, 8 (18%) had borderline intelligence and one was mentally retarded. The Griffiths general quotient (GQ) at 1 year had a weak correlation with the S year IQ (corr. coeff. = 0.47), with only 17% of children with a GQ< — 1 s.d. at 1 year receiving an IQ< — 1s.d. at 5 years. In contrast, the Griffiths GQ at 3 years correlated strongly with 5 year IQ (corr. coeff. = 0.78). Among those children with a 3 year GQ< — 1s.d., 67% had a 5 year IQ< — 1 s.d. and all had a 5 year IQ<89. The 3 year hearing and speech subscale correlated strongly with the 5 year S-B verbal comprehension factor (corr. coeff = 0.753) and the 3 year combined eye/hand co-ordination/performance quotient had a moderate correlation with the S-B non-verbal reasoning factor (corr coeff = 0.597) and with the Beery VMI (corr coeff = 0.49).
Conclusions : The 3 year Griffiths GQ is a good predictor of 5 year S-B IQ in ELBW children and can be used to identify children who may benefit from intervention prior to school entry. 相似文献
996.
FH Karachaliou K Karavanaki R Greenwood H Morgan JD Baum 《Archives of disease in childhood》1996,75(2):124-128
The progression of early measures of microvascular disease and autonomic neuropathy were studied in a group of 81 children with insulin dependent diabetes mellitus over a mean interval of 4.2 years. Repeated measurements were made of blood pressure, albumin excretion, joint mobility, and pupillary dilatation in darkness. Over the years between the first and the second study, systolic and diastolic blood pressure showed positive tracking correlations (r = 0.38 and r = 0.32) with a small but significant deviation from normality; albumin/creatinine ratio was significantly increased (0.79 v 0.55); a greater number of children were identified in the second study as having limitation of mobility of the fifth metacarpophalangeal joint; and pupillary dilatation in darkness significantly decreased (61.5% v 62.9%); 62% of the children with one or more abnormal measurements in the first study were found to have measurements outside the normal ranges in the second study, indicating a consistency in observations over time. It remains to be seen with what accuracy these measurements predict adult onset clinical disease. 相似文献
997.
Jenner MJ Micallef IN Rohatiner AZ Kelsey SM Newland AC Cavenagh JD 《Medical oncology (Northwood, London, England)》2000,17(4):333-336
A 36-year-old man underwent matched unrelated donor bone marrow transplantation for chronic myeloid leukaemia. He developed
severe hepatic veno-occlusive disease as an early post-transplant complication. Tissue plasminogen activator was initially
felt to be contraindicated since the patient had concomitant pericarditis. Defibrotide was therefore commenced as treatment
for veno-occlusive disease. The pericarditis improved but the veno-occlusive disease continued to worsen (peak bilirubin 353
μmol/I). Tissue plasminogen activator followed by a heparin infusion was therefore administered. However, he proceeded to
develop haemorrhagic cardiac tamponade that required drainage. Thrombolysis was therefore discontinued and treatment with
defibrotide resumed after an interval of 48 h. The veno-occlusive disease gradually resolved and defibrotide was discontinued
once the bilirubin had plateaued. He was discharged home on day +52 post-transplant. 相似文献
998.
Computerized radiologic reporting with voice data-entry 总被引:2,自引:0,他引:2
999.
1000.